Abstract:Hydrocodone is a narcotic that is widely used, often in nursing mothers. Although case reports suggest that hydrocodone in breast milk sometimes may be problematic for the breastfed infant, no reports exist on the amount of its excretion into breast milk. Two mothers who were taking an acetaminophen and hydrocodone combination product donated pumped milk for analysis of hydrocodone. Their infants received an estimated 3.1% and 3.7% of the maternal weight-adjusted dosage, but the absolute hydrocodone dosages we… Show more
“…73 Case reports have suggested poor infant feeding, apnea, or lethargy which resolved with discontinuation of opioids in lactating mothers. 74,75 In particular, the possibility of genetic polymorphisms associated with impaired codeine metabolism in both mother and infant poses a danger of higher than anticipated RID, resulting in a practice of avoiding codeine in lactating individuals in lieu of short courses of oxycodone, hydrocodone, and nonopioid options including acetaminophen and NSAIDs. 76 Obstetric providers play an essential role in advocating for initiation and continuation of breastfeeding, and can assist their nonobstetric colleagues in determination of the safest alternative therapy.…”
In modern obstetric practice, providers will encounter patients for whom opioid use in pregnancy is reasonable or even necessary. A “one-size-fits-all” approach to the counseling and management of such patients is misguided. Understanding indications for ongoing opioid use in pregnancy is essential to patient-centered care. Specifically, recognition of the nuanced differences between opioid dependence and opioid use disorder is crucial for appropriate diagnosis, screening for common concurrent conditions, adequately counseling about individualized maternal and perinatal risks, and accurate documentation of diagnoses and medical decision-making. In this paper, we explore the current typical scenarios in which opioid use in pregnancy may be encountered, ongoing opioid prescribing should be considered, and provide a guide for the obstetric provider to navigate the antepartum, intrapartum, and postpartum periods.
Key Points
“…73 Case reports have suggested poor infant feeding, apnea, or lethargy which resolved with discontinuation of opioids in lactating mothers. 74,75 In particular, the possibility of genetic polymorphisms associated with impaired codeine metabolism in both mother and infant poses a danger of higher than anticipated RID, resulting in a practice of avoiding codeine in lactating individuals in lieu of short courses of oxycodone, hydrocodone, and nonopioid options including acetaminophen and NSAIDs. 76 Obstetric providers play an essential role in advocating for initiation and continuation of breastfeeding, and can assist their nonobstetric colleagues in determination of the safest alternative therapy.…”
In modern obstetric practice, providers will encounter patients for whom opioid use in pregnancy is reasonable or even necessary. A “one-size-fits-all” approach to the counseling and management of such patients is misguided. Understanding indications for ongoing opioid use in pregnancy is essential to patient-centered care. Specifically, recognition of the nuanced differences between opioid dependence and opioid use disorder is crucial for appropriate diagnosis, screening for common concurrent conditions, adequately counseling about individualized maternal and perinatal risks, and accurate documentation of diagnoses and medical decision-making. In this paper, we explore the current typical scenarios in which opioid use in pregnancy may be encountered, ongoing opioid prescribing should be considered, and provide a guide for the obstetric provider to navigate the antepartum, intrapartum, and postpartum periods.
Key Points
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