Hybrid Organic–Nitride Semiconductor Nanostructures for Biosensor Applications

Bertani, Paul; Lu, Wu

doi:10.1002/9783527807369.ch13

Cited by 1 publication

(1 citation statement)

References 80 publications

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“…In the past decades, there has been an emerging interest in developing GaN-based biosensors for applications in biological, pharmaceutical, or environmental monitoring, such as biomarker detection [ 5 ], glucose sensing [ 6 ], and for disease monitoring and clinical diagnosis [ 7 ]. In comparison to conventional semiconductors, such as silicon [ 8 ], GaN was found to be an excellent material for chemical and biological sensing applications, due to its good chemical stability under harsh environmental conditions, its improved thermal stability, attractive optical properties, good electron mobility, fast response time and excellent biocompatibility [ 9 ]. Moreover, its piezoelectric properties allow applications in chemically sensitive field-effect transistor structures, which offers opportunities for the detection of various relevant target molecules, such as glucose or DNA [ 6 , 10 , 11 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Surface Chemistry and Doping Concentrations on Biofunctionalization of GaN/Ga‒In‒N Quantum Wells

Naskar

Schneidereit

Huber

et al. 2020

Sensors

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The development of sensitive biosensors, such as gallium nitride (GaN)-based quantum wells, transistors, etc., often makes it necessary to functionalize GaN surfaces with small molecules or even biomolecules, such as proteins. As a first step in surface functionalization, we have investigated silane adsorption, as well as the formation of very thin silane layers. In the next step, the immobilization of the tetrameric protein streptavidin (as well as the attachment of chemically modified iron transport protein ferritin (ferritin-biotin-rhodamine complex)) was realized on these films. The degree of functionalization of the GaN surfaces was determined by fluorescence measurements with fluorescent-labeled proteins; silane film thickness and surface roughness were estimated, and also other surface sensitive techniques were applied. The formation of a monolayer consisting of adsorbed organosilanes was accomplished on Mg-doped GaN surfaces, and also functionalization with proteins was achieved. We found that very high Mg doping reduced the amount of surface functionalized proteins. Most likely, this finding was a consequence of the lower concentration of ionizable Mg atoms in highly Mg-doped layers as a consequence of self-compensation effects. In summary, we could demonstrate the necessity of Mg doping for achieving reasonable bio-functionalization of GaN surfaces.

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