Hybrid imaging of prompt x-rays and induced positrons using a pinhole gamma camera during and after irradiation of protons

Yamamoto, Seiichi; Watabe, Hiroshi; Nakanishi, Keiji; Yabe, Takuya; Yamaguchi, Mitsutaka; Kawachi, Naoki; Kamada, Kei; Yoshikawa, Akira; Islam, Md. Rafiqul; Miyake, Masakazu; Tanaka, Kazuo; Kataoka, J.

doi:10.1088/1361-6560/acd2a2

Cited by 1 publication

(1 citation statement)

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“…A direct comparison of the performances of these three methods would be valuable to understand their advantages and disadvantages as well as to create possible combinations to compensate for the disadvantages of each method. In previous research, a system to measure prompt gamma photons and positron distribution was proposed (Choi L et al 2020, Parodi et al 2023 and a system to measure prompt x-ray and positron distribution was developed (Yamamoto et al 2023).…”

Section: Introductionmentioning

confidence: 99%

A triple-imaging-modality system for simultaneous measurements of prompt gamma photons, prompt x-rays, and induced positrons during proton beam irradiation

Yamamoto,

Watabe,

Nakanishi

et al. 2024

Phys. Med. Biol.

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Objective. Prompt gamma photon, prompt x-ray, and induced positron imaging are possible methods for observing a proton beam’s shape from outside the subject. However, since these three types of images have not been measured simultaneously nor compared using the same subject, their advantages and disadvantages remain unknown for imaging beam shapes in therapy. To clarify these points, we developed a triple-imaging-modality system to simultaneously measure prompt gamma photons, prompt x-rays, and induced positrons during proton beam irradiation to a phantom. Approach. The developed triple-imaging-modality system consists of a gamma camera, an x-ray camera, and a dual-head positron emission tomography (PET) system. During 80 MeV proton beam irradiation to a polymethyl methacrylate (PMMA) phantom, imaging of prompt gamma photons was conducted by the developed gamma camera from one side of the phantom. Imaging of prompt x-rays was conducted by the developed x-ray camera from the other side. Induced positrons were measured by the developed dual-head PET system set on the upper and lower sides of the phantom. Main results. With the proposed triple-imaging-modality system, we could simultaneously image the prompt gamma photons and prompt x-rays during proton beam irradiation. Induced positron distributions could be measured after the irradiation by the PET system and the gamma camera. Among these imaging modalities, image quality was the best for the induced positrons measured by PET. The estimated ranges were actually similar to those imaged with prompt gamma photons, prompt x-rays and induced positrons measured by PET. Significance. The developed triple-imaging-modality system made possible to simultaneously measure the three different beam images. The system will contribute to increasing the data available for imaging in therapy and will contribute to better estimating the shapes or ranges of proton beam.

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Section: Introductionmentioning

confidence: 99%