Hydrocephalus due to cerebrospinal fluid overproduction by bilateral choroid plexus papillomas

Abstract

CSF overproduction caused by bilateral choroid plexus papillomas can result in hydrocephalus. Radical resection of the bilateral ventricular lesions should be considered for this entity. Thorough evaluation of the surgical specimen is recommended because histological examination of only the lobular surface of the choroid plexus lesion may fail to identify choroid plexus neoplasm.

Hydrocephalus Due to Diffuse Villous Hyperplasia of the Choroid Plexus -Case Report-

“…1,3,5,7,10,13,16,18,19,21,22) However, pathological examination suggested DVHCP on the tissue surface but CPP in the lobular lesion, confounding the pathological diagnosis of DVHCP in one case. 11) Tl SPECT observed symmetric, marked uptake in the bilateral choroid plexuses on both early and delayed images and good washout, showing a negative retention index in our patient (Fig. 4).…”

“…Bilateral CPP is characterized by asymmetric enlarged choroid plexuses 9,15) which tend to be separated into lobules, 9,11) and cyst formation in a few cases. 15) However, the enlarged choroid plexuses were symmetric and resembled DVHCP on imaging in some cases, 12) enabling diagnosis only after pathological examination.…”

“…3) However, pathological findings may be needed to establish the diagnosis. 9,11) Initial VA shunt was subsequently followed by tissue resection and pathological examination due to the development of complications such as thrombosis and infection, resulting in the diagnosis of bilateral CPP. 11,15) In most previous patients, the diagnosis of DVHCP was established based on the histological findings.…”

“…9,11) Initial VA shunt was subsequently followed by tissue resection and pathological examination due to the development of complications such as thrombosis and infection, resulting in the diagnosis of bilateral CPP. 11,15) In most previous patients, the diagnosis of DVHCP was established based on the histological findings. 1,3,5,7,10,13,16,18,19,21,22) However, pathological examination suggested DVHCP on the tissue surface but CPP in the lobular lesion, confounding the pathological diagnosis of DVHCP in one case.…”

Cerebrospinal fluid hypersecretion in pediatric hydrocephalus

“…3,4,14,18,20,27,38,40,46,55,56,90,96,102,117,123,127 After surgical intervention (e.g., CPC or tumor removal), the rates of CSF production decreased, 4,20,35,46,51,90,96,117 and in some cases, there was no further need for a shunt. 27,51,56 In addition to CPP and CPH, overproduction of CSF contributing to hydrocephalus has also been implicated in idiopathic intracranial hypertension, 59 infectious hydrocephalus, 16 and intraventricular hemorrhage-associated hydrocephalus, 126 but secretion rates in the patients with these conditions have not been well documented.…”