Hybrid reconstruction of the upper limb in a patient with chronic limb ischemia

Argyriou, Christos; Georgiadis, George S.; Mantatzis, Michael; Schoretsanitis, Nikolaos; Antoniou, George Α.; Papadopoulou, Maria Z; Vogiatzaki, Theodosia; Lazarides, Miltos K.

doi:10.1177/1708538114560459

Cited by 1 publication

(1 citation statement)

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“…Further worsening of ischemic injuries can lead to amputation and death. Common reperfusion treatments include intravascular interventional surgery [213], bypass surgery [214], hybrid reconstruction [215], and cell therapy [216]. However, reperfusion leads to metabolic waste that accumulated in the ischemic limb reentering the systemic circulation, which may result in additional organ injury, multiple organ failure, and death [217].…”

Section: Lycopene Attenuatesmentioning

confidence: 99%

Effects of Lycopene Attenuating Injuries in Ischemia and Reperfusion

Guo

Shang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Tissue and organ ischemia can lead to cell trauma, tissue necrosis, irreversible damage, and death. While intended to reverse ischemia, reperfusion can further aggravate an ischemic injury (ischemia-reperfusion injury, I/R injury) through a range of pathologic processes. An I/R injury to one organ can also harm other organs, leading to systemic multiorgan failure. A type of carotenoid, lycopene, has been shown to treat and prevent many diseases (e.g., rheumatoid arthritis, cancer, diabetes, osteoporosis, male infertility, neurodegenerative diseases, and cardiovascular disease), making it a hot research topic in health care. Some recent researches have suggested that lycopene can evidently ameliorate ischemic and I/R injuries to many organs, but few clinical studies are available. Therefore, it is essential to review the effects of lycopene on ischemic and I/R injuries to different organs, which may help further research into its potential clinical applications.

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