Hydrated Collagen: Where Physical Chemistry, Medical Imaging, and Bioengineering Meet

Momot, Konstantin I.

doi:10.1021/acs.jpcb.2c06217

Cited by 6 publications

(5 citation statements)

References 100 publications

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“…This interaction is responsible for loss of coherence of the water molecules in the hydration shell. Since there is a fast exchange between water molecules in the hydration shell and the tissue bulk water pool the excited magnetization in tissue exhibits a decay characterized by a short T 2 relaxation time 17 . The dipole–dipole interaction is also responsible for the orientation‐dependent signal decay also known as the magic angle effect that occurs in anisotropic collagenous tissues such as articular cartilage (AC) or tendon 17 .…”

Section: Diffusion‐weighted Imagingmentioning

confidence: 99%

“…Since there is a fast exchange between water molecules in the hydration shell and the tissue bulk water pool the excited magnetization in tissue exhibits a decay characterized by a short T 2 relaxation time 17 . The dipole–dipole interaction is also responsible for the orientation‐dependent signal decay also known as the magic angle effect that occurs in anisotropic collagenous tissues such as articular cartilage (AC) or tendon 17 . The T 2 relaxation time together with the resolution needed to image the tissue are the two most important factors to optimize a DWI protocol.…”

Section: Diffusion‐weighted Imagingmentioning

confidence: 99%

“…17 The dipole-dipole interaction is also responsible for the orientation-dependent signal decay also known as the magic angle effect that occurs in anisotropic collagenous tissues such as articular cartilage (AC) or tendon. 17 The T 2 relaxation time together with the resolution needed to image the tissue are the two most important factors to optimize a DWI protocol. Protocol optimization is made by minimizing the echo time for a given b-value and target resolution.…”

Section: Magnetic Resonance Properties Of Musculoskeletal Tissuesmentioning

confidence: 99%

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Applications of Diffusion‐Weighted MRI to the Musculoskeletal System

Raya

Duarte

Wang

et al. 2023

Magnetic Resonance Imaging

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Diffusion‐weighted imaging (DWI) is an established MRI technique that can investigate tissue microstructure at the scale of a few micrometers. Musculoskeletal tissues typically have a highly ordered structure to fulfill their functions and therefore represent an optimal application of DWI. Even more since disruption of tissue organization affects its biomechanical properties and may indicate irreversible damage. The application of DWI to the musculoskeletal system faces application‐specific challenges on data acquisition including susceptibility effects, the low T2 relaxation time of most musculoskeletal tissues (2–70 msec) and the need for sub‐millimetric resolution. Thus, musculoskeletal applications have been an area of development of new DWI methods. In this review, we provide an overview of the technical aspects of DWI acquisition including diffusion‐weighting, MRI pulse sequences and different diffusion regimes to study tissue microstructure. For each tissue type (growth plate, articular cartilage, muscle, bone marrow, intervertebral discs, ligaments, tendons, menisci, and synovium), the rationale for the use of DWI and clinical studies in support of its use as a biomarker are presented. The review describes studies showing that DTI of the growth plate has predictive value for child growth and that DTI of articular cartilage has potential to predict the radiographic progression of joint damage in early stages of osteoarthritis. DTI has been used extensively in skeletal muscle where it has shown potential to detect microstructural and functional changes in a wide range of muscle pathologies. DWI of bone marrow showed to be a valuable tool for the diagnosis of benign and malignant acute vertebral fractures and bone metastases. DTI and diffusion kurtosis have been investigated as markers of early intervertebral disc degeneration and lower back pain. Finally, promising new applications of DTI to anterior cruciate ligament grafts and synovium are presented. The review ends with an overview of the use of DWI in clinical routine.Evidence Level5Technical EfficacyStage 3

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Section: Diffusion‐weighted Imagingmentioning

confidence: 99%

Section: Diffusion‐weighted Imagingmentioning

confidence: 99%

Section: Magnetic Resonance Properties Of Musculoskeletal Tissuesmentioning

confidence: 99%

See 1 more Smart Citation

Applications of Diffusion‐Weighted MRI to the Musculoskeletal System

Raya

Duarte

Wang

et al. 2023

Magnetic Resonance Imaging

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show abstract

“…Although predominantly relying on the susceptibility effect, those previously developed models did not rule out the magic angle effect (MAE) as a potential relaxation mechanism 1,10 . The MAE has been known for more than half a century, 23 and it has been described as a remarkable phenomenon for

