“…The operating principle of an integrated optics structure for sensors and biosensors applications is mostly based on exploiting the evanescent field of a guided waveguide mode or based on exploiting the grating couplers [7,8,9,10,11,12,13,14,15]. The evanescent field of a guided waveguide mode penetrates the cover layer and the substrate layer [7,8,9,10,11,12,13,14,15]. Changes in the optical properties (e.g., refractive index or extinction coefficient) and geometric properties (e.g., thickness) of the cover layer affects on the effective refractive index or attenuation coefficient of light into waveguide structure.…”