Hydrocephalus Secondary to Intradural Extramedullary Malignant Melanoma of Spinal Cord

Hironaka, Kohei; Tateyama, Kojiro; Tsukiyama, Atsushi; Adachi, Koji; Morita, Akio

doi:10.1016/j.wneu.2019.07.046

Cited by 7 publications

(4 citation statements)

References 18 publications

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“…The patient might have undergone a spinal tumorectomy directly without a VP shunt if spinal MRI had been performed in time. Melanocytic tumors can lead to metastasis via the shunt tube, and peritoneal dissemination has been reported previously [16]. In this patient, fortunately, the last CT scan did not show evidence of tumor metastasis.…”

Section: Discussionsupporting

confidence: 70%

“…In addition to pathological confirmation of malignant melanoma, we established the final diagnosis, as no evidence of primary melanocytic tumor outside the CNS was found [15]. Furthermore, there is no standard treatment for CNS malignant melanoma, whereas complete surgical excision might be a better approach, since these types of tumors are highly aggressive and radioresistant [16].…”

Section: Discussion and Con Clus Ionsmentioning

confidence: 99%

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Orthostatic tremor secondary to primary malignant melanoma of the spinal cord: A case report

Song

et al. 2022

Euro J of Neurology

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Background and purpose Orthostatic tremor and spinal cord melanoma are rare entities and seem unlikely to be associated. Herein, we report a patient diagnosed with orthostatic tremor secondary to primary malignant melanoma of the spinal cord. Case Presentation We report the case of a 67‐year‐old man who experienced tremor when he was standing, which disappeared when he was sitting or walking. He also reported gait disturbance and cognitive dysfunction. Electromyography revealed a regular and symmetric high‐frequency tremor in the lower extremities. The patient was admitted to a hospital several times and was diagnosed with primary orthostatic tremor and later hydrocephalus; thus, he received a ventriculoperitoneal shunt. Finally, he showed symptoms of the presence of melanoma in the spinal cord, which was supported by spinal cord magnetic resonance imaging findings. Primary malignant melanoma of the spinal cord was confirmed postoperatively. Conclusions Orthostatic tremor is a rare entity that can be characterized by specific high‐frequency tremors when the subject is standing. Considering that it remains unknown why this condition appears, some possible associations, such as primary spinal cord melanoma, should be considered. Thus, a comprehensive assessment of these types of patients is required. Our case report may facilitate the understanding of the pathophysiology and clinical symptoms of this disease.

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Section: Discussionsupporting

confidence: 70%

Section: Discussion and Con Clus Ionsmentioning

confidence: 99%

Orthostatic tremor secondary to primary malignant melanoma of the spinal cord: A case report

Song

et al. 2022

Euro J of Neurology

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“…In pediatrics, many of these cases are medulloblastoma, high-grade embryonal or glial tumors [18]. In the case of meningeal melanocytic neoplasms, Hironaka et al [19] reported that all prior cases (n = 6) of CNS melanoma with VP shunts resulted in peritoneal metastases. Our patient had a VP shunt due to a history of post-hemorrhagic hydrocephalus related to his prematurity, but, ultimately, it led to tumor dissemination.…”

Section: Discussionmentioning

confidence: 99%

Primary Diffuse Leptomeningeal Melanomatosis in a Child with Extracranial Metastasis: Case Report

Shahab,

Patil,

Fangusaro

et al. 2024

Current Oncology

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Primary meningeal melanomatosis is an extremely rare tumor with very few documented responses to treatment. A 3-year-old male with a complex past medical history, including prematurity and shunted hydrocephalus, was diagnosed with primary meningeal melanomatosis with peritoneal implants. Molecular testing revealed an NRAS Q61R mutation. The patient received proton craniospinal radiation followed by immunotherapy with nivolumab (1 mg/kg) and ipilimumab (3 mg/kg) IV every 3 weeks and, upon progression, he was switched to a higher dose of nivolumab (3 mg/kg IV every 2 weeks) and binimetinib (24 mg/m2/dose, twice a day). The patient had significant improvement of CNS disease with radiation therapy and initial immunotherapy but progression of extracranial metastatic peritoneal and abdominal disease. Radiation was not administered to the whole abdomen. After two cycles of nivolumab and treatment with the MEK inhibitor binimetinib, he had radiographic and clinical improvement in abdominal metastasis and ascitis. He ultimately died from RSV infection, Klebsiella sepsis, and subdural hemorrhage without evidence of tumor progression. This is the first report of a child with primary meningeal melanomatosis with extracranial metastatic disease with response to a combination of radiation, immunotherapy and MEK inhibitor therapy.

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“…The management of communicating hydrocephalus in cases of leptomeningeal metastasis can be challenging due to the high rate of complications. A case series reviewed ventriculoperitoneal shunting in patients with CNS melanoma and found that all of the patients developed peritoneal metastasis [ 13 ]. CSF shunting surgery resulted in rapid improvement in the mental status of 90.3% of patients in a study that was done on 31 patients [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Leptomeningeal Disease and Hydrocephalus as the First Presentation of Melanoma

Sawalha,

Alkilani

2023

Cureus

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We present a case of an 83-year-old man who developed acute hydrocephalus as the first presentation of leptomeningeal disease secondary to melanoma of unknown primary, which is an exceedingly rare subtype of melanoma, in addition to a very rare complication of malignancy in general, which was diagnosed with imaging as well as cytology modalities. This presentation is rare and highlights the importance of recognizing this condition.

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Hydrocephalus Secondary to Intradural Extramedullary Malignant Melanoma of Spinal Cord

Cited by 7 publications

References 18 publications

Orthostatic tremor secondary to primary malignant melanoma of the spinal cord: A case report

Orthostatic tremor secondary to primary malignant melanoma of the spinal cord: A case report

Primary Diffuse Leptomeningeal Melanomatosis in a Child with Extracranial Metastasis: Case Report

Leptomeningeal Disease and Hydrocephalus as the First Presentation of Melanoma

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