Hydatid Disease of the Liver and Associated Hepatocellular Carcinoma

Zöld, Éva; Barta, Zsolt; Zeher, Margit

doi:10.1016/s1542-3565(05)00288-0

Cited by 13 publications

(12 citation statements)

References 4 publications

(3 reference statements)

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“…8 patients received four golden hydatid tests in our study, among which 1 case was strong positive and 2 cases were weakly positive. Positive rate for this examination was far below the reported average level by some researchers that positive rate could be up to 80% in most cases [16,17]. This phenomenon may be explained by the fact that hepatic echinococcosis is always at the senescence stage when patients seek treatment and diagnostic accuracy of the reported hydatid test may be closely associated with echinococcosis viability.…”

Section: Discussionmentioning

confidence: 60%

“…In order to compare the survival time of co-existing patients and HCC patients, 815 HCC patients were also reviewed. Median survival time for HCC patients was 6 month (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). However, that was 8 month (3-90) in the co-existing patients and was much longer than the median survival time of HCC patients (P<0.05), which was closely associated with tumor size, location, TMN stage and hydatid size, location, classification.…”

Section: Survival Analysis Of Relevant Factorsmentioning

confidence: 92%

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Co-existence of hepatocellular carcinoma and cystic echinococcosis

Ran

Yasen

Shao

et al. 2020

Infect Agents Cancer

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Purpose: Coexistence of hepatocellular carcinoma (HCC) and cystic echinococcus (CE) is extremely rare. Echinococcus granulosus may exhibit a protective effect against cancer. Herein, this study aimed to evaluate the possible effects of echinococcal infection on HCC patients. Methods: Three thousand three hundred hepatic CE patients and 815 HCC patients were retrospectively reviewed between January 2010 and December 2018 in Xinjiang, China, and these patients were 1:5 matched according to their sex, age and tumor TMN stage, and only 13 patients coexisted both CE and HCC. Preoperative ultrasonography (US), computed tomography (CT), liver magnetic resonance imaging (MRI) and dot immune-gold filtration assay (DIGFA) were used for preoperative identification and intraoperative specimens from liver resections were pathologically examined for further confirmation. Survival time was analyzed through Cox proportional hazard model analysis. Results: The co-existing incidence rate of two diseases was 0.39%. For these concurrent cases, HCC was all at the advanced stage and CE lesions were inactive. Median survival time for HCC patients was 6 month (1-17). However, it was 8 month (3-90) for the co-existing cases and was much longer than the median survival time of HCC patients (P< 0.05), which was closely associated with tumor size, location, TMN stage and hydatid size, location, classification. Four of the patients underwent surgical intervention and their median survival time was 17 month (3-68). Conclusions: Echinococcus granulosus may elicit a protective effect against the development and progression of HCC, while more basic and clinical researches are needed.

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Section: Discussionmentioning

confidence: 60%

Section: Survival Analysis Of Relevant Factorsmentioning

confidence: 92%

Co-existence of hepatocellular carcinoma and cystic echinococcosis

Ran

Yasen

Shao

et al. 2020

Infect Agents Cancer

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“…Accordingly in our study, metastatic tumours successfully developed in the mice with echinococcosis . In addition, there are several reports on the presence of hydatid disease in patients with cancer . Nevertheless, our results cannot underscore the possible antitumour effects of cross‐reactive immune responses at the initiation phase of carcinogenesis.…”

contrasting

confidence: 53%

Immune system in cancer and hydatid disease: cross‐reactivity vs. immune modulation

Esendağlı

Abbasoğlu

2015

Parasite Immunology

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“…In einer Arbeit wird über einen Fall einer alveolären Echinokokkose der Leber berichtet, in dem klinisch und bildgebend ein HCC präoperativ nicht ausgeschlossen werden konnte, weshalb zur Diagnosesicherung eine Biopsie der Läsion vorgenommen wurde [45]. Bei 3 veröffentlichten Fällen über die Koexistenz eines HCC und einer Echinokokkose lag ein Malignom im Endstadium vor, oder es kam zu fatalen Komplikationen im Zusammenhang mit der Echinokokkose [34,38,40]. In 3 anderen Arbeiten wurde über die erfolgreiche chirurgische Resektion beider Läsionen berichtet [35 -37].…”

Section: Zusammenfassung !unclassified

Zystische Echinokokkose und hepatozelluläres Karzinom – zufällige Koinzidenz? Ein Fallbericht

et al. 2014

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The coincidence of HCC and cystic echinococcosis in the non-cirrhotic liver of a young man is a rare event. Despite resection in healthy tissue multicentric HCC was diagnosed 5 months later. Only few cases of simultaneous occurrence of HCC and echinococcosis have been published so far. Some authors considered echinococcosis as a trigger for HCC. A causal link between both entities has not been demonstrated until now.

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Hydatid Disease of the Liver and Associated Hepatocellular Carcinoma

Cited by 13 publications

References 4 publications

Co-existence of hepatocellular carcinoma and cystic echinococcosis

Co-existence of hepatocellular carcinoma and cystic echinococcosis

Immune system in cancer and hydatid disease: cross‐reactivity vs. immune modulation

Zystische Echinokokkose und hepatozelluläres Karzinom – zufällige Koinzidenz? Ein Fallbericht

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