Hybrid membrane camouflaged copper sulfide nanoparticles for photothermal-chemotherapy of hepatocellular carcinoma

Bai, Jing; Cai, Hongqiao; Yang, Yang; Peng, Fenghui; Song, Mingming; Sun, Kaiju; Yan, Fei; Liu, Yahui

doi:10.1016/j.actbio.2020.04.046

Cited by 73 publications

(54 citation statements)

References 31 publications

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“…Furthermore, photoimmune therapy, chemotherapy, and thermal therapy have been experimentally developed in a liver cancer model. Thus, the clinical application of PDT using the novel PS is promising for hepatobiliary malignancy treatment in the future [102][103][104]. Figure 3 showed our experienced cases of PD imaging in HCC patients.…”

Section: Recent Pdd Using Ala and Icg-based Nir Fluorescence Imagingmentioning

confidence: 99%

Recent Advances in Photodynamic Imaging and Therapy in Hepatobiliary Malignancies: Clinical and Experimental Aspects

et al. 2021

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The therapeutic and diagnostic modalities of light are well known, and derivative photodynamic reactions with photosensitizers (PSs), specific wavelengths of light exposure and the existence of tissue oxygen have been developed since the 20th century. Photodynamic therapy (PDT) is an effective local treatment for cancer-specific laser ablation in malignancies of some organs, including the bile duct. Although curability for extrahepatic cholangiocarcinoma is expected with surgery alone, patients with unresectable or remnant biliary cancer need other effective palliative therapies, including PDT. The effectiveness of PDT for cholangiocarcinoma has been reported experimentally or clinically, but it is not the standard option now due to problems with accompanied photosensitivity, limited access routes of irradiation, tumor hypoxia, etc. Novel derivative treatments such as photoimmunotherapy have not been applied in the field hepatobiliary system. Photodynamic diagnosis (PDD) has been more widely applied in the clinical diagnoses of liver malignancies or liver vascularization. At present, 5-aminolevulinic acid (ALA) and indocyanine green (ICG) dyes are mainly used as PSs in PDD, and ICG has been applied for detecting liver malignancies or vascularization. However, no ideal tools for combining both PDD and PDT for solid tumors, including hepatobiliary malignancies, have been clinically developed. To proceed with experimental and clinical trials, it is necessary to clarify the effective photosensitive drugs that are feasible for photochemical diagnosis and local treatment.

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Section: Recent Pdd Using Ala and Icg-based Nir Fluorescence Imagingmentioning

confidence: 99%

Recent Advances in Photodynamic Imaging and Therapy in Hepatobiliary Malignancies: Clinical and Experimental Aspects

et al. 2021

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“…The anti-VEGFR antibody can kill tumor cells by inhibiting angiogenesis via PI3K/AKT pathways. The nanoparticles avoid the immune system through immune escape, accurately locate HCC cells through liver cancer targeting, and kill tumor cells through PTT and kinase inhibition ( 66 , 67 ).…”

Section: Pttmentioning

confidence: 99%

Photodynamic and Photothermal Therapy of Hepatocellular Carcinoma

2021

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Hepatocellular carcinoma (HCC) is the most common primary liver tumor. It is ranked the sixth most common neoplasm and the third most common cause of cancer mortality. At present, the most common treatment for HCC is surgery, but the 5-year recurrence rates are still high. Patients with early stage HCC with few nodules can be treated with resection or radiofrequency ablation (RFA); while for multinodular HCC, transarterial chemoembolization (TACE) has been the first-line treatment. In recent years, based on medical engineering cooperation, nanotechnology has been increasingly applied to the treatment of cancer. Photodynamic therapy and photothermal therapy are effective for cancer. This paper summarizes the latest progress of photodynamic therapy and photothermal therapy for HCC, with the aim of providing new ideas for the treatment of HCC.

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“… 18–20 To overcome the functional limitations of using single-cell membranes to enhance the functionality of nanomaterials, researchers have developed specialized platforms to prepare hybrid membranes for camouflaging NPs by fusing membranes from different types of cells such as red blood cells and cancer cells, 21 platelets and red blood cells, 22 and cancer cells and macrophages. 23 However, to the best of our knowledge, membranes from platelets and glioma cells have not been used to fabricate hybrid membranes. In this study, we developed tumor-targeting NPs with excellent targeting and immune escape capabilities by fabricating platelet and glioma hybrid membranes to enhance the efficacy of cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

Platelet-Tumor Cell Hybrid Membrane-Camouflaged Nanoparticles for Enhancing Therapy Efficacy in Glioma

Wu¹,

Li²,

Deng³

et al. 2021

IJN

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Purpose Cell membrane-camouflaged nanoparticles (NPs) are drawing increasing attention because their surfaces acquire some characteristics of the cell membranes, making them a unique class of biomimetic materials for diverse applications. Modification of cell membrane or combination of different types of membranes can enhance their functionality. Methods We prepared platelet and tumor cell membrane camouflaged β-mangostin-loaded NPs, which were synthesized with platelet–C6 hybrid biomimetic coating, poly(lactic-co-glycolic acid), and β-mangostin (β-PCNPs). Then, we evaluated their targeting ability and anticancer activity against glioma in vitro and in vivo. Results Biomimetic coating enhanced active drug targeting and immune escape properties of nanocarrier in C6 and THP-1 cells, respectively, which improved their cytotoxicity. β-PCNPs were characterized to study the inherent properties of both source cells. Compared with bare β-NPs, β-PCNPs exhibited high tumor-targeting capability and induced apoptosis of C6 cells in vitro. Similarly, intravenous administration of drug through β-PCNPs resulted in enhanced tumor-targeting and exhibited excellent rate of inhibition of glioma tumor growth in mice. Moreover, the blood circulation time of drug in mice in the β-PCNP group was markedly prolonged and these mice exhibited better outcome than those in the β-NP group. Conclusion These results provide a new strategy of utilizing PCNPs as carriers for drug delivery, which improves the targeting efficiency and therapeutic efficacy of chemotherapeutic agents for glioma therapy.

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Hybrid membrane camouflaged copper sulfide nanoparticles for photothermal-chemotherapy of hepatocellular carcinoma

Cited by 73 publications

References 31 publications

Recent Advances in Photodynamic Imaging and Therapy in Hepatobiliary Malignancies: Clinical and Experimental Aspects

Recent Advances in Photodynamic Imaging and Therapy in Hepatobiliary Malignancies: Clinical and Experimental Aspects

Photodynamic and Photothermal Therapy of Hepatocellular Carcinoma

Platelet-Tumor Cell Hybrid Membrane-Camouflaged Nanoparticles for Enhancing Therapy Efficacy in Glioma

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