Hybrid κ-carrageenan-based polymers showing “schizophrenic” lower and upper critical solution temperatures and potassium responsiveness

Loukotová, Lenka; Bogomolova, Anna; Špírková, Miléna; Štěpánek, Petr; Hrubý, Martin

doi:10.1016/j.carbpol.2019.01.050

Cited by 12 publications

(6 citation statements)

References 25 publications

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“…One interesting feature is that the values of p-fraction of PTEGMA decrease with a temperature above pmax points. This is an indication that the mobility of PTEGMA segments is increasing, which is unusual in comparison with the behavior observed for other thermoresponsive systems where the p-fraction value remains constant after reaching pmax [51,56,60]. This effect is related to the copolymer composition and became more pronounced with the increase of the molar ratio of PLA (see Figures S4 and S5).…”

Section: Temperature Behavior: Dls 1 H Nmr Spectra and Fraction P Of ...supporting

confidence: 59%

“…The p-fraction values start to grow from 22 • C and are divided into two types: one for the hydrophobic part of a chain "a, b, c" (main chain) with high p max (>0.80) at 52 • C and the other for the hydrophilic side chain "d, e" with half lower p max values (≈0.4) at 42 • C. However, independent of the values of p max used for an estimation of the LCST (from the side or the main chain), the addition of the PLA block shifted the LCST of PTEGMA to lower temperature ranges between 32-37 • C. One interesting feature is that the values of p-fraction of PTEGMA decrease with a temperature above p max points. This is an indication that the mobility of PTEGMA segments is increasing, which is unusual in comparison with the behavior observed for other thermo-responsive systems where the p-fraction value remains constant after reaching p max [51,56,60].…”

Section: Temperature Behavior: Dls 1 H Nmr Spectra and Fraction P Of ...supporting

confidence: 55%

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Smart Poly(lactide)-b-poly(triethylene glycol methyl ether methacrylate) (PLA-b-PTEGMA) Block Copolymers: One-Pot Synthesis, Temperature Behavior, and Controlled Release of Paclitaxel

et al. 2023

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This paper introduces a new class of amphiphilic block copolymers created by combining two polymers: polylactic acid (PLA), a biocompatible and biodegradable hydrophobic polyester used for cargo encapsulation, and a hydrophilic polymer composed of oligo ethylene glycol chains (triethylene glycol methyl ether methacrylate, TEGMA), which provides stability and repellent properties with added thermo-responsiveness. The PLA-b-PTEGMA block copolymers were synthesized using ring-opening polymerization (ROP) and reversible addition–fragmentation chain transfer (RAFT) polymerization (ROP-RAFT), resulting in varying ratios between the hydrophobic and hydrophilic blocks. Standard techniques, such as size exclusion chromatography (SEC) and 1H NMR spectroscopy, were used to characterize the block copolymers, while 1H NMR spectroscopy, 2D nuclear Overhauser effect spectroscopy (NOESY), and dynamic light scattering (DLS) were used to analyze the effect of the hydrophobic PLA block on the LCST of the PTEGMA block in aqueous solutions. The results show that the LCST values for the block copolymers decreased with increasing PLA content in the copolymer. The selected block copolymer presented LCST transitions at physiologically relevant temperatures, making it suitable for manufacturing nanoparticles (NPs) and drug encapsulation-release of the chemotherapeutic paclitaxel (PTX) via temperature-triggered drug release mechanism. The drug release profile was found to be temperature-dependent, with PTX release being sustained at all tested conditions, but substantially accelerated at 37 and 40 °C compared to 25 °C. The NPs were stable under simulated physiological conditions. These findings demonstrate that the addition of hydrophobic monomers, such as PLA, can tune the LCST temperatures of thermo-responsive polymers, and that PLA-b-PTEGMA copolymers have great potential for use in drug and gene delivery systems via temperature-triggered drug release mechanisms in biomedicine applications.

