Abstract-Location estimation of mobile target is an important research in wireless sensor networks. However, the phenomenon of non line of sight affects the accuracy of location estimating algorithms greatly. In order to improve the accuracy of location estimation of mobile targets, we proposed a game theory based location method algorithm in wireless sensor networks. In the proposed method, we first estimate the initial locations of mobile target with a support vector regression model, and then use game theory to smooth the already estimated locations. In the game model, game based filter and noise generator are two game rivals. The game filter aims to minimize the objective function of the game model, and the noise generator aims to maximize the same objective function. We propose a differential game theory based algorithm for solving the optimal resolution. The experiments show that, the proposed method is more powerful, and can be used to mobile target locating and tracking.