Hybridization between Aedes aegypti and Aedes mascarensis mosquitoes leads to disruption of male sex determination
Jiangtao Liang,
Lin Kang,
Pawel Michalak
et al.
Abstract:Understanding the sex determination pathway and its disruptions in mosquitoes is critical for the effective control of disease vectors through genetic manipulations based on sex separation. When male hybrids of Aedes aegypti females and Ae. mascarensis males are backcrossed to Ae. aegypti females, a portion of the backcross progeny manifests as males with abnormal sexual differentiation. We discovered a significant correlation between pupal abnormalities and the feminization of subsequent adults exemplified by… Show more
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