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Section: Temperature Behavior: Dls 1 H Nmr Spectra and Fraction P Of ...supporting

confidence: 59%

Section: Temperature Behavior: Dls 1 H Nmr Spectra and Fraction P Of ...supporting

confidence: 55%

Smart Poly(lactide)-b-poly(triethylene glycol methyl ether methacrylate) (PLA-b-PTEGMA) Block Copolymers: One-Pot Synthesis, Temperature Behavior, and Controlled Release of Paclitaxel

et al. 2023

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“…Carrageenan is a water-soluble anionic polysaccharide extracted from red algae, which has a large number of hydroxyl and sulfate groups on its molecular chain [22,23]. The negatively charged carrageenan attracts positively charged silver ions by electrostatic attraction, which facilitates the reduction of Ag ions by hydroxyl groups on the molecular chain [24][25][26]. Elsupikhe R.F.…”

Section: Introductionmentioning

confidence: 99%

Facile and Green Fabrication of Carrageenan-Silver Nanoparticles for Colorimetric Determination of Cu2+ and S2−

et al. 2020

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In the present work, silver nanoparticles (AgNPs) were prepared by a simple and green method using carrageenan as reducing and capping agent. The as-synthesized carrageenan-AgNPs was demonstrated as an effective duel colorimetric sensing for selective and sensitive recognition of Cu2+ and S2−, which could be used to detect these ions with naked eyes. In addition, the possible sensing mechanism was that Cu2+ ions caused serious aggregation of carrageenan-AgNPs, which led to the color change of carrageenan-AgNPs. AgNPs were etched by S2− forming Ag2S, which played an important role in the determination of S2− ions. Furthermore, it has been successfully applied to the determination of Cu2+ and S2− in tap water and lake water, showing its great potential for the analysis of environmental water samples.

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“…PEtOx has been synthesized via cationic ring‐opening polymerization (CROP) 28 . The method suggested for poly(2‐isopropyl‐2‐oxazoline‐ co ‐2‐butyl‐2‐oxazoline) grafting to β‐glucan 29 and to κ‐carrageenan 30 was adjusted to GG‐g‐PEtOx. A key factor for successive PEtOx synthesis followed by its grafting to deprotonated GG is the living nature of polymerization with a minimum number of chain transfer and termination reactions.…”

Section: Introductionmentioning

confidence: 99%

Poly(2‐ethyl‐2‐oxazoline) grafted gellan gum for potential application in transmucosal drug delivery

Lavikainen

Dauletbekova

Toleutay

et al. 2021

Polymers for Advanced Techs

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Gellan gum (GG) has been used to prepare polymeric carriers with prolonged retention on the eye surface for topical ocular drug delivery. In this work, GG was chemically modified with short poly(2‐ethyl‐2‐oxazoline) (PEtOx) chains that were expected to have minimal adhesion to mucosal tissues (mucoadhesion). The choice of synthetic procedure, solvents, and reagents has been dictated by biocompatibility of the materials and possible application in drug delivery. The grafts were synthesized via cationic ring‐opening polymerization and their living chains were attached onto deprotonated gellan backbone. The derivatives with three degrees of grafting were prepared by varying the in‐feed mass ratio of PEtOx grafts over GG. NMR and FT‐IR spectroscopies, thermogravimetric analysis, and SEC evidenced that the grafting had actually taken place. However, a greater diffusion coefficient determined for the copolymer, using diffusion‐ordered spectroscopy (NMR), in relation to the diffusion of the unmodified GG, suggested either partial degradation of the backbone or a more compact structure of the copolymer. GG and its graft copolymers (GG‐g‐PEtOx) were found to be highly biocompatible with cells cultured under their induction at concentration of 1, 0.1 and 0.01 mg/mL demonstrated a physiological morphology, as well as an increase in viability and proliferation.

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Hybrid κ-carrageenan-based polymers showing “schizophrenic” lower and upper critical solution temperatures and potassium responsiveness

Cited by 12 publications

References 25 publications

Smart Poly(lactide)-b-poly(triethylene glycol methyl ether methacrylate) (PLA-b-PTEGMA) Block Copolymers: One-Pot Synthesis, Temperature Behavior, and Controlled Release of Paclitaxel

Smart Poly(lactide)-b-poly(triethylene glycol methyl ether methacrylate) (PLA-b-PTEGMA) Block Copolymers: One-Pot Synthesis, Temperature Behavior, and Controlled Release of Paclitaxel

Facile and Green Fabrication of Carrageenan-Silver Nanoparticles for Colorimetric Determination of Cu2+ and S2−

Poly(2‐ethyl‐2‐oxazoline) grafted gellan gum for potential application in transmucosal drug delivery

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