Hydatid disease of the central nervous system: a review of literature with an emphasis on Latin American countries

Nourbakhsh, Ali; Vannemreddy, Prasad; Minagar, Alireza; Toledo, Eduardo Gonzalez; Palacios, Enrique; Nanda, Anil

doi:10.1179/016164110x12644252260673

Cited by 36 publications

(35 citation statements)

References 44 publications

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“…Preoperative albendazole therapy may effectively reduce the tension of an intracranial hydatid cyst 27 28. Indications for preoperative or postoperative therapy with albendazole or mebendazole include rupture, multiple organ involvement, multiple brain lesions, recurrence and preoperative volume reduction 29 30…”

Section: Discussionmentioning

confidence: 99%

Intracranial hydatid cyst: imaging findings of a rare disease

Taslakian

Darwish

2016

BMJ Case Reports

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Hydatid disease (echinococcosis) is a worldwide zoonosis produced by the larval stage of the Echinococcus tapeworm. The disease is endemic in many parts of the world, particularly in the Middle East, Australia, New Zealand, South America and central and south Europe. Intracranial hydatid disease is considered a rare disease and may be sometimes very difficult to diagnose based on the clinical and laboratory findings. Therefore, it is important to be aware of the condition and the imaging findings even in the non-endemic parts of the world. We report the case of a 12-year-old boy who presented with headache and vomiting for a few months. The mass was totally excised, with no postoperative complications. We present MR spectroscopy (MRS) findings in this operatively proven case of hydatid cyst of the brain. We discuss imaging findings, in particular the findings on MRS, which is rarely reported in the literature.

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Section: Discussionmentioning

confidence: 99%

Intracranial hydatid cyst: imaging findings of a rare disease

Taslakian

Darwish

2016

BMJ Case Reports

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“…AE is also called "parasite cancer" (Xu 2020) [1] and about 80% of AE cases affect the liver, with other organs less frequently infected (Craig 2017) [2] . This disease is mainly prevalent in Asia, Africa, South America, the Middle East, and Australia (Nourbakhsh 2010, Sven 2019) [3,4] . Humans usually become infected after inadvertently eating the eggs of the worm.…”

Section: Introductionmentioning

confidence: 99%

The Effect and Mechanism of ROS-Mediated Activation of NLRP3 Inflammasome in Hepatic Alveolar Echinococcosis

chen

zhang²,

wang

et al. 2020

Preprint

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Background: The NLRP3 inflammasome is a significant component of the innate immune system that plays a vital role in the development of various parasitic diseases. However, its role in hepatic alveolar echinococcosis (HAE) remains unclear. Therefore, we aimed to investigate the NLRP3 inflammasome and its activation mechanism in HAE.Method: We assessed the expression of NLRP3, Caspase-1, interleukin (IL)-1β, and IL-18 in the inflammatory marginal zone and corresponding normal liver tissues of 60 patients with HAE. We used a rat model of HAE to investigate the role of the NLRP3 inflammasome in the inflammatory marginal zone of HAE. Transwell experiments were conducted to investigate the effect of Echinococcus multilocularis in stimulating Kupffer cells and hepatocytes. Further, immunohistochemical staining, western blotting, and ELISA assessed the expression of NLRP3 and Caspase-1, IL-1β, and IL-18, and flow cytometry was used to detect apoptosis and ROS.Results: The activation of NLRP3 inflammasome was intimately associated with the expression of ROS(P<0.05). Inhibition of ROS generation decreased the activation of NLRP3-Caspase-1-IL-1β pathway and mitigated damage to hepatocytes (P <0.01) as well as inflammation (P <0.001) in HAEConclusion: E. multilocularis can induce hepatocytes damage and inflammatory response by activating the ROS-NLRP3-Caspase-1-IL-1β pathway in Kupffer cells, indicating that ROS may be a potential target for the treatment of HAE.

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“…Intracranial epidural hydatid cysts are extremely rare [1][2][3][4][5] and are caused by Echinococcus granulosus. surgery is presently the mainstay in the treatment of intracranial hydatid cysts because of their rapid growth in size which results in increased intracranial pressure and thus an increased risk of cerebral herniation and subsequent death [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…surgery is presently the mainstay in the treatment of intracranial hydatid cysts because of their rapid growth in size which results in increased intracranial pressure and thus an increased risk of cerebral herniation and subsequent death [5][6][7][8]. Although they may be treated with oral albendozole or mebendazole without surgery when they affect other organs in the body, radiological remission of intracranial hydatid cysts has been reported in only a few cases of small diameter cysts without histopathological verification [9].…”

Section: Introductionmentioning

confidence: 99%