Hydrochlorothiazide vs Venlafaxine: Drug-induced Bullous Pemphigoid

Abstract

Pemphigoid group of dermatologic conditions is a group of autoimmune skin disorders resulting in blistering skin conditions. The two diseases that fall under this category are bullous pemphigoid and pemphigus vulgaris. While there are many similarities in these two disorders, there are numerous pathologic and biochemical differences which help us differentiate between these disorders. In this case report, we report a usual manifestation of bullous pemphigoid in a 72-year-old female secondary to use of a well-known antihypertensive (hydrochlorothiazide) and/or venlafaxine (anti-depressant).

Bullous pemphigoid secondary to pembrolizumab mimicking toxic epidermal necrolysis

“…4,5 Although around 50 medications have been implicated in drug-induced BP, 14 less is known about the delay of symptom onset from initiation of the culprit medication; reports have ranged from 6 weeks to several years. 15 Similar to other cases of BP secondary to pembrolizumab, our patient was successfully treated with systemic steroids. Because of the unpredictable timeline of the development of BP secondary to pembrolizumab, it is important to monitor for cutaneous symptoms while a patient is receiving the drug.…”