Hybrid Release of Mutator Activity and the Genetic Structure of Natural Populations

Rc, Woodruff; JNJr, Thompson

doi:10.1007/978-1-4615-6959-6_3

Cited by 20 publications

(12 citation statements)

References 75 publications

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“…One might expect laboratory lines to be predominantly of this type, since almost any source of variability would be selected against by the researcher or by intense competition in a comparatively homogeneous laboratory culture environment. This expectation fits the available evidence about mutator activity and other components of hybrid dysgenesis in laboratory lines (see reviews in Kidwell eta!., 1977;Thompson and Woodruff, 1978a;Woodruff and Thompson, 1980). Natural populations could, however, tolerate a much higher potential mutation rate.…”

Section: Nomadic Dna and Mutation Ratessupporting

confidence: 84%

“…Mutation rate is negligible in crosses within each strain (Ax A, or B x B). Many such examples have been reported Woodruff, 1978a, 1980;Woodruff and Thompson, 1980). In terms of our model, both lines carry elements of one or more families that are unstabilized in crosses to laboratory lines.…”

Section: Nomadic Dna and Mutation Ratesmentioning

confidence: 77%

“…In the reciprocal cross, wild type females would contribute a cytoplasm capable of stabilizing more elements than inherited from the laboratory strain male, and no transposition would occur. Such reciprocal differences in mutation are well-documented (e.g., OK1 mutator line males crossed to non-MR Canton S females = 6 1/2982 sex-linked visible mutations, 204 per cent; Canton S males crossed to OK1 females 5/4342 mutations, 012 per cent; Woodruff and Thompson, 1980). When expanded to include reciprocal crosses between different natural populations, the level of mutation should be predictable from the level of potential mutator activity in the strains involved (i.e., it should be correlated with the number of transposable elements they carry).…”

Section: Nomadic Dna and Mutation Ratesmentioning

confidence: 95%

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A model for spontaneous mutation in Drosophila caused by transposing elements

Thompson

Woodruff

1981

Heredity

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SUMMARYTransposing genetic elements make up a significant proportion of the DNA of at least some eukaryotes. One of the potential side effects of transposition is a high rate of apparently spontaneous mutation. In this paper we consider some of the evolutionary strategies that might be involved in the suppression of transposition, and we outline a model for the control of spontaneous mutation in terms of the regulation of transposition. Specific predictions are based upon the well-characterized genetics of the mutator system associated with hybrid dysgenesis in Drosophila melanogaster, which has many parallels with the expected behaviour of transposing elements.

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Section: Nomadic Dna and Mutation Ratessupporting

confidence: 84%

Section: Nomadic Dna and Mutation Ratesmentioning

confidence: 77%

Section: Nomadic Dna and Mutation Ratesmentioning

confidence: 95%

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A model for spontaneous mutation in Drosophila caused by transposing elements

Thompson

Woodruff

1981

Heredity

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“…The possibility that some parthenogenetic organisms do have elevated rates of mutation cannot be ruled out, since many (all known parthenogenetic vertebrates) are known to have hybrid origins (Lynch, 1984a). Interracial hybridization often results in a release of mutator activity in Drosophila through a syndrome known as hybrid dysgenesis (Woodruff and Thompson, 1980). As this phenomenon appears to extend to other organisms (cf.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Mutations for Life‐history Characters in an Obligate Parthenogen

1985

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Abstract.-By allowing mutations to accumulate spontaneously in different lines derived from a single female of an obligately parthenogenetic Daphnia, it has become possible to estimate the rate at which new genetic variance for life-history characters arises as well as to identify the average pleiotropic effects of mutant polygenes. The estimated polygenic mutation rates are quite compatible with those available for sexual organisms. The results are therefore in conflict with the hypothesis that parthenogens compensate for the loss of recombination by elevating the mutation rate. Based on these results, it is argued that the rate of phenotypic evolution may be enhanced as much as five-fold by sexuality. However, if dominance or epistatic gene interactions are of major importance, or if the sensitivity to environmental effects is reduced or the rate of polygenic mutation enhanced under asexuality, the full advantage of sex will not be attained and may even be reversed. Regardless ofthese conditions, it is clear that the mutational rate of production of polygenic variation is sufficient to allow significant rates of phenotypic evolution in purely asexual organisms.

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“…Finally, the Oklahoma lines carry mutator factors of the hybrid dysgenesis sytem (Thompson and Woodruff, 1978;Woodruff and Thompson, 1980). Woodruff and Thompson (1977) tested lines 1 to 25 and found all to induce male recombination in the progeny of outcrosses to the sensitive Total 1641 93 399 dp b cn bw tester strain.…”

Section: Discussior'mentioning

confidence: 99%

Polygene polymorphism affecting wing vein formation in a natural population of Drosophila melanogaster

Thoday

Thompson

1984

Heredity

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SUMMARYOne hundred isofemale lines originating from the same (Oklahoma) wild population of Drosophila melanogaster were assayed for cryptic variation capable of producing gaps in wing vein L5 in flies heterozygous for genomes from an enhanced veinlet line.There were very significant differences between isofemale lines, and the Oklahoma population was clearly polymorphic for vein-gap genes of subthreshold expression. Many of the isofemale lines were also segregating for such genes.There were no obvious relationships between this polymorphism and others that have been studied in the Oklahoma lines.

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Hybrid Release of Mutator Activity and the Genetic Structure of Natural Populations

Cited by 20 publications

References 75 publications

A model for spontaneous mutation in Drosophila caused by transposing elements

A model for spontaneous mutation in Drosophila caused by transposing elements

Spontaneous Mutations for Life‐history Characters in an Obligate Parthenogen

Polygene polymorphism affecting wing vein formation in a natural population of Drosophila melanogaster

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