Hydroalcoholic gel with Argentine propolis: the potential for antimicrobial and antioxidant activities, stability evaluation, and <i>in vitro</i> phenolic release

Salas, Augusto; Uriburu, Florencia María Correa; Zampini, Iris Catiana; Arias, Myriam; Moreno, María Inés Nieva; Deiú, Antonella Santillán; Bravo, Walter Roberto; Maldonado, Luis; Salomón, Virginia; Isla, Marı́a Inés

doi:10.1080/00218839.2020.1790791

Cited by 2 publications

(1 citation statement)

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“…2, while the color change was less remarked in formulation F4, that might be explained by its content of vitamin E as an additive antioxidant Table 1. Color change in F1 and F2 could be attributed to the negative effect of high temperature in addition to the presence of aqueous medium in these formulations, that induce the oxidation of phenolic groups into colored quinones compounds 20,21 . No change was observed in the consistency of the prepared formulations during the stability period.…”

Section: Characteristics Of Formulations During Accelerated Stability...mentioning

confidence: 99%

Microbiological and Analytical Evaluation of Semi-Solid Formulations of Doxycycline Hyclate under Accelerated Stability Conditionsand analytical evaluation of semi-solid formulations of Doxycycline Hyclate under accelerated stability conditions

Aasi,

Alahmad,

Beesh

et al. 2024

Baghdad Sci.J

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Doxycycline Hyclate (DOX) is a broad-spectrum antibiotic that belongs to the tetracycline family. It has been widely used in the treatment of several inflammatory diseases, and is considered the first-line therapy in the management of moderate to severe cases of acne. In this research, Doxycycline was formulated in four semi-solid formulations (F1and F2 as Gels, F3 and F4 as ointments), then these formulations were subjected to accelerated stability conditions for three months. The formulations were evaluated using microbiological and analytical methods after one and three months. Agar well diffusion method was used as a microbiological method to screen the antibacterial activity of semi-solid formulations against two types of bacteria, Staphylococcus Aureus and Pseudomonas Aeruginosa. HPLC was used as an analytical method for the quantitative and qualitative determination of these formulations. A comparison between a microbiological assay and analytical assay was achieved to evaluate the activity. The results showed that the ointment formulations were more stable than gel formulations since the percentages of drug were 91%, 93% at 25 ˚C after one month for formulations (F3, F4) against 90%,65% for formulations (F1, F2) respectively. Antibacterial activity results showed that formulation F4 had the highest zone of inhibition, which is 31mm for S.aurues and 26 mm for P. aeruginosa after storing it for three months at 25C°. The formulations were still effective despite the chemical degradation of doxycycline, this effectiveness returns to the fact that degradation products could still have active structural parts responsible for the antibacterial activity.

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Section: Characteristics Of Formulations During Accelerated Stability...mentioning

confidence: 99%