Hybrid Imaging Agents for Pretargeting Applications Based on Fusarinine C—Proof of Concept

Summer, Dominik; Petřík, Miloš; Mayr, Sonja; Hermann, Martin; Kaeopookum, Piriya; Pfister, Joachim; Klingler, Maximilian; Rangger, C.; Haas, Hubertus; Decristoforo, Clemens

doi:10.3390/molecules25092123

Cited by 9 publications

(10 citation statements)

References 20 publications

(12 reference statements)

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“…Because TCO exhibits greater in vivo stability than Tz, the overwhelming majority of IEDDA-based pretargeting strategies employ a TCO-modified immunoconjugate alongside a Tz-bearing radioligand (Figure ). Since our last review, a remarkable surge in the field has yielded pretargeting systems featuring radioligands labeled with gamma-emitters (i.e., 99m Tc and 111 In), − β + -emitters (i.e., 68 Ga, 18 F, 64 Cu, 44 Sc, and 89 Zr), ,− β – -emitters (i.e., 177 Lu and 67 Cu), − and α-emitters (i.e., 212 Pb, 211 At, and 225 Ac). , …”

Section: The Inverse Electron-demand Diels–alder Reactionmentioning

confidence: 99%

Click Chemistry and Radiochemistry: An Update

Bauer,

Cornejo,

Hoang

et al. 2023

Bioconjugate Chem.

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The term "click chemistry" describes a class of organic transformations that were developed to make chemical synthesis simpler and easier, in essence allowing chemists to combine molecular subunits as if they were puzzle pieces. Over the last 25 years, the click chemistry toolbox has swelled from the canonical copper-catalyzed azide−alkyne cycloaddition to encompass an array of ligations, including bioorthogonal variants, such as the strain-promoted azide−alkyne cycloaddition and the inverse electron-demand Diels−Alder reaction. Without question, the rise of click chemistry has impacted all areas of chemical and biological science. Yet the unique traits of radiopharmaceutical chemistry have made it particularly fertile ground for this technology. In this update, we seek to provide a comprehensive guide to recent developments at the intersection of click chemistry and radiopharmaceutical chemistry and to illuminate several exciting trends in the field, including the use of emergent click transformations in radiosynthesis, the clinical translation of novel probes synthesized using click chemistry, and the advent of click-based in vivo pretargeting.

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Section: The Inverse Electron-demand Diels–alder Reactionmentioning

confidence: 99%

Click Chemistry and Radiochemistry: An Update

Bauer,

Cornejo,

Hoang

et al. 2023

Bioconjugate Chem.

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“…Introduction of fluorescent dye (185) to produce a hybrid imaging modality resulted in rapid uptake in A. fumigatus in vitro, and in an infected lung model in rats showed high fluorescent signal levels that were comparable to a PET/CT scan. This demonstrates the potential applicability of siderophores for hybrid imaging, with possible applications in surgical procedures and bioluminescence in humans (186). A group of researchers in the UK did some preliminary in vitro uptake of [ 68 Ga]Ga-ferrichrome C (a fungal siderophore) using E. coli in iron-deficient medium, and in vascular stents incubated with E. coli cells (187).…”

Section: Recent Development Of Siderophore Based Metal Chelatorsmentioning

confidence: 99%

Radiometal chelators for infection diagnostics

Akter

Lyons²,

Mehra³

et al. 2023

Front. Nucl. Med.

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wInfection of native tissues or implanted devices is common, but clinical diagnosis is frequently difficult and currently available noninvasive tests perform poorly. Immunocompromised individuals (for example transplant recipients, or those with cancer) are at increased risk. No imaging test in clinical use can specifically identify infection, or accurately differentiate bacterial from fungal infections. Commonly used [18F]fluorodeoxyglucose (18FDG) positron emission computed tomography (PET/CT) is sensitive for infection, but limited by poor specificity because increased glucose uptake may also indicate inflammation or malignancy. Furthermore, this tracer provides no indication of the type of infective agent (bacterial, fungal, or parasitic). Imaging tools that directly and specifically target microbial pathogens are highly desirable to improve noninvasive infection diagnosis and localization. A growing field of research is exploring the utility of radiometals and their chelators (siderophores), which are small molecules that bind radiometals and form a stable complex allowing sequestration by microbes. This radiometal-chelator complex can be directed to a specific microbial target in vivo, facilitating anatomical localization by PET or single photon emission computed tomography. Additionally, bifunctional chelators can further conjugate therapeutic molecules (e.g., peptides, antibiotics, antibodies) while still bound to desired radiometals, combining specific imaging with highly targeted antimicrobial therapy. These novel therapeutics may prove a useful complement to the armamentarium in the global fight against antimicrobial resistance. This review will highlight current state of infection imaging diagnostics and their limitations, strategies to develop infection-specific diagnostics, recent advances in radiometal-based chelators for microbial infection imaging, challenges, and future directions to improve targeted diagnostics and/or therapeutics.

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“…Table 2) [67]. Despite their similar thermodynamic stability (Alternative macrocyclic chelators [69][70][71][72][73][74] and acyclic chelators [70,[75][76][77][78][79] have been developed for 89 Zr. Pandya et al were one of the first groups to label DOTA with 89 Zr [69], and more recently, they have extended the application to other polyazamacrocycles [74].…”

Section: Novel Chelators For 89 Zrmentioning

confidence: 99%