Hybrid lipid–nanoparticle complexes for biomedical applications

Abstract

This paper reviews five different types of hybrid lipid–nanoparticle complexes (HLNC) with potential applications in biomedical research.

Polymer–Lipid Pharmaceutical Nanocarriers: Innovations by New Formulations and Production Technologies

“…In light of the above, in recent years, an attempt has been made to merge the advantages of polymeric and lipid materials in a single smart carrier system by suitable technique and through a careful selection of biocompatible polymer–lipid combinations, which guarantee a high affinity with biological membranes, allow a controlled drug release over a prolonged period of time, and provide the possibility to co-encapsulate therapeutics with different properties [ 30 , 31 ] (conceptualization schemed in Figure 2 ).…”

“…In light of the above, in recent years, an attempt has been made to merge the advantages of polymeric and lipid materials in a single smart carrier system by suitable technique and through a careful selection of biocompatible polymer-lipid combinations, which guarantee a high affinity with biological membranes, allow a controlled drug release over a prolonged period of time, and provide the possibility to co-encapsulate therapeutics with different properties [30,31] (conceptualization schemed in Figure 2). Among these new blended particles, the most explored and appreciated are the lipid-polymer hybrid nanoparticles (LPHNs) and the liposomes covered with polymers, especially chitosan, carriers capable of loading and transporting a wide range of functional molecules from anticancer to vitamins, peptides, proteins, gene material (see also in following paragraphs), metallic inclusions, cells, and other therapeutics [32] (in Table 3 are several examples of LPHNs loaded with different active ingredients and produced by different preparation methods).…”

Nanoscale covalent organic frameworks as theranostic platforms for oncotherapy: synthesis, functionalization, and applications

“…[11][12][13][14] Rapid developments in nanomaterials and nanotechnology have provided a vast material reservoir for use in cancer nanomedicine, which mainly include mesoporous silica, 15 metal chalcogenides, 16 upconversion materials, 17 MXenes, 18,19 carbonbased materials, 20,21 semiconducting polymers, 22,23 and liposomes. 24 The design, synthesis, and applications of advanced porous materials with specic structures at the micron-and nanoscales have been a research hotspot in various scientic elds; [25][26][27][28][29][30] further, the development of porous materials ranging from traditional inorganic materials (such as zeolites, silicas, and activated carbons) to organic-inorganic hybrid porous materials (such as metal-organic cages (MOCs), 31 coordination polymers (CPs), 32 and metal-organic frameworks (MOFs)). [33][34][35] Among them, MOFs are crystalline materials formed by the selfassembly of organic ligands and metal ions (or clusters) through coordination bonds.…”

Therapeutic lipid-coated hybrid nanoparticles against bacterial infections

“…One novel progeny of a hybrid delivery system, that has been gaining much attention within the scientic community in the recent years, [34][35][36] is the lipid-coated hybrid nanoparticle (LCHNP). LCHNPs can be described as composing of an organic or inorganic nanoparticulate core that is coated with single or multiple layers of lipidsconstituting of simple lipids (i.e.…”