Hybrid Mesoporous Silica Nanoparticles Grafted with 2-(tert-butylamino)ethyl Methacrylate-b-poly(ethylene Glycol) Methyl Ether Methacrylate Diblock Brushes as Drug Nanocarrier

Abstract

This paper introduces the synthesis of well-defined 2-(tert-butylamino)ethyl methacrylate-b-poly(ethylene glycol) methyl ether methacrylate diblock copolymer, which has been grafted onto mesoporous silica nanoparticles (PTBAEMA-b-PEGMEMA-MSNs) via atom transfer radical polymerization (ATRP). The ATRP initiators were first attached to the MSN surfaces, followed by the ATRP of 2-(tert-butylamino)ethyl methacrylate (PTBAEMA). CuBr2/bipy and ascorbic acid were employed as the catalyst and reducing agent, respectively, to grow a second polymer, poly(ethylene glycol) methyl ether methacrylate (PEGMEMA). The surface structures of these fabricated nanomaterials were then analyzed using Fourier Transform Infrared (FTIR) spectroscopy. The results of Thermogravimetric Analysis (TGA) show that ATRP could provide a high surface grafting density for polymers. Dynamic Light Scattering (DLS) was conducted to investigate the pH-responsive behavior of the diblock copolymer chains on the nanoparticle surface. In addition, multifunctional pH-sensitive PTBAEMA-b-PEGMEMA-MSNs were loaded with doxycycline (Doxy) to study their capacities and long-circulation time.

Evaluation of the Adsorption Efficiency of Glycine-, Iminodiacetic Acid -, and Amino Propyl-Functionalized Silica Nanoparticles for the Removal of Potentially Toxic Elements from Contaminated Water Solution

“…The mesopores size was estimated from the TEM image to be ca. 6 nm, which is larger than those of typical mesoporous silica nanoparticles, due to the pore expanding effect of nonpolar n-hexane [15,36]. All samples of bare MSNs, AP-MSNs, Gly-MSNs, and IDA-MSNs were characterized using BET.…”

Glucosamine Modified the Surface of pH-Responsive Poly(2-(diethylamino)ethyl Methacrylate) Brushes Grafted on Hollow Mesoporous Silica Nanoparticles as Smart Nanocarrier

“…Nam-Kyoung et al reported the synthesis of a novel pH-triggered drug delivery system by grafting poly-L-lysine on the pore entrances of MSNs as a drug gatekeeper [ 31 ]. In addition, the synthesis of a pH-responsive diblock copolymer, i.e., 2-( tert -butylamino)ethyl methacrylate- b -poly(ethylene glycol) methyl ether methacrylate, was reported by Alswieleh et al [ 32 ]. Doxycycline was loaded in the multifunctional pH-responsive diblock copolymer, and the drug could be released from the nanosystem in a relatively controlled manner.…”

Nanoparticles as Drug Delivery Systems of RNAi in Cancer Therapy

“…In general, the versatility of MSNs can be improved by surface functionalization via various types of polymeric materials such as PEG, PEI, and PAMAM [ 153 ]. The silica polymer core/shell nanohybrids will enhance transfer efficiency and have a huge improvement particularly in controlled drug delivery [ 154 ]. Li et al [ 155 ] described a siRNA delivery system (M-MSN_VEGF siRNA@PEI-KALA), the magnetic MSNs (M-MSNs) were functionalized by PEI and peptide (KALA).…”