1988
DOI: 10.1016/0891-5849(88)90106-2
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Hydrixyl radical generation by the tetracycline antibiotics with free radical damage to DNA, lipids and carbohydrate in the presence of iron and copper salts

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Cited by 46 publications
(20 citation statements)
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“…A significant normalization of the level of the marker enzymes during LUT treatment may be beneficial, as indicated by the protective role of the drug. Increased free radical production stimulates LPO and is the source of the degradation of DNA, lipids and carbohydrates (23). Numerous flavonoid aglycones have been shown to have chain-breaking antioxidant properties and to quench free radicals, thereby exerting protective effects on macromolecules (24).…”
Section: Discussionmentioning
confidence: 99%
“…A significant normalization of the level of the marker enzymes during LUT treatment may be beneficial, as indicated by the protective role of the drug. Increased free radical production stimulates LPO and is the source of the degradation of DNA, lipids and carbohydrates (23). Numerous flavonoid aglycones have been shown to have chain-breaking antioxidant properties and to quench free radicals, thereby exerting protective effects on macromolecules (24).…”
Section: Discussionmentioning
confidence: 99%
“…With regard to the etiology and prediction of cancer, the technology employed should have wide application to a variety of clinical and laboratory studies in which the status of DNA structure is important. Among such possible applications are studies of the effects of DNA cleaving molecules having selective anti-cancer activity (28,29), DNA damage resulting from radiation (30), antioxidant protection against DNA oxidation (31,32), structural alterations in DNA resulting from hormones (26) and xenobiotics (27), and somatic changes in genes (33).…”
Section: Discussionmentioning
confidence: 99%
“…Among other suggested mechanisms, ROS generation, as indicated by a few reports, may be increased in the presence of certain tetracyclines, e.g., OTC (21,29). However, a role for ROS in the mechanism of OTC action has yet to be clearly established.…”
mentioning
confidence: 99%