Hydrated Sodium Calcium Aluminosilicate: A High Affinity Sorbent for Aflatoxin

Abstract

Aluminas, silicas and aluminosilicates were evaluated for their ability to sorb radiolabeled aflatoxin B1 (AFB1) from aqueous solution (in vitro). Hydrated sodium calcium aluminosilicate (HSCAS) was selected for testing in vivo due to its high affinity for AFB1, because of its stable association with AFB1, and its GRAS (generally recognized as safe) status as an anticaking agent. The HSCAS, when added to the diet of Leghorn and broiler chicks at a level of .5%, significantly diminished the adverse effects of feeding 7.5 mg AFB1/kg of feed. Thus, this agent (and other aluminosilicate congeners) may prove effective in the preventive management of aflatoxicosis.

Evaluation of Antimycotoxin Effects of Humate and Hydrated Sodium Calcium Aluminosilicate on Broilers Toxicated with Aflatoxin

“…Adsorbents used to prevent the gastrointestinal absorption of mycotoxins must form a strong complex and also have a high capacity to prevent saturation (Ramos, and Hernandez 1996). A hydrated sodium calcium aluminosilicate (HSCAS) , the in vitro experiments carried out with radiolabelled aflatoxin B1 by Phillips et al (1988) demonstrated that of 38 different sorbents tested (a variety of aluminas, zeolites, silicas, phyllosilicates and chemically modified phyllosilicates) HSCAS was the aflatoxin B1-adsorbing compound that was able to form the most stable complex with this mycotoxin (with a sorption of greater than 80% of aflatoxin Bl present in the medium). The complex was also stable in water at pH 2,7, and 10 and at temperatures of 25 and 37°C.…”

Adsorption of Aflatoxin B1 in Corn on Natural Zeolite and Bentonite

“…It was also reported that phyllosilicates clay has the ability to chemisorb aflatoxin from aqueous solutions [14]. Some aluminosilicates bind AFB1 in vitro to varying degrees and form complexes of varying strength with AFB1.…”

Influence of Soluble Feed Proteins and Clay Additive Charge Density on Aflatoxin Binding in Ingested Feeds

“…The commercial clay feed additives, Novasil, Novasil plus, AstraBen 20, and Astra-Ben 20A, are bentonites that primarily consist of the smectite group mineral, montmorillonite. Animal feeding studies have demonstrated that Novasil, Novasil plus, Astra-Ben 20, Astra-Ben 20A, Na-bentonite, zeolite, and sepiolite feed additives can effectively reduce or prevent the toxicity caused by feed contaminated with Aspergillus mycotoxins, such as AfB1 (Phillips et al, 1988(Phillips et al, , 1995Scheideler 1993;Schell et al, 1993aSchell et al, , 1993bEdrington et al, 1996;Abdel-Wahhab et al, 1999;Miazzo et al, 2000;Diaz et al, 2004;Pimpukdee et al 2004;Bailey et al, 2006;Fairchild et al, 2008;Magnoli et al, 2008). Ruminant animals, such as cattle and sheep, can tolerate higher aflatoxin levels and longer low-level intake periods than simple-stomached animals (Vincelli et al, 1995).…”