Hydride reorientation can occur as a result of vacuum drying or transportation of spent nuclear fuel rods prior to dry cask storage. The elevated temperatures generate high internal gas pressure in the fuel rods, causing d-hydride platelets to precipitate perpendicular to the hoop stress during cooling. Because the loading causes multiaxial stresses, it is of interest to elucidate the role of stress state on the threshold stress for hydride reorientation. To that end, specially designed specimens were used with a range of stress biaxiality ratios (r 1 /r 2) from uniaxial tension (r 1 /r 2 ¼ 0) to near-equibiaxial tension (r 1 /r 2 ¼ 0.8). The threshold stress was determined in each case by matching the major and minor stresses (and thus the local stress state) calculated by finite-element analysis to the hydride microstructures created by the thermomechanical treatment at that specific location. Using cold-worked stress-relieved Zircaloy-4, the results show that as the stress biaxiality ratio increased from uniaxial tension to near-equibiaxial tension, the threshold stress decreased from 155 to 75 MPa. To elucidate the Manuscript