Hydatidiform Mole, with Special Reference to Recurrence and Associated Eclampsia

Chesley, Leon C.; Cosgrove, S.A.; Preece, J.

doi:10.1016/s0002-9378(16)39842-8

Cited by 53 publications

(6 citation statements)

References 13 publications

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“…Recurrent molar pregnancy was observed more often when interspersed with early abortion, as compared with interspersion of normal gestation. This finding is in accordance with those of Chesley et al, 4 Endres, 5 Marquez et al, 10 and Morrison. 11 In Mexico, Marquez et al 1 " found one patient with 11 repeated hydatiform moles.…”

supporting

confidence: 93%

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Recurrent Hydatiform Mole

Gitler

Rolon

MacGregor

1971

International Journal of Gynecology & Obstetrics

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supporting

confidence: 93%

“…choriocarcinoma was detected in only one patient. According to the classification of Chesley et al 4 the gestational sequence of molar pregnancy may follow one of these two patterns:…”

mentioning

confidence: 99%

Recurrent Hydatiform Mole

Gitler

Rolon

MacGregor

1971

International Journal of Gynecology & Obstetrics

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“…Despite the ancient clinical recognition of HMs and the presence of several reports describing cases of recurrent moles (15, 43–46) no attempts were made to identify causative genes for the recurrent form until the report by Seoud et al (47) that led to the mapping of the first maternal locus to 19q13.4 (48). At that time, only six other familial cases of RHMs had been reported in the English PubMed literature since 1980 (49–52).…”

Section: The Importance Of Crossing Our Disciplinementioning

confidence: 99%

NLRP7 and the Genetics of Hydatidiform Moles: Recent Advances and New Challenges

Slim

Wallace

2013

Front. Immunol.

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NOD-like receptor proteins (NLRPs) are emerging key players in several inflammatory pathways in Mammals. The first identified gene coding for a protein from this family is Nlrp5 and was originally called Mater for “Maternal Antigen That Mouse Embryos Require” for normal development beyond the two-cell stage. This important discovery was followed by the identification of other NLRPs playing roles in inflammatory disorders and of the first maternal-effect gene in humans, NLRP7, which is responsible for an aberrant form of human pregnancy called hydatidiform mole (HM). In this review, we recapitulate the various aspects of the pathology of HM, highlight recent advances regarding NLRP7 and its role in HM and related forms of reproductive losses, and expand our discussion to other NLRPs with a special emphasis on those with known roles in mammalian reproduction. Our aim is to facilitate the genetic complexity of recurrent fetal loss in humans and encourage interdisciplinary collaborations in the fields of NLRPs and reproductive loss.

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“…hydatidiform mole or Rh isoimmunization is frequently discovered [ 1,4]. Our patient had married her first husband in 1958 at the age of 19 years and had had 4 pregnancies by him.…”

Section: Discussionmentioning

confidence: 80%