Hydrazides and sulfonylhydrazides of the quinoline series as inhibitors of serum aminooxidase

The role of lipid peroxidation in the possible involvement of membrane-Bound monoamine oxidases in gamma-aminobutyric acid and glucosamine deamination in rat brain

“…In this article, we have estimated the LPO-induced GABA-and GLCAdeaminating activities of modified MAO in samples with isoniazid or two novel potent diamine oxidase inhibitors (Gracheva et al, 1988). As shown in Table 4, deamination of GABA and GLCA, catalyzed by both synaptosomal or mitochondrial MAO, modified under conditions of stimulated LPO, was strongly inhibited by all the compounds studied.…”

“…A selective inhibitor of MAO-A, pyrazidol (2,3,3a,4,5,6-hexahydro-8-methyl-l-H-pyrazino(3,2,1-j,k) carbazol hydrochloride) (Gorkin, 1985b), inhibitors of diamine oxidase activity (HQ-6CA [(hydrazide of 1,2,3,4-tetrahydroquinoline-6-carbonic acid]), and (HQ-2CA [(hydrazide of quinoline-2-carbonic acid]) (Gracheva et al, 1988), or an inhibitor of modified MAO activity, isoniazid (hydrazide of isonicotinic acid), (Gorkin, 1983), was added to the incubation medium, together with one of the substrates. Protein content was determined by Lowry method (Lowry et al, 1951), or biuret method (Gornall et al, 1949) using bovine serum albumin as a standard.…”

Synthesis of 1,2,3,4-Tetrahydroquinolines including Angustureine and Congeneric Alkaloids. A Review

“…5 1,2,3,4-Tetrahydroquinoline-4-carboxylic acid is used in tissue-irrigating solutions. 6 A wide array of other biological activities have been reported, including inter alia inhibition of (H C /K C )-ATPase, 7 blood serum monoamine oxidase, 8 angiotensin I converting enzyme, 9 lipoxygenase, 10 lipid peroxidation, 11 bone resorption, 12 leukotriene synthesis, 13,14 and bacterial dihydrofolate reductase. 15 Relevance to many other areas has been noted.…”

Synthesis, characterization, antibiogram and DNA binding studies of novel Co(II), Ni(II), Cu(II), and Zn(II) complexes of Schiff base ligands with quinoline core

“…The coordination of quinoline has gained increasing attention as antibacterials (Freixas and Span, 1991;Ryoichi et al, 1991), monoamine oxidase inhibitors (Gracheva et al, 1988), and herbicides (Hagen et al, 1988). On the other hand, substituted quinolines are prominent building blocks in both organic and inorganic molecular chemistry with their p-stacking ability and coordination properties.…”