Hybrid nanofibers from biodegradable polylactide and polythiophene for scaffolds

Llorens, Elena; Pérez‐Madrigal, Maria M.; Armelín, Elaine; Valle, Luís J. del; Puiggalı́, Jordi; Alemán, Carlos

doi:10.1039/c3ra42829j

Cited by 20 publications

(26 citation statements)

References 33 publications

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“…PLA-P3TMA fibers The electrospinning conditions and morphology of PLA-P3TMA fiber mats were examined in our previous study [33]. Scanning electron microscopy (SEM) micrographs evidenced that the incorporation of P3TMA in the electrospinning solution induced some structural changes in the PLA fiber: (1) the fiber diameter decreased slightly; (2) the fiber surface became smoother; and (3) heterogeneous clusters made of P3TMA aggregates appeared inside the fibers.…”

Section: Results and Discussion 31 Topography And Raman Analyses Ofmentioning

confidence: 99%

“…Within this context, it should be noted that the crystallinity and thermal behavior of PLA-P3TMA fibers was previously examined [33]. Quantitative release studies were performed considering PLA-P3TMA matrices loaded with CIP, CHX, TCS and IBU.…”

Section: Drug Release Studymentioning

confidence: 99%

“…Samples will be identified indicating the PLA and P3TMA ratio. According to our previous optimization of the processing conditions [33], PLA electrospun fibers were collected on a target with a deposition distance of 12 cm, applying a voltage of 20 kV with a portable High Voltage Source (model ES30-5W, Gamma High Voltage Research, Ormond Beach (FL), USA) and a flow rate of 4 mL·h -1 . The voltage and flow-rate used to prepare PLA-P3TMA fibers was 25 kV and 4 mL·h -1 , respectively.…”

Section: Preparation Of Pla-p3tma Fibersmentioning

confidence: 99%

“…ability to exchange ions) and wettability properties provided by the CP. The objective of the present work is to show the multifunctionality of scaffolds made of PLA-P3TMA fibers, which is based on the combination of the already known cellular response [33] with their high activity as drug carrier and delivery systems. In order to prove this duality, the encapsulation and delivery of different drugs in PLA-P3TMA systems have been investigated by controlling both the fiber morphology and the composition of the blend.…”

Section: Introductionmentioning

confidence: 99%

“…Martin and co-workers developed electrospun poly (lactide-co-glycolide)-poly(3,4-ethylenedioxythiophene) conductive core-sheath nanofibers (PLGA-PEDOT) able to modulate the release of dexamethasone, an anti-inflammatory drug for the central nervous system [32]. More recently, we designed and synthesized series of linear micro/nanofibers for tissue engineering applications using PLA-P3TMA blends with different compositions [33]. Scaffolds containing P3TMA exhibited enhanced cellular proliferation and adhesion in comparison to those made of pristine PLA.…”

Section: Introductionmentioning

confidence: 99%

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Semiconducting, biodegradable and bioactive fibers for drug delivery

Pérez‐Madrigal¹,

Llorens²,

Valle³

et al. 2016

Express Polym. Lett.

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Abstract. In this work we present the drug release properties and morphological studies of fibers formed by mixing different ratios of poly(lactic acid) (PLA) and poly(3-thiophene methyl acetate) (P3TMA) loaded with four drugs (ciprofloxacin, chlorhexidine dihydrochloride, triclosan and ibuprofen sodium salt). Thus, the main aim of this study is to prove that the excellent cellular response of PLA-P3TMA biocompatible scaffolds can be successfully combined with essential applications as drug carrier and delivery systems. Atomic force microscopic (AFM) and scanning electron microscopic (SEM) micrographs of PLA-P3TMA fibers indicate that the presence of the conducting polymer inside the PLA matrix affects the surface morphology, resulting in a significant increment of the bulk conductivity with respect to PLA fibers. Electrospun hybrid fibers of PLA and P3TMA successfully load both hydrophilic and hydrophobic drugs, the release profiles depending on the release environment (i.e. the release rate increases with the hydrophobicity of the medium). Finally, our results prove that the antibacterial activity of the drugs is not affected by their interactions with the PLA-P3TMA matrix.

