Hydration of AMP and ATP Molecules in Aqueous Solution and Solid Films

Faizullin, Dzhigangir A.; Zakharchenko, N. L.; Zuev, Yu. F.; Puzenko, Alexander; Levy, Evgeniya; Feldman, Yuri

doi:10.3390/ijms141122876

Cited by 10 publications

(3 citation statements)

References 25 publications

(51 reference statements)

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“…Thus, the importance of studying hydration shells was emphasized. Many studies of ATP hydration shells using various approaches were performed. − However, none of these gave a complete solution of the mentioned energetic problem.…”

Section: Introductionmentioning

confidence: 99%

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Key Differences of the Hydrate Shell Structures of ATP and Mg·ATP Revealed by Terahertz Time-Domain Spectroscopy and Dynamic Light Scattering

Penkov

Pen’kova

2021

J. Phys. Chem. B

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ATP is one of the main biological molecules. Many of its biological and physicochemical properties, such as energy capacity of the phosphate bonds, significantly depend on hydration. However, the structure of the hydration shell of the ATP molecule is still a matter of discussion. In this work, the hydration shells of ATP in water and MgCl 2 solutions were examined by terahertz time-domain spectroscopy and dynamic light scattering. Terahertz spectroscopy reveals the distorted water structure in the ATP water solution displaying tightly bound water molecules, which could be explained by the hydration of phosphate groups. Upon ATP binding to a Mg 2+ ion, the situation is principally different: Instead of the distorted water structure, its arranged structure with increased hydrogen bond number is observed. Dynamic light scattering showed that the hydrodynamic diameter of ATP increases by 0.5 nm after Mg 2+ binding. Meanwhile, according the characteristics of scattering, the increase of the shell size occurs via formation of a layer with a refraction coefficient similar to water. This layer can be interpreted as hydration shell differing from unaltered water by increased number of hydrogen bonds.

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Section: Introductionmentioning

confidence: 99%

“…Different methods are used to study the hydration shells of biological molecules, such as NMR, fluorescent spectroscopy, dielectric spectroscopy, , and infrared (IR) spectroscopy . Along with the listed methods, a relatively new and developing method of terahertz (THz) spectroscopy can be mentioned.…”

Section: Introductionmentioning

confidence: 99%

Key Differences of the Hydrate Shell Structures of ATP and Mg·ATP Revealed by Terahertz Time-Domain Spectroscopy and Dynamic Light Scattering

Penkov

Pen’kova

2021

J. Phys. Chem. B

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“…The three analytes of interest ATP, ADP and AMP become negatively charged in solvents with pH values above 6.6 (Table I) (Faizullin et al, 2013). Therefore, CE is an ideal technique for the analysis of the three compounds.…”

Section: Separation Optimisationmentioning

confidence: 99%