Hybrid material of structural DNA with inorganic compound: synthesis, applications, and perspective

Shin, Seung Won; Yuk, Ji Soo; Chun, Sang Hun; Lim, Yong Taik; Um, Soong Ho

doi:10.1186/s40580-019-0211-4

Cited by 15 publications

(9 citation statements)

References 107 publications

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“…Furthermore, drugs like DNA intercalators (e.g., doxorubicin) and nucleic acids (e.g., siRNA, antisense oligonucleotides) can be easily integrated into DNA-based nanocarriers (Li et al, 2011;Lee H. et al, 2012;Zhao et al, 2012;Fakhoury et al, 2014;Rahman et al, 2017). Aided by well-established nucleic acid synthesis and bioconjugation techniques, DNA strands may be incorporated with various functional moieties to enrich the functionality of delivery systems, such as loading a variety of macromolecules (e.g., protein, inorganic particle) or targeting ligands (Li et al, 2019;Shin et al, 2020). These unique properties make DNA-based nanomaterials an attractive drug delivery system.…”

Section: Introductionmentioning

confidence: 99%

Rationally Designed DNA Nanostructures for Drug Delivery

Xia

Wang

2020

Front. Chem.

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DNA is an excellent biological material that has received growing attention in the field of nanotechnology due to its unique capability for precisely engineering materials via sequence specific interactions. Self-assembled DNA nanostructures of prescribed physicochemical properties have demonstrated potent drug delivery efficiency in vitro and in vivo. By using various conjugation techniques, DNA nanostructures may be precisely integrated with a large diversity of functional moieties, such as targeting ligands, proteins, and inorganic nanoparticles, to enrich their functionalities and to enhance their performance. In this review, we start with introducing strategies on constructing DNA nanostructures. We then summarize the biological barriers ahead of drug delivery using DNA nanostructures, followed by introducing existing rational solutions to overcome these biological barriers. Lastly, we discuss challenges and opportunities for DNA nanostructures toward real applications in clinical settings.

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Section: Introductionmentioning

confidence: 99%

Rationally Designed DNA Nanostructures for Drug Delivery

Xia

Wang

2020

Front. Chem.

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“…Another benefit to multi-level featuring is the ability to make surface structures will also present several possibilities in designing bio-inspired surface designs with targeted functionalities 13 , 39 , for example, superhydrophobic, self-cleaning lotus leaf, antifouling and drag reducing shark skin and mollusk shell textures, anti-reflective moth-eye, photonic butterfly wing structures and “water harvesting” micro-bumps like Namib beetle skin. Being able to combine several different functionalities together on the same chip will push us to create more versatile lab-on-a-chip (LOC) devices 18 which will have a massive impact on bio-microfluidics 5 , 58 , 60 – 62 , enabling droplet based small volume sample-reagent testing, biological and chemical assays, point-of-care diagnostics, cell and DNA manipulation 5 , 61 , 62 and testing, separation 35 , sorting 34 , and analysis 36 . These types of multi-level materials will also have varied use in situations requiring surface and absorption enhancements, some of which are water absorption, desalination, carbon capture, battery technology, adsorption enhancement, catalysis, surface tension or capillary force driven transport 6 – 12 etc.…”

Section: Resultsmentioning

confidence: 99%

A novel hardmask-to-substrate pattern transfer method for creating 3D, multi-level, hierarchical, high aspect-ratio structures for applications in microfluidics and cooling technologies

Hazra

Zhang

et al. 2022

Sci Rep

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This letter solves a major hurdle that mars photolithography-based fabrication of micro-mesoscale structures in silicon. Conventional photolithography is usually performed on smooth, flat wafer surfaces to lay a 2D design and subsequently etch it to create single-level features. It is, however, unable to process non-flat surfaces or already etched wafers and create more than one level in the structure. In this study, we have described a novel cleanroom-based process flow that allows for easy creation of such multi-level, hierarchical 3D structures in a substrate. This is achieved by introducing an ultra-thin sacrificial silicon dioxide hardmask layer on the substrate which is first 3D patterned via multiple rounds of lithography. This 3D pattern is then scaled vertically by a factor of 200–300 and transferred to the substrate underneath via a single shot deep etching step. The proposed method is also easily characterizable—using features of different topographies and dimensions, the etch rates and selectivities were quantified; this characterization information was later used while fabricating specific target structures. Furthermore, this study comprehensively compares the novel pattern transfer technique to already existing methods of creating multi-level structures, like grayscale lithography and chip stacking. The proposed process was found to be cheaper, faster, and easier to standardize compared to other methods—this made the overall process more reliable and repeatable. We hope it will encourage more research into hybrid structures that hold the key to dramatic performance improvements in several micro-mesoscale devices.

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“…Inorganic nanomaterials, such as gold nanoparticles and quantum dots, as well as biological molecules, such as proteins, have been arranged using nucleic acid nanostructures. 466,467 Additionally, aptamer docking sites have been integrated into nucleic acid scaffolds to aid in the precise arrangement of many nanomaterials.…”

Section: Enhanced Enzymatic Reactionsmentioning

confidence: 99%

“…Compared to these scaffolds, nucleic acid nanostructures present more predictable and programmable interactions that can precisely position other materials. Inorganic nanomaterials, such as gold nanoparticles and quantum dots, as well as biological molecules, such as proteins, have been arranged using nucleic acid nanostructures. , Additionally, aptamer docking sites have been integrated into nucleic acid scaffolds to aid in the precise arrangement of many nanomaterials.…”

Section: Applications Of Aptamers On Nucleic Acid Nanostructuresmentioning

confidence: 99%

Self-Assembling Nucleic Acid Nanostructures Functionalized with Aptamers

et al. 2021

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Researchers have worked for many decades to master the rules of biomolecular design that would allow artificial biopolymer complexes to self-assemble and function similarly to the diverse biochemical constructs displayed in natural biological systems. The rules of nucleic acid assembly (dominated by Watson–Crick base-pairing) have been less difficult to understand and manipulate than the more complicated rules of protein folding. Therefore, nucleic acid nanotechnology has advanced more quickly than de novo protein design, and recent years have seen amazing progress in DNA and RNA design. By combining structural motifs with aptamers that act as affinity handles and add powerful molecular recognition capabilities, nucleic acid-based self-assemblies represent a diverse toolbox for use by bioengineers to create molecules with potentially revolutionary biological activities. In this review, we focus on the development of self-assembling nucleic acid nanostructures that are functionalized with nucleic acid aptamers and their great potential in wide ranging application areas.

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Hybrid material of structural DNA with inorganic compound: synthesis, applications, and perspective

Cited by 15 publications

References 107 publications

Rationally Designed DNA Nanostructures for Drug Delivery

Rationally Designed DNA Nanostructures for Drug Delivery

A novel hardmask-to-substrate pattern transfer method for creating 3D, multi-level, hierarchical, high aspect-ratio structures for applications in microfluidics and cooling technologies

Self-Assembling Nucleic Acid Nanostructures Functionalized with Aptamers

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