Hydroalcoholic extract based-ointment from Punica granatum L. peels with enhanced in vivo healing potential on dermal wounds

Hayouni, El Akrem; Miled, Khaled; Boubaker, Samir; Bellasfar, Zakaria; Abedrabba, Manaf; Iwaski, H.; Oku, Hirosuke; Mizutani, Takashi; Limam, Férid; Hamdi, Moktar

doi:10.1016/j.phymed.2011.02.011

Cited by 133 publications

(105 citation statements)

References 29 publications

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“…Taking this into account, the present study was conducted to assess the antifungal potential of medicinal plants, particularly to target the dandruff-causing yeast M. furfur. The present findings [24][25][26] However, the studied extracts had relatively high MIC and MYC values and thus cannot be considered a good antifungal agent.…”

Section: Discussionmentioning

confidence: 70%

Insignificant antifungal activity of plant extracts on Malassezia furfur

Lalitha¹,

Ramachandrappa²,

Krishnamurthy³

et al. 2016

J Pharm Negative Results

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Section: Discussionmentioning

confidence: 70%

Insignificant antifungal activity of plant extracts on Malassezia furfur

Lalitha¹,

Ramachandrappa²,

Krishnamurthy³

et al. 2016

J Pharm Negative Results

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“…Several in vitro studies, performed with extracts obtained from different parts of the P. granatum, proved their antifungal activity 9,[23][24][25][26] . However, only one clinic study with humans 12 verified the therapeutic potential of the gel Punica granatum at 10%.…”

Section: Discussionmentioning

confidence: 99%

Punica granatum Linn. prevention of oral candidiasis in patients undergoing anticancer treatment

Santos

Nóbrega²,

Arnaud

et al. 2017

Rev. odontol. UNESP

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Punica granatum ResumoIntrodução: A candidíase oral é considerada uma das complicações da terapia antineoplásica de cabeça e pescoço. Estudos revelam que a fitoterapia vem se mostrando uma alternativa promissora para o tratamento da candidíase. Objetivo: Avaliar a efetividade do gel de Punica granatum Linn. na prevenção da candidíase oral, em pacientes submetidos à radioterapia associada ou não a quimioterapia para tratamento de carcinoma de células escamosas na região de cabeça e pescoço, e efeitos adversos associados ao seu uso. Material e método: Foi realizado um ensaio clínico, duplo cego, no período de 2012 a 2013, com pacientes atendidos em um Hospital de referência para tratamento oncológico. A amostra foi composta por 17 pacientes que não apresentavam os sinais e sintomas de candidíase oral, os quais foram divididos em dois grupos: experimental (n=11): composto por pacientes que utilizaram o gel de Punica granatum Linn. 6,25%, desde o inicio do tratamento antineoplásico e concluído uma semana após o término do esquema terapêutico; controle (n=6): por pacientes que utilizaram o gel de Miconazol 2%, seguindo as mesmas orientações do grupo anterior. Os dados foram tabulados e analisados por meio da estatística descritiva e usado os testes Qui-quadrado e Cálculo da Correção Continuada de Yates (p<0,05). Resultado: Não se observou a candidíase oral em 63,6% dos pacientes do grupo experimental, e em nenhum paciente do grupo controle. Conclusão: A maioria dos pacientes que fizeram uso do gel experimental não apresentaram os sinais clínicos da infecção fúngica, e não houve a associação de efeitos adversos.Descritores: Punica granatum; fitoterapia; radioterapia; Candida albicans. AbstractIntroduction: Oral candidiasis is considered one of the complications of antineoplastic therapy of head and neck. Studies show that herbal medicine has proven to be a promising alternative for the treatment of candidiasis. Objective: To evaluate the effectiveness of the gel Punica granatum Linn. in the prevention of oral candidiasis in patients undergoing radiotherapy with or without chemotherapy for squamous cell carcinoma of the head and neck, and adverse effects associated with its use. Material and method: It was performed a clinical trial, double blind, in the period 2012-2013, with patients seen at a referral hospital for cancer treatment. The sample consisted of 17 patients who did not have signs nor symptoms of oral candidiasis. These patients were divided into two groups: experimental (n=11): composed of patients who used the gel Punica granatum Linn. 6.25% since the beginning of the anticancer treatment and completed a week after the end of the treatment regimen; control (n=6): for patients who used the gel Miconazol 2%, following the same guidelines of the previous group. Data were tabulated and analyzed using descriptive statistics, the chi-square test and calculation of continuing Yates correction (p<0.05). Result: There was no oral candidiasis in 63.6% of patients in the experimental group and in none of the control...

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“…Pomegranate peels are rich in tannins [34][35][36]. They have been used traditionally for their medicinal properties as anticancer, anti-inflammatory, antioxidant and antithelminthic [37,38] and for other purposes such as tanning, dyeing [39,40] and heavy metal removal [41]. Pomegranate peels are characterized by an interior network of membranes comprising almost 26-30% of total fruit weight and are characterized by substantial amounts of phenolic compounds, including flavonoids (anthocyanins, catechins and other complex flavonoids) and hydrolysable tannins (punicalin, pedunculagin, punicalagin, gallic and ellagic acid) [42][43][44].…”

Section: Pomegranatementioning

confidence: 99%