CC on regional hydrology, a scenario approach was adopted and three scenarios depicting near-future (2006-2040), mid-future (2041-2070), and farfuture (2071-2100) based on climate were established. The present rate of LU change indicated a reduction in forest cover by 20% and an increase in urbanized areas by 9.5% between 1988 and 2016. It was estimated that forest cover in the catchments may be expected to halve compared to the presentday LU (55% in 2016 to 23% in 2075), along with large-scale conversion to agricultural lands (13.5% in 2016 to 49.5% in 2075). As a result of changes to LU and forecasted climate, it was found that rivers in the Western Ghats of India might face scarcity of fresh water in the next two decades until the year 2040. However, because of large-scale LU conversion toward the year 2050, streamflow in rivers might increase as high as 70.94% at certain times of the year. Although an increase in streamflow is perceived favorable, the streamflow changes during summer and winter may be expected to affect the cropping calendar and crop yield. The changes to streamflow were also linked to a 4.2% increase in ecologically sensitive wetlands of the Aghanashini river catchment.