Hybrid Renal Cell Carcinomas Containing Histopathologic Features of Chromophobe Renal Cell Carcinomas and Oncocytomas Have Excellent Oncologic Outcomes

Waldert, Matthias; Klatte, Tobias; Haitel, Andrea; Özsoy, Mehmet; Schmidbauer, Joerg; Marberger, Michael; Remzi, Mesut

doi:10.1016/j.eururo.2009.05.009

Cited by 77 publications

(52 citation statements)

References 23 publications

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“…Oncocytomas although may grow quite large do not typically spread to other organs and is curative by surgical resection. However, differentiating renal oncocytomas from RCC by imaging has proven difficult due to their similar imaging features, requiring pathology to make a confident diagnosis [48]. Results from a meta-analysis across 1711 participants and 21 studies have indicated that expression of CK7 is a major immunohistochemical marker for differentiating RCC from oncocytoma [48].…”

Section: Composite Papillary Renal Cell Carcinoma and Oncocytomamentioning

confidence: 99%

“…Mixed papillary and clear cell RCC tumors are considered the single most commonly occurring renal composite tumor [46]. Although most composite RCC chromophobe and oncocytoma tumors are indolent, a small fraction of these tumors may behave more aggressively [48].…”

Section: Genitourinary Composite Tumorsmentioning

confidence: 99%

“…However, differentiating renal oncocytomas from RCC by imaging has proven difficult due to their similar imaging features, requiring pathology to make a confident diagnosis [48]. Results from a meta-analysis across 1711 participants and 21 studies have indicated that expression of CK7 is a major immunohistochemical marker for differentiating RCC from oncocytoma [48]. Oncocytomas enhance avidly and relatively homogeneously during the corticomedullary phase without signs of necrosis or hemorrhage, and may have a low attenuating central stellate scar on CT [59][60][61][62].…”

Section: Composite Papillary Renal Cell Carcinoma and Oncocytomamentioning

confidence: 99%

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Collision and composite tumors; radiologic and pathologic correlation

et al. 2017

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The terms composite and collision tumors have been used interchangeably throughout radiological literature. Both composite and collision tumors involve two morphologically and immunohistochemically distinct neoplasms coexisting within a single organ. However, collision tumors lack the histological cellular intermingling seen in composite tumors. Composite tumors often arise from a common driver mutation that induces a divergent histology from a common neoplastic source while collision tumors may arise from coincidental neoplastic change. The purpose of this review is to provide an overview of abdominal composite and collision tumors by discussing hallmark radiographic and pathological presentations of rare hepatic, renal, and adrenal case studies. A better understanding of the presentation of each lesion is imperative for proper recognition, diagnosis, and management of these unique tumor presentations.

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Section: Composite Papillary Renal Cell Carcinoma and Oncocytomamentioning

confidence: 99%

Section: Genitourinary Composite Tumorsmentioning

confidence: 99%

Section: Composite Papillary Renal Cell Carcinoma and Oncocytomamentioning

confidence: 99%

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Collision and composite tumors; radiologic and pathologic correlation

et al. 2017

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“…Concern for hybrid tumors consisting of oncocytoma juxtaposed with malignant tissue [Waldert et al 2010] caused many surgeons to recommend treatment for all patients despite a biopsy diagnosis of oncocytoma. However, recent series have suggested that hybrid tumors are exceptionally rare.…”

Section: Ability Of Renal Mass Biopsy To Diagnose Renal Cell Cancer Smentioning

confidence: 99%

Percutaneous biopsy for risk stratification of renal masses

Blute

Drewry

Abel

2015

Therapeutic Advances in Urology

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Abstract:The increased use of abdominal imaging has led to identification of more patients with incidental renal masses, and renal mass biopsy (RMB) has become a popular method to evaluate unknown renal masses prior to definitive treatment. Pathologic data obtained from biopsy may be used to guide decisions for treatment and may include the presence or absence of malignant tumor, renal cell cancer subtype, tumor grade and the presence of other aggressive pathologic features. However, prior to using RMB for risk stratification, it is important to understand whether RMB findings are equivalent to pathologic analysis of surgical specimens and to identify any potential limitations of this approach. This review outlines the advantages and limitations of the current studies that evaluate RMB as a guide for treatment decision in patients with unknown renal masses. In multiple series, RMB has demonstrated low morbidity and a theoretical reduction in cost, if patients with benign tumors are identified from biopsy and can avoid subsequent treatment. However, when considering the routine use of RMB for risk stratification, it is important to note that biopsy may underestimate risk in some patients by undergrading, understaging or failing to identify aggressive tumor features. Future studies should focus on developing treatment algorithms that integrate RMB to identify the optimal use in risk stratification of patients with unknown renal masses.

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“…The incidence of hybrid tumors ranges from 2% to 32%. [20][21][22][23] An example is the coincidence of oncocytomas (benign) and synchronous chromophobe renal cell carcinoma for the hybrid tumors. Therefore, the presence of renal cell carcinoma cannot be ruled out by the detection of an oncocytoma in the biopsy.…”

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confidence: 99%

Treatment approaches to small renal masses in patients of advanced age (≥75 years)

Ozcan

Altinova

Atan

2018

Turkish Journal of Urology

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Cite this article as: Özcan MF, Altınova S, Atan A. Treatment approaches to small renal masses in patients of advanced age (≥75 years). Turk J Urol 2018; 44: 281-6. ABSTRACTThe elderly population is increasing in Turkey and across the world. With the frequent use of imaging modalities, the detection rate of coincidental small renal mass has also increased. Since small renal masses are generally not malignant, most of them can be followed up by active surveillance. In the current study, we examined the treatment options that can be offered to elderly patients with small renal masses. The optimum treatment method for patients of advanced age presenting with renal masses should be determined based on the presence of comorbidities such as age, renal function, and tumor characteristics.

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Hybrid Renal Cell Carcinomas Containing Histopathologic Features of Chromophobe Renal Cell Carcinomas and Oncocytomas Have Excellent Oncologic Outcomes

Cited by 77 publications

References 23 publications

Collision and composite tumors; radiologic and pathologic correlation

Collision and composite tumors; radiologic and pathologic correlation

Percutaneous biopsy for risk stratification of renal masses

Treatment approaches to small renal masses in patients of advanced age (≥75 years)

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