Hydatid Disease, an Uncommon Etiology of Death in Forensic Practice

Mahjoub, Yosra; Boussaïd, Marwa; Mesrati, Mohamed Amine; Hadj, Meriem Bel; Limem, Hiba; Abdeljalil, Nouha; Salem, Nidhal Haj; Zakhama, Abdelfattah; Chadly, Ali; Aissaoui, Abir

doi:10.1097/paf.0000000000000750

Cited by 3 publications

(3 citation statements)

References 17 publications

(40 reference statements)

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“… 25 - 26 However, in cases of cardiac hydatidosis, sudden deaths are mostly attributed to major causes such as cardiac arrhythmias, coronary artery diseases, valvular diseases, and cardiomyopathies. 27 , 28 …”

Section: Discussionmentioning

confidence: 99%

Incidental finding of cardiac hydatid cyst during autopsy

Purbey,

Patil,

Bharti

et al. 2024

Autops Case Rep

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Hydatidosis or echinococcosis is an endemic parasitic disease caused by the ingestion of eggs of echinococcal species worldwide. In India, the annual incidence varies from 1 to 200 per one 100,000 hab., with the highest prevalence reported in the Indian states of Andhra Pradesh and Tamil Nadu. The dog is the definitive host, while humans, sheep, and cattle are intermediate hosts. The disease usually involves the liver and lungs, with the kidney and other organs rare involvement. Cardiac hydatidosis is still further rare, seen in 0.2% to 2% of the patients who remain asymptomatic until the development of its complications. Sudden deaths in cardiac echinococcosis are mostly attributed to cardiac arrhythmias, coronary artery diseases, valvular diseases, cardiomyopathies, pericarditis, and cardiac tamponade. We, herein, report a rare case of cardiac hydatid cyst incidentally found during the autopsy of a 26-year-old male who died due to electrical injuries. A single greyish-white cystic mass measuring 1.5cm X 1.2cm was detected on the left anterior ventricular wall 4 cm above the apex and was confirmed microscopically as a hydatid cyst. The cause of death was attributed to external injury.

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Section: Discussionmentioning

confidence: 99%

Incidental finding of cardiac hydatid cyst during autopsy

Purbey,

Patil,

Bharti

et al. 2024

Autops Case Rep

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“…Echinococcosis is a parasitic disease caused by the larvae of Echinococcus tapeworms parasitic on the human body. 1 , 2 , 3 The disease is mainly distributed in the developed areas of animal husbandry in the western of China. Ningxia is also the main epidemic area of echinococcosis.…”

Section: Introductionmentioning

confidence: 99%

Study on the mechanism of miRNAs on liver injury in the condition of Protoscocephalus alveolarus transhepatic portal vein infection

Zhu,

Li,

et al. 2024

Immunity Inflam & Disease

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ObjectiveTo explore the role of miRNA in liver damage caused by Echinococcus multilocularis infection.MethodsSix female C57BL mice were randomly divided into two groups, the control group and the infection group. Mice in the control group were injected with 100 μL PBS through the hepatic portal vein, and mice in the infection group were infected with E. multilocularis via the hepatic portal vein to establish a mouse model of infection. Small RNA sequencing was performed for detecting the expression of miRNAs in the liver of mice infected with 2000 E. multilocularis after 3 months of infection, screen out miRNAs related to liver damage, and verify by RT‐PCR.ResultsSeventy‐one differentially expressed miRNAs were found in the liver in comparison with control, and a total of 36 mouse miRNAs with |FC| >0.585 were screened out, respectively. In addition, Targetscan (V5.0) and miRanda (v3.3a) software were used to predict differential miRNAs target genes and functional enrichment of target genes. Functional annotation showed that “cytokine‐cytokine interaction,” “positive regulation of cytokine production,” “inflammatory response,” and “leukocyte activation” were enriched in the liver of E. multilocularis‐infected mice. Moreover, the pathways “human cytomegalovirus infection,” “cysteine and methionine metabolism,” “Notch signaling pathway,” and “ferroptosis” were involved in liver disease. Furthermore, four miRNAs (mmu‐miR‐30e‐3p, mmu‐miR‐203‐3p, mmu‐miR‐125b‐5p, and mmu‐miR‐30c‐2‐3p) related to liver injury were screened and verified.ConclusionThis study revealed that the expression profiling of miRNAs in the livers was changed after E. multilocularis infection, and improved our understanding of the transcriptomic landscape of hepatic echinococcosis in mice.

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“…Echinococcosis is a parasitic disease caused by the larvae of Echinococcus tapeworms parasitic on the human body [1][2][3] . The disease is mainly distributed in the developed areas of animal husbandry in the western of China.…”

Section: Introductionmentioning

confidence: 99%

Study on the mechanism of miRNAs on liver injury in the condition of protoscocephalus alveolarus transhepatic portal vein infection

Zhu,

Li,

et al. 2024

Preprint

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Echinococcus multiloculasis is a zoonotic parasitic disease caused by Echinococcus multilocularis, which can cause liver injury, but the mechanism of liver injury is still unclear. Here, Echinococcus multilocularis was injected via the hepatic portal vein to establish a mouse model of infection, and high-throughput RNA sequencing was performed for detecting the expression of miRNAs in the liver of mice infected with 2000 Echinococcus multilocularis after 3 months infection, in order to understand the potential molecular mechanism of liver injury caused by Echinococcus multilocularis infection. Overall, 71 differentially expressed miRNAs were found in liver in comparison with control and a total of 36 mouse miRNAs with |FC|>0.585 were screened out, respectively. In addition, Targetscan (V5.0) and miRanda (v3.3a) software were used to predict differential miRNAs target genes and functional enrichment of target genes. Functional annotation showed that “cytokine-cytokine interaction”, “ positive regulation of cytokine production”, “ inflammatory respose”, “ leukocute activation” were enriched in the liver of Echinococcus multilocularis-infected mice. Moreover, the pathways “human cytomegalovirus infection”, “cysteine and methonine metabolism”, “Notch signaling pathway” and “ferroptosis” were involved in liver disease. Furthermore, 4 miRNAs (mmu-miR-30e-3p, mmu-miR-203-3p, mmu-miR-125b-5p and mmu-miR-30c-2-3p) related to liver injury were screened and verified. This study revealed that the expression profiling of miRNAs in the livers was changed after Echinococcus multilocularis infection, and improved our understanding of the transcriptomic landscape of hepatic echinococcosis in mice.

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Hydatid Disease, an Uncommon Etiology of Death in Forensic Practice

Cited by 3 publications

References 17 publications

Incidental finding of cardiac hydatid cyst during autopsy

Incidental finding of cardiac hydatid cyst during autopsy

Study on the mechanism of miRNAs on liver injury in the condition of Protoscocephalus alveolarus transhepatic portal vein infection

Study on the mechanism of miRNAs on liver injury in the condition of protoscocephalus alveolarus transhepatic portal vein infection

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