Hybrid material based on hyaluronan hydrogels and poly(l-lactide-co-1,3-trimethylene carbonate) scaffolds toward a cell-instructive microenvironment with long-term in vivo degradability

Reconfigurable scaffolds for adaptive tissue regeneration

“…Thermoresponsive SMPs are representative examples that have been commonly used in forming reconfigurable scaffolds whose shapes could undergo spontaneous transformations upon being placed in physiological environments at body temperature. [31][32][33][34][35][36][37] Some SMPs and hydrogels whose shapes could be deformed upon hydration have also provided candidates for fabricating one-way reconfigurable scaffolds to be triggered by bio-fluids abundant within human bodies. 44,54 Besides, enzyme-responsive SMPs would be promising for forming reconfigurable scaffolds enabling spontaneous shape transformations in specific pathophysiological environments within a relatively long time period (∼7 days).…”

“…31 A PLA-based copolymer, poly( d , l -lactide- co -trimethylene carbonate) (PDLLA- co -TMC) with tuneable T g in the range from 20–45 °C, has been used for preparing reconfigurable nanofibrous scaffolds via electrospinning for bone and vascular tissue engineering. 32,33 Such copolymers could also be suitable for extrusion-based 3D printing, 34 subsequently forming porous scaffolds with initially customized geometries. 35 The polymer blends, such as poly( l -lactic acid) (PLLA)/PCL–diacrylate and PU/gelatin, could also be simply processed to be porous scaffolds via salt leaching or extrusion-based low-temperature 3D printing, which showed semi-interpenetrating networks and excellent shape-memory effects that could be actuated by body temperature.…”

Label-Free Composition Analysis of Supramolecular Polymer–Nanoparticle Hydrogels by Reversed-Phase Liquid Chromatography Coupled with a Charged Aerosol Detector

“…, molecular weight, degradation). − From a detection perspective, the encapsulated payloads are often UV active, while many polymers lack UV chromophores and require derivatization or an alternative detection principle to quantify. Labeling approaches, such as modifying the polymeric components with fluorescent tags or encapsulating fluorescent dyes as payload surrogates, have been developed for tracking the release of polymers and payloads from hydrogels. − However, labeling approaches can complicate hydrogel chemistries and release kinetics, depending on the degree of modification and the properties of the fluorescent modifiers. Tracking the fluorescence intensity may not fully reflect chemical changes in the polymer backbones over time.…”