Hydralazine Hydrochloride: An Alternative Complexometric Reagent for Total Iron Spotometric Determination

Abstract

An alternative spectrophotometric method has been developed for total iron determination using flow injection analysis (FIA). The procedure is based on the coordination reaction between hydralazine and Fe 2+ ions, which results in the formation of a purple complex monitored at 538 nm. For determination of total iron, Fe ). The RSD ((s/ x ) × 100) for a mixed standard containing 0.60 g·ml -1 Fe 2+ and Fe 3+ was 0.10% (n = 10). Recoveries of spiked samples were 94.3% -106.0%. The analytical frequency was 60 h -1 . The effect of possible interferences has been studied. The procedure was successfully applied for analysis of environmental samples. The real samples results were comparable with those obtained by the official method considering a paired t-test and 95% of confidence level.

Determination of Iron in Environmental Water Samples by FIA-TLS

“…The achieved LOD is much lower compared to those achieved for spectrophotometric method (1.07 uM ; in 10 cm long sample cell), thermal lens microscopy (TLM) in batch mode (0.01uM ) and compared to values achieved by TLM-uFIA (36 nM). [23][24] The applicability of FIA-TLS technique was verified by determining iron species concentrations in a real freshwater sample from Vrtojbica creek. The concentration of iron in Vrtojbica creek was determined by the standard addition method.…”

Crystal structure of (E)-1-(2-(thiophen-2-ylmethylene)hydrazinyl)phthalazine hydrochloride–ethanol (1/1), C15H17ClN4OS

“…Hydralazine derivatives act as antioxidant [5], reducing agent [6], anti-microbial [7] anticancer and anti-HIV [8][9][10]. They also have coordination capacity toward some metal ions and can generate similar biological activities by coordination through the nitrogen atoms [11][12][13]. The asymmetric unit contains one 1-(2-(thiophen-2-ylmethylene)-hydrazinyl)phthalazin-2-ium cation, one chloride anion and one molecule of ethanol.…”