Hydrocortisone nanosuspensions for ophthalmic delivery: A comparative study between microfluidic nanoprecipitation and wet milling

Ali, Hany S.M.; York, Peter; Ali, Ahmed Mahmoud Abdelhaleem; Blagden, Nicholas

doi:10.1016/j.jconrel.2010.10.007

Cited by 214 publications

(117 citation statements)

References 35 publications

Supporting

Mentioning

111

Contrasting

Unclassified

Order By: Relevance

“…3 Compared with other nanoscale drug delivery systems, nanosuspensions show promise for enhancing dissolution and hence the bioavailability of poorly water-soluble drugs, by eliminating the effects of food, allowing for dose escalation, and improving efficacy and safety. [4][5][6] Since the 1990s, many commercial products, including Rapamune have been marketed successfully. 7 However, in spite of the advantages of nanosuspensions, there are many drawbacks associated with nanosuspension technology.…”

Section: Introductionmentioning

confidence: 99%

Formulating food protein-stabilized indomethacin nanosuspensions into pellets by fluid-bed coating technology: physical characterization, redispersibility, and dissolution

Lü²,

Qi³

et al. 2013

IJN

View full text Add to dashboard Cite

Background: Drug nanosuspensions are very promising for enhancing the dissolution and bioavailability of drugs that are poorly soluble in water. However, the poor stability of nanosuspensions, reflected in particle growth, aggregation/agglomeration, and change in crystallinity state greatly limits their applications. Solidification of nanosuspensions is an ideal strategy for addressing this problem. Hence, the present work aimed to convert drug nanosuspensions into pellets using fluid-bed coating technology. Methods: Indomethacin nanosuspensions were prepared by the precipitation-ultrasonication method using food proteins (soybean protein isolate, whey protein isolate, β-lactoglobulin) as stabilizers. Dried nanosuspensions were prepared by coating the nanosuspensions onto pellets. The redispersibility, drug dissolution, solid-state forms, and morphology of the dried nanosuspensions were evaluated. Results: The mean particle size for the nanosuspensions stabilized using soybean protein isolate, whey protein isolate, and β-lactoglobulin was 588 nm, 320 nm, and 243 nm, respectively. The nanosuspensions could be successfully layered onto pellets with high coating efficiency. Both the dried nanosuspensions and nanosuspensions in their original amorphous state and not influenced by the fluid-bed coating drying process could be redispersed in water, maintaining their original particle size and size distribution. Both the dried nanosuspensions and the original drug nanosuspensions showed similar dissolution profiles, which were both much faster than that of the raw crystals. Conclusion: Fluid-bed coating technology has potential for use in the solidification of drug nanosuspensions.

show abstract

Section: Introductionmentioning

confidence: 99%

Formulating food protein-stabilized indomethacin nanosuspensions into pellets by fluid-bed coating technology: physical characterization, redispersibility, and dissolution

Lü²,

Qi³

et al. 2013

IJN

View full text Add to dashboard Cite

show abstract

“…PdI is an indication of size distribution of the NS population and should be in the range of 0-0.2 to ensure the uniformity and homogeneity of drug delivery system. 36 It was found that the particle size of NS prepared without the addition of any stabilizer was 6 µm as a consequence of particle aggregation. Conversely, as shown in Table 1, the studied stabilizers at their optimum concentrations were able to achieve nano-sized particles.…”

mentioning

confidence: 99%

The relevancy of controlled nanocrystallization on rifampicin characteristics and cytotoxicity

Mohyeldin

Mehanna

Elgindy

2016

IJN

View full text Add to dashboard Cite

Purpose This article investigated the influence of novel rifampicin nanosuspension (RIF NS) for enhancing drug delivery properties. Methods RIF NS was fabricated using the antisolvent precipitation technique. The impact of solvent type and flow rate, stabilizer type and concentration, and stirring time and apparatus together with the solvent–antisolvent volume ratio on its controlled nanocrystallization has been evaluated. NSs were characterized by transmission electron microscopy, particle size and zeta potential analysis, solubility, and dissolution profiles. The compatibility between RIF and the stabilizer was investigated via Fourier transform infrared spectroscopy and the differential scanning calorimetry techniques. The shelf-life stability of the RIF NS was assessed within a period of 3 months at different storage temperatures. Cell cytotoxicity was evaluated using 3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay on lung epithelial cells. Results Polyvinyl alcohol at 0.4% w/v, 1:15 methanol to deionized water volume ratio and 30-minutes sonication were the optimal parameters for RIF NS preparation. Nanocrystals were obtained with a nanometeric particle size (101 nm) and a negative zeta potential (−26 mV). NS exhibited a 50-fold enhancement in RIF solubility and 97% of RIF was dissolved after 10 minutes. The RIF NS was stable at 4±0.5°C with no significant change in particle size or zeta potential. The MTT cytotoxicity assay of RIF NS demonstrated a good safety profile and reduction in cell cytotoxicity with half maximal inhibitory concentration values of 0.5 and 0.8 mg/mL for free RIF and RIF NS, respectively. Conclusion A novel RIF NS could be followed as an approach for enhancing RIF physicochemical characteristics with a prominence of a safer and better drug delivery.

show abstract

“…For example, Kassem et al (2007) found that the corticosteroid coated by nanosuspensions have better solubility than different kinds of corticosteroid solution, which lead to a more remarkable effect. In another study, Ali et al (2011) prepared the hydrocortisone nanosuspension by precipitation and grind. They chose the hydrocortisone solution as the control group.…”

Section: Nanosuspensionsmentioning

confidence: 99%

Advance of the application of nano-controlled release system in ophthalmic drug delivery

Wang

Zhang

2015

Drug Delivery

View full text Add to dashboard Cite

Hydrocortisone nanosuspensions for ophthalmic delivery: A comparative study between microfluidic nanoprecipitation and wet milling

Cited by 214 publications

References 35 publications

Formulating food protein-stabilized indomethacin nanosuspensions into pellets by fluid-bed coating technology: physical characterization, redispersibility, and dissolution

Formulating food protein-stabilized indomethacin nanosuspensions into pellets by fluid-bed coating technology: physical characterization, redispersibility, and dissolution

The relevancy of controlled nanocrystallization on rifampicin characteristics and cytotoxicity

Advance of the application of nano-controlled release system in ophthalmic drug delivery

Contact Info

Product

Resources

About