Hydrodynamic Cavitation-based Rapid Expansion of Hesperidin-rich Products from Waste Citrus Peel as a Potential Tool Against COVID-19

Meneguzzo, Francesco; Ciriminna, Rosaria; Zabini, Federica; Pagliaro, Mario

doi:10.20944/preprints202004.0152.v1

Cited by 12 publications

(7 citation statements)

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“…A flavanone glycoside isolated from citrus fruits is Hesperidin, which has been reported to work against COVID-19. Hesperidin rich citrus peel from the waste were used in the study which underwent hydrodynamic cavitation-based speedy expansion and act as antiviral agent against COVID-19 ( Meneguzzo et al, 2020 ). Fig.…”

Section: Traditional Cure For Covid-19: a Possible Room For Ayurvedamentioning

confidence: 99%

Herbal immune-boosters: Substantial warriors of pandemic Covid-19 battle

et al. 2021

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Highlights Coronavirus pandemic has created a global alarming situation. SARS-CoV shares sequence homology with bats, therefore, considered as origin. Scientists are burning midnight's oil to discover drug or vaccine against this deleterious virus. Medicinal plants should be explored to find a cure for this disease. Phyto-constituents are ubiquitously synthesised in plants, effective against SARS-CoV-2. Clinical trials for herbal formulations are promoted to find drug or vaccine. Other armours like physical fitness, balanced diet are promoted for boosting immunity.

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Section: Traditional Cure For Covid-19: a Possible Room For Ayurvedamentioning

confidence: 99%

Herbal immune-boosters: Substantial warriors of pandemic Covid-19 battle

et al. 2021

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“…T cell contributes to COVID-19 hyperinflammation. T cells are the frontline defender to control viral infections and a dysregulated T cell immune response may lead to immunopathology and ultimately result in [193] Nafamostat Anti-viral Synthetic serine protease inhibitor that inhibits the fusion of membrane by decreasing Cathepsin B release [194]…”

Section: Relationship Between Viral Load Host Inflammation and Disementioning

confidence: 99%

Immune dysregulation and system pathology in COVID-19

et al. 2021

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The coronavirus disease 19 (COVID-19) caused by the novel coronavirus known as SARS-CoV-2 has caused a global public health crisis. As of 7 January 2021, 87,640,402 confirmed cases and 1,891,692 mortalities have been reported worldwide. Studies focusing on the epidemiological and clinical characteristics of COVID-19 patients have suggested a dysregulated immune response characterized by lymphopenia and cytokine storm in these patients. The exaggerated immune response induced by the cytokine storm causes septic shock, acute respiratory distress syndrome (ARDS), and/or multiple organs failure, which increases the fatality rate of patients with SARS-CoV-2 infection. Herein, we review the recent research progress on epidemiology, clinical features, and system pathology in COVID-19. Moreover, we summarized the recent therapeutic strategies, which are either approved, under clinical trial, and/or under investigation by the local or global health authorities. We assume that treatments should focus on the use of antiviral drugs in combination with immunomodulators as well as treatment of the underlying comorbidities.

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“…Hesperidin, naringin, and pectin from citrus peels have also proved their potency against COVID-19 through a recent computational and experimental study 85 .…”

Section: Recent Evidence Of Uses Of Herbs For Covid-19mentioning

confidence: 99%

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2021

IJPSR

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Coronavirus disease (COVID-19) has become pandemic in no time in the world. Understanding the pathophysiological similarities with previously known viruses of the class gave opportunities to explore various molecular targets against COVID-19. Vaccines unavailability propose different research approaches of treatment, including various previously known and some new synthetic molecules, which are also associated with many unwanted effects. Phytochemical compounds and formulations also gain interest in this era, and all the traditional medicine systems were analyzed for any probable therapeutic possibilities. Hence author summarize the various approaches of herbal-based medicine against COVID-19 infection. Ayurveda, Siddha, Unani, Homeopathy, and Chinese medicine systems constitute major traditional herbal-based systems known worldwide. Previous literature were studied to recapitulated findings with modern multi-mechanistic approaches and propose the use of herbals against COVID-19. Scientists are identifying all the possible interventions associated with herbal-based systems to have efficacy against various mechanisms against viral infection. Various herbal extracts and formulations are utilized to increase the human body's immune system to counter the pathophysiological changes due to COVID-19 infections. Promotion of these herbal-based medicines having a positive impact on the immune system is essential now. The review discussed the old and novel approaches revealing the efficacy of different phytoconstituents and herbal-based medicines against COVID-19. This review briefly highlighted the use of traditional herbal-based medicine systems against the novel coronavirus utilizing the modern approaches of multimechanistic targeting. A thorough investigation of different formulations from these systems is warranted through clinical studies for their global acceptance.

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Hydrodynamic Cavitation-based Rapid Expansion of Hesperidin-rich Products from Waste Citrus Peel as a Potential Tool Against COVID-19

Cited by 12 publications

References 58 publications

Herbal immune-boosters: Substantial warriors of pandemic Covid-19 battle

Herbal immune-boosters: Substantial warriors of pandemic Covid-19 battle

Immune dysregulation and system pathology in COVID-19

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