Hybrid skin chips for toxicological evaluation of chemical drugs and cosmetic compounds

Lee, Jong Seung; Kim, Jin; Cui, Baofang; Kim, Su Kyeom; Cho, Sun-A; An, Shi; Cho, Seung‐Woo

doi:10.1039/d1lc00550b

Cited by 11 publications

(5 citation statements)

References 64 publications

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“…As the first line of defense of endogenous antioxidants in the human body, GSH can be regarded as an essential marker indicating OS status and serves as a quantitative toxicological assessment. To illustrate, GSH has been applied in a skin-liver model to quantify the allergic toxicity of topical cosmetics to the liver [166]. Nowadays, several fermentation techniques have solved the common problem of low GSH production yield [167,168].…”

Section: Antioxidant Peptides In the Cosmetic Industrymentioning

confidence: 99%

New Insights into Antioxidant Peptides: An Overview of Efficient Screening, Evaluation Models, Molecular Mechanisms, and Applications

Zhang,

Li,

Quan

et al. 2024

Antioxidants

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Antioxidant peptides are currently a hotspot in food science, pharmaceuticals, and cosmetics. In different fields, the screening, activity evaluation, mechanisms, and applications of antioxidant peptides are the pivotal areas of research. Among these topics, the efficient screening of antioxidant peptides stands at the forefront of cutting-edge research. To this end, efficient screening with novel technologies has significantly accelerated the research process, gradually replacing the traditional approach. After the novel antioxidant peptides are screened and identified, a time-consuming activity evaluation is another indispensable procedure, especially in in vivo models. Cellular and rodent models have been widely used for activity evaluation, whilst non-rodent models provide an efficient solution, even with the potential for high-throughput screening. Meanwhile, further research of molecular mechanisms can elucidate the essence underlying the activity, which is related to several signaling pathways, including Keap1-Nrf2/ARE, mitochondria-dependent apoptosis, TGF-β/SMAD, AMPK/SIRT1/PGC-1α, PI3K/Akt/mTOR, and NF-κB. Last but not least, antioxidant peptides have broad applications in food manufacture, therapy, and the cosmetics industry, which requires a systematic review. This review introduces novel technologies for the efficient screening of antioxidant peptides, categorized with a new vision. A wide range of activity evaluation assays, encompassing cellular models, as well as rodent and non-rodent models, are provided in a comprehensive manner. In addition, recent advances in molecular mechanisms are analyzed with specific cases. Finally, the applications of antioxidant peptides in food production, therapy, and cosmetics are systematically reviewed.

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Section: Antioxidant Peptides In the Cosmetic Industrymentioning

confidence: 99%

New Insights into Antioxidant Peptides: An Overview of Efficient Screening, Evaluation Models, Molecular Mechanisms, and Applications

Zhang,

Li,

Quan

et al. 2024

Antioxidants

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show abstract

“…Légues et al 109 also developed an innovative 3D full-size bioprinted human skin model, which contains immune cells, for screening cosmetic ingredients aimed at reducing or preventing inflammation. Lee et al 110 reported a mixed human skin model capable of performing a detailed toxicological evaluation of drug and cosmetic compounds (Fig. 5c).…”

Section: Toxicological Evaluationmentioning

confidence: 99%

Advancements in microfluidics for skin cosmetic screening

Cheng

Zhang

et al. 2023

Analyst

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“…Furthermore, lactic acid, used in anti-wrinkle cosmetics, administered simultaneously with strontium chloride suppressed neuronal activation. Interestingly, indicators of hepatotoxicity were detected after topical administration of hepatotoxic compounds at lower levels than in liver cell monolayer cultures, demonstrating the role of the skin barrier [ 67 ]. However, the lack of sensitivity studies in some models, together with the variability of patient samples, limits the model.…”

Section: Biological Requirements For Skin-on-chip (Soc) Devicesmentioning

confidence: 99%

Modeling an Optimal 3D Skin-on-Chip within Microfluidic Devices for Pharmacological Studies

et al. 2022

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Preclinical research remains hampered by an inadequate representation of human tissue environments which results in inaccurate predictions of a drug candidate’s effects and target’s suitability. While human 2D and 3D cell cultures and organoids have been extensively improved to mimic the precise structure and function of human tissues, major challenges persist since only few of these models adequately represent the complexity of human tissues. The development of skin-on-chip technology has allowed the transition from static 3D cultures to dynamic 3D cultures resembling human physiology. The integration of vasculature, immune system, or the resident microbiome in the next generation of SoC, with continuous detection of changes in metabolism, would potentially overcome the current limitations, providing reliable and robust results and mimicking the complex human skin. This review aims to provide an overview of the biological skin constituents and mechanical requirements that should be incorporated in a human skin-on-chip, permitting pharmacological, toxicological, and cosmetic tests closer to reality.

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Hybrid skin chips for toxicological evaluation of chemical drugs and cosmetic compounds

Abstract: Hybrid skin models for safety tests of drugs and cosmetics for topical application.

Cited by 11 publications

References 64 publications

New Insights into Antioxidant Peptides: An Overview of Efficient Screening, Evaluation Models, Molecular Mechanisms, and Applications

New Insights into Antioxidant Peptides: An Overview of Efficient Screening, Evaluation Models, Molecular Mechanisms, and Applications

Advancements in microfluidics for skin cosmetic screening

Modeling an Optimal 3D Skin-on-Chip within Microfluidic Devices for Pharmacological Studies

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