Hybrid molecules based on 1,3,5‐triazine as potential therapeutics: A focused review

Abstract

Majority of the representative drugs customarily interact with multiple targets manifesting unintended side effects. In addition, drug resistance and over expression of the cellular efflux‐pumps render certain classes of drugs ineffective. With only a few innovative formulations in development, it is necessary to identify pharmacophores and novel strategies for creating new drugs. The conjugation of dissimilar pharmacophoric moieties to design hybrid molecules with an attractive therapeutic profile is an emerging paradigm in the contemporary drug development regime. The recent decade witnessed the remarkable biological potential of 1,3,5‐triazine framework in the development of various chemotherapeutics. The appending of the 1,3,5‐triazine nucleus to biologically relevant moieties has delivered exciting results. The present review focuses on 1,3,5‐triazine based hybrid molecules in the development of pharmaceuticals.

Recent updates on 1,2,3‐, 1,2,4‐, and 1,3,5‐triazine hybrids (2017–present): The anticancer activity, structure–activity relationships, and mechanisms of action

“…Several triazine hybrids which are exemplified by avapritinib (pyrrolo[2,1‐ f ][1,2,4]triazine, Figure 1), brivanib (pyrrolo[2,1‐ f ][1,2,4]triazine), capmatinib (imidazo[1,2‐ b ][1,2,4]triazine), gedatolisib (1,3,5‐triazine‐urea hybrid), and enasidenib (1,3,5‐triazine‐pyridine hybrid) are already in the market, demonstrating that rational design of triazine hybrids may provide novel anticancer chemotherapeutics. [ 15,16 ]…”

Reaction of 1‐Phenacylidene pyrrolo[3,2,1‐ij]quinolin‐2‐ones with Cyclic/Acyclic Enaminones and the Anticoagulant Activity of Synthesized Pyrrole‐Quinoline Derivatives

“…Currently the trend towards hybrid and multimodal structures containing covalently linked pharmacophore groups prevails in drug design. This combination leads to the possibility of interaction with several protein targets, due to which a synergistic effect is achieved, it provides the possibility of combination therapy using one multimodal agent, minimising undesirable side effects [1a–k] …”

Insight in triazine chromatographic and microbiological analysis: A brief review

“…They possess various important roles in the field of agriculture and medicine such as pesticidal (2), herbicidal (3), antibacterial (4), antifungal (5), antiendotoxin (6), antileishmanial (7), antitubercular (8) and anticancer activity (9). These compounds are interesting from the drug discovery and therapeutics point of view also as a drug nano delivery system (10,11). In Figure 2 the representative structures of some groups of triazine derivatives are shown.…”