Hybrid total-body pet scanners—current status and future perspectives

Nadig, Vanessa; Herrmann, Ken; Mottaghy, Felix M.; Schulz, Volkmar

doi:10.1007/s00259-021-05536-4

Cited by 64 publications

(48 citation statements)

References 102 publications

(162 reference statements)

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“…will enable even lower radiation dose, for the PET-part below 1 mSv, and with the upcoming opportunities of combining this with artificial intelligence technologies, the radiation will be even lower. 12,13 Among our cases, 18 FDG-PET/CT confirmed all known localised lesions diagnosed by conventional imaging, for example CT and MRI.…”

Section: Discussionsupporting

confidence: 73%

Unexplained fever in children—Benefits and challenges of FDG‐PET/CT

et al. 2022

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Aim To explore [fluorine‐18]‐fluoro‐2‐deoxy‐d‐glucose positron‐emission‐tomography/computed tomography (18FDG‐PET/CT) in patients where standard investigations were non‐diagnostic. Methods We reviewed medical records of previously healthy children who had 18FDG‐PET/CT performed at Copenhagen University Hospital in 2015–2020 due to unexplained fever. Results Thirty‐five of 819 paediatric 18FDG‐PET/CT were performed due to unexplained fever. The final diagnoses were malignancy (11%), infections (23%), inflammatory diseases (43%) and miscellaneous (26%). 18FDG‐PET/CT was diagnostic in six cases with Takayasu's arteritis, tuberculosis, Langerhans cell histiocytosis and Ewing sarcoma. Sixteen cases had focal 18FDG‐uptake, but 18FDG‐PET/CT could only differentiate malignancy, infection and inflammation in three cases. In six cases with inflammatory diseases and no focal signs, PET/CT was normal except increased non‐specific 18FDG‐uptake in bone marrow and spleen in five cases. One case was false positive (suspicion of appendicitis) and two false negative (leukaemia and inflammatory disease). Conclusion 18FDG‐PET/CT was diagnostic, or contributed to the diagnosis, in several children with unexplained fever referred to a tertiary centre. Challenges comprised (i) only increased non‐specific 18FDG‐uptake in bone marrow and spleen in half of cases with inflammatory diseases, (ii) no differentiation between complicated infections, malignancy and inflammation in most cases with focal processes and (iii) a small risk of false positive and false negative results.

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Section: Discussionsupporting

confidence: 73%

Unexplained fever in children—Benefits and challenges of FDG‐PET/CT

et al. 2022

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“…In the case of visualizing angiogenesis in early, developing RA for diagnostic purposes and monitoring anti-angiogenetic properties of Although both SPECT and PET techniques have deep signal penetration and demonstrate high sensitivity in molecular targets/processes imaging, their spatial resolution is not as high as CT or MRI. However, high contrast resolution and the capability of providing functional images make these two imaging modalities highly attractive, and new technological improvements in PET scanners (total body PET) allow for significant improvement in spatial resolution [50,51]. The feasibility of hybrid imaging systems has facilitated the combination of high sensitivity radionuclide imaging with high-resolution CT imaging, allowing for co-localization of molecular images with anatomical images.…”

Section: Introductionmentioning

confidence: 99%

Systematic Review: Targeted Molecular Imaging of Angiogenesis and Its Mediators in Rheumatoid Arthritis

Khodadust

Ezdoglian

Steinz

et al. 2022

IJMS

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Extensive angiogenesis is a characteristic feature in the synovial tissue of rheumatoid arthritis (RA) from a very early stage of the disease onward and constitutes a crucial event for the development of the proliferative synovium. This process is markedly intensified in patients with prolonged disease duration, high disease activity, disease severity, and significant inflammatory cell infiltration. Angiogenesis is therefore an interesting target for the development of new therapeutic approaches as well as disease monitoring strategies in RA. To this end, nuclear imaging modalities represent valuable non-invasive tools that can selectively target molecular markers of angiogenesis and accurately and quantitatively track molecular changes in multiple joints simultaneously. This systematic review summarizes the imaging markers used for single photon emission computed tomography (SPECT) and/or positron emission tomography (PET) approaches, targeting pathways and mediators involved in synovial neo-angiogenesis in RA.

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“…For example, the BrainPET insert for a 7T Magnetic Resonance Imaging (MRI) system currently being built at the Institute of Neuroscience and Medicine, Forschungszentrum Jülich GmbH is expected to achieve a spatial resolution of <2 mm (Lerche et al 2020) over the entire field-of-view (FOV). Modern whole-body scanners, such as the newly developed Quadra (Nadig et al 2022) and Vision PET-CT scanner from Siemens Healthcare, can also achieve a spatial resolution of close to 3 mm (van Sluis et al 2019, Reddin et al 2018) at the iso-center. The large positron range of non-standard positron emitters, such as 68 Ga and 120 I, cause significant degradation of the PET image, an issue which cannot be neglected for such high-resolution PET scanners.…”

Section: Introductionmentioning

confidence: 99%

“…2020) over the entire field-of-view (FOV). Modern whole-body scanners, such as the newly developed Quadra (Nadig et al . 2022) and Vision PET-CT scanner from Siemens Healthcare, can also achieve a spatial resolution of close to 3 mm (van Sluis et al .…”

Section: Introductionmentioning

confidence: 99%

Accurate 3D Positron Range Correction Method for Heterogeneous Material Densities in PET

Li¹,

Scheins²,

Tellmann³

et al. 2022

Preprint

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Objective: The positron range is a fundamental, detector-independent physical limitation to special resolution in positron emission tomography (PET) as it causes a significant blurring of the reconstructed PET images. A major challenge for positron range correction methods is to provide accurate range kernels that inherently incorporate the generally inhomogeneous stopping power, especially at tissue boundaries. In this work, we propose a novel approach to generate accurate three-dimensional (3-D) blurring kernels both in homogenous and heterogeneous media to improve PET spatial resolution. Approach: In the proposed approach, positron energy deposition was approximately tracked along straight paths, depending on the positron stopping power of the underlying material. The positron stopping power was derived from the attenuation coefficient of 511keV gamma photons according to the available PET attenuation maps. Thus, the history of energy deposition is taken into account within the range of kernels. Special emphasis was placed on facilitating the very fast computation of the positron annihilation probability in each voxel. Results: Positron path distributions of 18F in low-density polyurethane were in high agreement with Geant4 simulation at an annihilation probability larger than 10-2~10-3 of the maximum annihilation probability. The Geant4 simulation was further validated with measured 18F depth profiles in these polyurethane phantoms. The tissue boundary of water with cortical bone and lung was correctly modeled. Residual artifacts from the numerical computations were in the range of 1%. The calculated annihilation probability in voxels shows an overall difference of less than 20% compared to the Geant4 simulation. Significance: The proposed method significantly improves spatial resolution for non-standard isotopes by providing accurate range kernels, even in the case of significant tissue inhomogeneities.

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Hybrid total-body pet scanners—current status and future perspectives

Cited by 64 publications

References 102 publications

Unexplained fever in children—Benefits and challenges of FDG‐PET/CT

Unexplained fever in children—Benefits and challenges of FDG‐PET/CT

Systematic Review: Targeted Molecular Imaging of Angiogenesis and Its Mediators in Rheumatoid Arthritis

Accurate 3D Positron Range Correction Method for Heterogeneous Material Densities in PET

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