Hybrid Janus Microparticles Achieving Selective Encapsulation for Theranostic Applications via a Facile Solvent Emulsion Method

Lim, Yi Guang Jerome; Poh, Kwok Choon Wilson; Loo, Say Chye Joachim

doi:10.1002/marc.201800801

Cited by 16 publications

(16 citation statements)

References 32 publications

(32 reference statements)

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“…[ 22–25 ] To begin, their baseline interfacial tension values (γ 12 , γ 13 , γ 23 ) at their optimal weight ratios were first measured, and these values are summarized in Table S1 in the Supporting Information. These three polymer combinations have also been shown to be able to form Janus particles by varying weight ratios, [ 20,21 ] and are also documented in Table S2 in the Supporting Information.…”

Section: Figurementioning

confidence: 94%

“…Previous reports have systematically shown that thermodynamics is the main driving force for the formation of Janus particles via the solvent emulsion method, [ 9,20,21 ] In solvent emulsion, there are three interfaces arising from the three phases (phases one and three are polymer solutions, and phase two is the aqueous solution). These interfaces are with respect to the individual polymers and the aqueous solution (γ 12 and γ 23 ), as well as the interface between both polymers (γ 13 ) (Figure S1a, Supporting Information).…”

Section: Figurementioning

confidence: 99%

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Synthesis of Polymeric Janus Superstructures via a Facile Synthesis Method

Lim

Low

Loo

2020

Macromol. Rapid Commun.

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Polymeric Janus particles can be exploited for a myriad of applications. Through the understanding of interfacial tensions, theragnostic agents such as drugs or nanomaterials can be successfully encapsulated into Janus particles without losing their anisotropic structure. In this work, it is reported that how Janus superstructures, as a further extension of the Janus morphology, can be obtained by blending other synthesis parameters into the solvent emulsion process, while adhering to the requirements of the Harkin's spreading coefficient (HSC) theory. Designing such unique structures for drug delivery can provide a broader range of possibilities and applications beyond conventional Janus particles.

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Section: Figurementioning

confidence: 94%

Section: Figurementioning

confidence: 99%

Synthesis of Polymeric Janus Superstructures via a Facile Synthesis Method

Lim

Low

Loo

2020

Macromol. Rapid Commun.

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“…Further techniques for the fabrication of biogenic JPs follow very diverse approaches, such as electrohydrodynamic co-jetting [45], double emulsion solvent evaporation [46], single-step solvent emulsion [43], and polymerization [52] and template-based methods [32], and are rather hardly represented in the literature.…”

Section: Aspects Of Environmental Sustainabilitymentioning

confidence: 99%

“…Another more advanced possibility is the separation of JPs by magnetic fields, which can be enabled by the use of ferromagnetic materials such as Fe 3 O 4 or nickel in the Heparin Chitosan-heparin capsules via layer-by-layer technique partially coated with a gold layer for photothermal thrombus therapy [40] Poly(lysine) Self-propelled Janus swimmers modified with PLL, PEGylated PLL, Pt NPs, and glucose oxidase [41] Inorganic components Seawater-driven magnesium Janus micromotors with a nickel-gold bilayer patch for environmental applications [42] Poly(lactic acid) (PLA) PLA-and PLGA-containing JPs via single-step solvent emulsion technique for encapsulation of therapeutic and diagnostic agents PLA-PLGA JPs via flow-focusing glass microfluidic devices for drug delivery [43] [44]…”

Section: Recovery and Recycling Of Janus Particlesmentioning

confidence: 99%

Janus particles: from concepts to environmentally friendly materials and sustainable applications

2020

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Janus particles represent a unique group of patchy particles combining two or more different physical or chemical functionalities at their opposite sides. Especially, individual Janus particles (JPs) with both chemical and geometrical anisotropy as well as their assembled layers provide considerable advantages over the conventional monofunctional particles or surfactant molecules offering (a) a high surface-to-volume ratio; (b) high interfacial activity; (c) target controlling and manipulation of their interfacial activity by external signals such as temperature, light, pH, or ionic strength and achieving switching between stable emulsions and macro-phase separation; (d) recovery and recycling; (e) controlling the mass transport across the interface between the two phases; and finally (f) tunable several functionalities in one particle allowing their use either as carrier materials for immobilized catalytically active substances or, alternatively, their site-selective attachment to substrates keeping another functionality active for further reactions. All these advantages of JPs make them exclusive materials for application in (bio-)catalysis and (bio-)sensing. Considering "green chemistry" aspects covering biogenic materials based on either natural or fully synthetic biocompatible and biodegradable polymers for the design of JPs may solve the problem of toxicity of some existing materials and open new paths for the development of more environmentally friendly and sustainable materials in the very near future. Considering the number of contributions published each year on the topic of Janus particles in general, the number of contributions regarding their environmentally friendly and sustainable applications is by far smaller. This certainly pinpoints an important challenge and is addressed in this review article. The first part of the review focuses on the synthesis of sustainable biogenic or biocompatible Janus particles, as well as strategies for their recovery, recycling, and reusability. The second part addresses recent advances in applications of biogenic/biocompatible and non-biocompatible JPs in environmental and biotechnological fields such as sensing of hazardous pollutants, water decontamination, and hydrogen production. Finally, we provide implications for the rational design of environmentally friendly and sustainable materials based on Janus particles.

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“…Both polymers are known to be biocompatible and pose no issues concerning biodegradability, bioaccumulation, and ecotoxicity. 25,26 Due to their biocompatibility, the two polymers are widely used in medical elds as well as in cosmetics as lmforming agents. 25,27,28 In our previous research, we discovered that UV-absorbing property of PS was improved when electronirradiated.…”

Section: Introductionmentioning

confidence: 99%