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Section: Results and Discussion 31 Topography And Raman Analyses Ofmentioning

confidence: 99%

Section: Drug Release Studymentioning

confidence: 99%

Section: Preparation Of Pla-p3tma Fibersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Semiconducting, biodegradable and bioactive fibers for drug delivery

Pérez‐Madrigal¹,

Llorens²,

Valle³

et al. 2016

Express Polym. Lett.

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Injectable and Conductive Granular Hydrogels for 3D Printing and Electroactive Tissue Support

et al. 2019

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Conductive hydrogels are attractive to mimic electrophysiological environments of biological tissues and toward therapeutic applications. Injectable and conductive hydrogels are of particular interest for applications in 3D printing or for direct injection into tissues; however, current approaches to add conductivity to hydrogels are insufficient, leading to poor gelation, brittle properties, or insufficient conductivity. Here, an approach is developed using the jamming of microgels to form injectable granular hydrogels, where i) hydrogel microparticles (i.e., microgels) are formed with water‐in‐oil emulsions on microfluidics, ii) microgels are modified via an in situ metal reduction process, and iii) the microgels are jammed into a solid, permitting easy extrusion from a syringe. Due to the presence of metal nanoparticles at the jammed interface with high surface area in this unique design, the granular hydrogels have greater conductivity than non‐particle (i.e., bulk) hydrogels treated similarly or granular hydrogels either without metal nanoparticles or containing encapsulated nanoparticles. The conductivity of the granular hydrogels is easily modified through mixing conductive and non‐conductive microgels during fabrication and they can be applied to the 3D printing of lattices and to bridge muscle defects. The versatility of this conductive granular hydrogel will permit numerous applications where conductive materials are needed.

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Multifunctional ternary drug‐loaded electrospun scaffolds

Llorens

Valle

Puiggalı́

2015

J of Applied Polymer Sci

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Multifunctional electrospun scaffolds were prepared from two PLA grades having slightly different D-lactide content (4.2 wt-% and 2.0 wt-%). Triclosan (TCS), ketoprofen (KTP) and p-coumaric acid (CUM) were selected as bactericide, antiinflammatory and antioxidant agents, respectively. Single, binary and ternary drugloaded microfibers having a unimodal diameter distribution could be prepared using a common chloroform:acetone:dimethylsulfoxide mixture and similar operational parameters (i.e. voltage, flow rate and tip-collector distance). FTIR spectra were sensitive to the low amount of drugs loaded and even showed slight differences in PLA conformation. DSC heating scans clearly demonstrated the ability of electrospinning to induce molecular orientation of PLA and also the nucleation effect of incorporated drugs to induce crystallization. Thus, crystallinity of binary drug-loaded scaffolds was significantly higher than observed for unloaded samples.Release behavior of the three drugs from loaded scaffolds and PLA matrices in PBS:ethanol medium was evaluated. A rapid release was always detected, together with partial drug retention which was higher when the more stereoregular PLA matrix was employed. A strong bactericide effect was found when scaffolds were loaded with 3 w/v-% of TCS, but incorporation of a small percentage of KTP (i.e. 1 w/v-%) had a bacteriostatic effect even in the absence of TCS. The inherent cytotoxicity of TCS could be well neutralized by enhancing cell viability by incorporation of CUM and/or KTP.3

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Hybrid nanofibers from biodegradable polylactide and polythiophene for scaffolds

Cited by 20 publications

References 33 publications

Semiconducting, biodegradable and bioactive fibers for drug delivery

Semiconducting, biodegradable and bioactive fibers for drug delivery

Injectable and Conductive Granular Hydrogels for 3D Printing and Electroactive Tissue Support

Multifunctional ternary drug‐loaded electrospun scaffolds

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