Hydrocortisone abolishes the angiotensin II-mediated potentiation of endothelin-1 in bovine bronchi

Brown, Anthony R.; Nally, Jane E.

doi:10.1042/cs20000163

Cited by 5 publications

(5 citation statements)

References 19 publications

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“…That study found that this cytokine response was mediated by AngII and was inhibited by losartan, an AT 1 receptor antagonist. This supports a role for AngII in inducing bronchial constriction via the AT 1 receptor [32]. This supports a role for AngII in inducing bronchial constriction via the AT 1 receptor [32].…”

Section: Ras and Copdsupporting

confidence: 77%

Renin–angiotensin system blockade: a novel therapeutic approach in chronic obstructive pulmonary disease

et al. 2012

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ACE (angiotensin-converting enzyme) inhibitors and ARBs (angiotensin II receptor blockers) are already widely used for the treatment and prevention of cardiovascular disease and their potential role in other disease states has become increasingly recognized. COPD (chronic obstructive pulmonary disease) is characterized by pathological inflammatory processes involving the lung parenchyma, airways and vascular bed. The aim of the present review is to outline the role of the RAS (renin-angiotensin system) in the pathogenesis of COPD, including reference to results from fibrotic lung conditions and pulmonary hypertension. The review will, in particular, address the emerging evidence that ACE inhibition could have a beneficial effect on skeletal muscle function and cardiovascular co-morbidity in COPD patients. The evidence to support the effect of RAS blockade as a novel therapeutic approach in COPD will be discussed.

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Section: Ras and Copdsupporting

confidence: 77%

Renin–angiotensin system blockade: a novel therapeutic approach in chronic obstructive pulmonary disease

et al. 2012

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“…Although AngII can act as a weak bronchoconstrictor through its AT 1 R, it can act synergistically with endothelin-1 (ET-1) to evoke more powerful contractions in bronchial bovine smooth muscles [103,104]. This mechanism might be mediated indirectly by leukotrienes [105].…”

Section: Angii Bronchial Hyperresponsiveness and Airway Remodelingmentioning

confidence: 98%

Local Renin-Angiotensin II Systems, Angiotensin-Converting Enzyme and its Homologue ACE2: Their Potential Role in the Pathogenesis of Chronic Obstructive Pulmonary Diseases, Pulmonary Hypertension and Acute Respiratory Distress Syndrome

Kaparianos¹,

Argyropoulou²

2011

CMC

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Renin-angiotensin II-aldosterone axis has long been known as a regulator of blood pressure and fluid homeostasis. Yet, local renin-angiotensin II systems have been discovered and novel actions of angiotensin II (AngII) have emerged among which its ability to act as a immunomodulator and profibrotic molecule. The enzyme responsible for its synthesis, Angiotensin-converting-enzyme (ACE), is present in high concentrations in lung tissue. In the present paper, we review data from studies of the past decade that implicate AngII and functional polymorphisms of the ACE gene that increase ACE activity with increased susceptibility for asthma and chronic obstructive pulmonary disease (COPD) and for pulmonary hypertension. Moreover, drugs that inhibit the synthesis of AngII (ACE inhibitors) or that antagonize its actions on its receptors (Angiotensin II receptor blockers -ARBs) have been shown to provide beneficial effects. Another recent discovery reviewed is the presence of a homologue of ACE, ACE2, which cleaves a single amino acid from AngII and forms a heptapeptide with vasodilatory actions, Ang 1-7. The balance between ACE and ACE2 is crucial for controlling AngII levels. ACE and ACE2 also appear to modify the severity of Acute Respiratory Distress Syndrome (ARDS), with ACE2 playing a protective role. Finally, mention is made to the recent discovery of ACE2 as a receptor for the SARS Corona Virus.

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“…The present study confirms that repeated sensitization results in pulmonary tissue injury including proliferation of smooth muscle cells in the trachea and alveoli, as evidenced by the stained tissue sections and morphometric measurements. Although AngII can act as a weak bronchoconstrictor throughits AT1R, it can act synergistically with endothelin-1 to produce more powerful contractions in bronchial bovine smooth muscles [19,20]. AngII can activate phospholipase A2 and the release of arachidonic acid from membrane phospholipids [21].…”

Section: Discussionmentioning

confidence: 99%

Effects of Valsartan and Telmisartan on the LungTissue Histology in Sensitized Rats

Algaem¹,

Numan²,

Hussain³

2013

AJPS

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The renin-angiotensin system (RAS)was potentially implicated in the pathogenesis of pulmonary disorders through its involvement in inducing pro-inflammatory mediators in the lung tissues. The present study evaluates the effects of the angiotensin receptor blockers (ARBs), telmisartan and valsartan, on the histological changes of lung tissues in sensitized rats. Twenty-fourWister female rats were randomly divided into four groups: A, negative control; B, valsartan-treated group; C, telmisartan-treated group and D, positive control. The rats in the groups B-D were sensitized and challenged with ovalbumin (OVA). Group A rats were sensitized and challenged with normal saline. Rats from groups B and C were treated with either valsartan or telmisartan (5mg/kg/day), respectively. The effects of administered ARBs on lung tissue structures were histologically evaluated. Treatment with telmisartan significantly attenuates the inflammatory and the hyper-proliferative changes in lung tissue after OVA-challenge, while valsartan did not show such effect. In conclusion, telmisartan demonstrates anti-inflammatory and anti-proliferative activities in sensitized rats, while valsartan lacks these effects.

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Hydrocortisone abolishes the angiotensin II-mediated potentiation of endothelin-1 in bovine bronchi

Cited by 5 publications

References 19 publications

Renin–angiotensin system blockade: a novel therapeutic approach in chronic obstructive pulmonary disease

Renin–angiotensin system blockade: a novel therapeutic approach in chronic obstructive pulmonary disease

Local Renin-Angiotensin II Systems, Angiotensin-Converting Enzyme and its Homologue ACE2: Their Potential Role in the Pathogenesis of Chronic Obstructive Pulmonary Diseases, Pulmonary Hypertension and Acute Respiratory Distress Syndrome

Effects of Valsartan and Telmisartan on the LungTissue Histology in Sensitized Rats

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