T_{2}

(i.e., 1/

R_{2}

) relaxation in highly organized biological tissues 24–26 . Briefly, the MAE arises from nonaveraging proton residual dipolar coupling (RDC) in heterogenous microenvironments, and it depends on the direction of dipolar interactions relative to

B_{0}

.…”

Section: Introductionmentioning

confidence: 99%

“…1,10 The MAE has been known for more than half a century, 23 and it has been described as a remarkable phenomenon for T 2 (i.e., 1/R 2 ) relaxation in highly organized biological tissues. [24][25][26] Briefly, the MAE arises from nonaveraging proton residual dipolar coupling (RDC) in heterogenous microenvironments, and it depends on the direction of dipolar interactions relative to B 0 . To date, most of the basic research and clinical applications on the topic have focused on collagen-rich tissues such as tendon and cartilage.…”

Section: Introductionmentioning

confidence: 99%

Phase‐shifted transverse relaxation orientation dependences in human brain white matter

Pang

2023

NMR in Biomedicine

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This work aimed to demonstrate an essential phase shift ε 0 for better quantifying R 2 and R Ã 2 in human brain white matter (WM), and to further elucidate its origin related to the directional diffusivities from standard diffusion tensor imaging (DTI). ε 0 was integrated into a proposed generalized transverse relaxation model for characterizing previously published R 2 and R Ã 2 orientation dependence profiles in brain WM, and then comparisons were made with those without ε 0 . It was theorized that anisotropic diffusivity direction ε was collinear with an axon fiber subject to all eigenvalues and eigenvectors from an apparent diffusion tensor. To corroborate the origin of ε 0 , R 2 orientation dependences referenced by ε were compared with those referenced by the standard principal diffusivity direction Φ at b-values of 1000 and 2500 (s/mm 2 ). These R 2 orientation dependences were obtained from T 2 -weighted images (b = 0) of ultrahigh-resolution Connectome DTI datasets in the public domain. A normalized root-mean-square error (NRMSE%) and an F-test were used for evaluating curve-fittings, and statistical significance was considered to be a p of 0.05 or less. A phase-shifted model resulted in significantly reduced NRMSE% compared with that without ε 0 in quantifying various R 2 and R Ã 2 profiles, both in vivo and ex vivo at multiple B 0 fields. The R 2 profiles based on Φ manifested a right-shifted phase (ε 0 > 0) at two b-values, while those based on ε became free from ε 0 . For all phase-shifted R 2 and R Ã 2 profiles, ε 0 generally depended on the directional diffusivities by tan À1 D ⊥ =D k À Á , as predicted. In summary, a ubiquitous phase shift ε 0 has been demonstrated as a prerequisite for better quantifying transverse relaxation orientation dependences in human brain WM. Furthermore, the origin of ε 0 associated with the directional diffusivities from DTI has been elucidated. These findings could have a significant impact on interpretations of prior R 2 and R Ã 2 datasets and on future research.

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Conformational and Dynamic Characterization of Collagen Mimic Peptides by NMR Spectroscopy

Xiao

2024

Springer Series in Biomaterials Science and Engineering

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Hydrated Collagen: Where Physical Chemistry, Medical Imaging, and Bioengineering Meet

Abstract: Pd shadowing. Note the 67 nm periodic pattern, commonly referred to as the "D-period". (B) Molecular origin of the periodic crossstriation seen in part A. Reproduced with permission from ref 14.

Cited by 6 publications

References 100 publications

Applications of Diffusion‐Weighted MRI to the Musculoskeletal System

Applications of Diffusion‐Weighted MRI to the Musculoskeletal System

Phase‐shifted transverse relaxation orientation dependences in human brain white matter

Conformational and Dynamic Characterization of Collagen Mimic Peptides by NMR Spectroscopy

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