Hybrid hydrogels derived from renewable resources as a smart stimuli responsive soft material for drug delivery applications

Singh, Vandana; Prasad, Yadavali Siva; Rachamalla, Arun Kumar; Rebaka, Vara Prasad; Banoo, Tohira; Maheswari, C. Uma; Sridharan, Vellaisamy; Lalitha, Krishnamoorthy; Nagarajan, Subbiah

doi:10.1039/d1ra08447j

Cited by 5 publications

(4 citation statements)

References 52 publications

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“…Indeed, the significance of soft materials in various sectors further motivated researchers to investigate these fascinating materials. In this context, our research group has reported the design, synthesis, and potential applications of pyrene-based amphiphiles. ,− In an attempt to understand the bottom-up assembly of DPSC, initially, we have synthesized DPSC from D-sorbitol and pyrene-1-carboxaldehyde using relatively a simple procedure given in Scheme . ,− In 1 H NMR spectra, the presence of a singlet at δ = 6.45 ppm and a peak at δ = 99 ppm in the 13 C NMR spectrum confirms the formation of acetal in DPSC. After the product formation was confirmed by various spectral techniques, the supramolecular assembly of DPSC is studied.…”

Section: Resultsmentioning

confidence: 99%

“…In this context, our research group has reported the design, synthesis, and potential applications of pyrene-based amphiphiles. 8 , 58 − 68 In an attempt to understand the bottom-up assembly of DPSC, initially, we have synthesized DPSC from D-sorbitol and pyrene-1-carboxaldehyde using relatively a simple procedure given in Scheme 1 . 40 , 69 − 75 In 1 H NMR spectra, the presence of a singlet at δ = 6.45 ppm and a peak at δ = 99 ppm in the 13 C NMR spectrum confirms the formation of acetal in DPSC.…”

Section: Resultsmentioning

confidence: 99%

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Remediation of Dyes Using Supramolecular Material Derived from Carbohydrate Based π-Gelator Using the Bottom-Up Assembly Approach

Singh,

Lalitha,

Maheswari

et al. 2024

ACS Omega

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As a consequence of rapid population growth, the earth has faced numerous environmental sustainability issues and crises, water pollution is one of the important points of concern because of industrialization. In particular, effluents discharged from dying industries are rated top among the various industrial effluents, especially by their volume and composition. Annually >7.5 × 10 5 metric tons of different dyes are produced and consumed in different industries. In order to dye 1 kg of fabric, approximately 100−150 L of water is required, and after the dying process, it is discharged as an effluent either on a landfill or in water bodies. It is our responsibility to conserve environmental sustainability. In this line, we have developed a simple protocol to generate carbohydrate-based amphiphile using D-sorbitol, and pyrene-1-carboxaldehyde in good yield. This carbohydrate-based π-gelator is prone to forming a gel in various solvents and oils by the bottom-up assembly process. Morphological analysis of the self-assembled structure was identified by using optical microscopy and SEM. The viscoelastic behavior of the gel was examined by using rheology. In this paper, we explored the dye adsorption and desorption characteristics of the gel. Further, we have developed a cartridge based on cellulose using a template-assisted assembly phenomenon and demonstrated its potential in adsorbing dyes such as methylene blue, crystal violet, rhodamine B, and Congo red.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Remediation of Dyes Using Supramolecular Material Derived from Carbohydrate Based π-Gelator Using the Bottom-Up Assembly Approach

Singh,

Lalitha,

Maheswari

et al. 2024

ACS Omega

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“…These functionalized gelatin complexes could provide both structural and bioactive functions if incorporated into a bigel [ 103 ]. Using multiple gelators to co-structure the gels can modulate the mechanical properties of the gels and even provide additional release triggers [ 98 , 104 ]. Co-polymer gels (e.g., gelatin–agar-based co-hydrogels) can be achieved by tailoring the composition of bio-compatible gelators [ 54 ].…”

Section: Future Directions and Conclusionmentioning

confidence: 99%

Bigels as Delivery Systems: Potential Uses and Applicability in Food

Francavilla

Corradini

Joye

2023

Gels

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Bigels have been mainly applied in the pharmaceutical sector for the controlled release of drugs or therapeutics. However, these systems, with their intricate structures, hold great promise for wider application in food products. Besides their classical role as carrier and target delivery vehicles for molecules of interest, bigels may also be valuable tools for building complex food structures. In the context of reducing or even eliminating undesirable (but often highly functional) food components, current strategies often critically affect food structure and palatability. The production of solid fat systems that are trans-fat-free and have high levels of unsaturated fatty acids is one of the challenges the food industry currently faces. According to recent studies, bigels can be successfully used as ingredients for total or partial solid fat replacement in complex food matrices. This review aims to critically assess current research on bigels in food and pharmaceutical applications, discuss the role of bigel composition and production parameters on the characteristics of bigels and further expand the use of bigels as solid fat replacers and functional food ingredients. The hydrogel:oleogel ratio, selected gelators, inclusion of surfactants and encapsulation of molecules of interest, and process parameters (e.g., temperature, shear rate) during bigel production play a crucial role in the bigel’s rheological and textural properties, microstructure, release characteristics, biocompatibility, and stability. Besides exploring the role of these parameters in bigel production, future research directions for bigels in a food context are explored.

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“…Because of their broad range of applicational potential, researchers have been studying hydrogels for years. The biomedical and pharmaceutical industries have primarily implemented hydrogels as delivery systems [4,5], scaffolds for cell cultivation [6], and tissue engineering [7]. However, when it comes to the food industry, the implementation of hydrogels is constrained by restrictions on the use of certain ingredients that need to be food-grade, generally recognized as safe (GRAS) by the Food and Drug Administration (FDA) in the USA and included in the EU list of permitted food additives laid down in Regulation EC 1333/2008.…”

Section: Introductionmentioning

confidence: 99%

Binary Hydrogels: Induction Methods and Recent Application Progress as Food Matrices for Bioactive Compounds Delivery—A Bibliometric Review

Hilal

Florowska

Wroniak

2023

Gels

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Food hydrogels are biopolymeric materials made from food-grade biopolymers with gelling properties (proteins and polysaccharides) and a 3D network capable of incorporating large amounts of water. They have sparked considerable interest because of their potential and broad application range in the biomedical and pharmaceutical sectors. However, hydrogel research in the field of food science is still limited. This knowledge gap provides numerous opportunities for implementing their unique properties, such as high water-holding capacity, moderated texture, compatibility with other substances, cell biocompatibility, biodegradability, and high resemblance to living tissues, for the development of novel, functional food matrices. For that reason, this article includes a bibliometric analysis characterizing research trends in food protein–polysaccharide hydrogels (over the last ten years). Additionally, it characterizes the most recent developments in hydrogel induction methods and the most recent application progress of hydrogels as food matrices as carriers for the targeted delivery of bioactive compounds. Finally, this article provides a future perspective on the need to evaluate the feasibility of using plant-based proteins and polysaccharides to develop food matrices that protect nutrients, including bioactive substances, throughout processing, storage, and digestion until they reach the specific targeted area of the digestive system.

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Hybrid hydrogels derived from renewable resources as a smart stimuli responsive soft material for drug delivery applications

Abstract: The design and synthesis of amphiphilic molecules play a crucial role in fabricating smart functional materials via self-assembly.

Cited by 5 publications

References 52 publications

Remediation of Dyes Using Supramolecular Material Derived from Carbohydrate Based π-Gelator Using the Bottom-Up Assembly Approach

Remediation of Dyes Using Supramolecular Material Derived from Carbohydrate Based π-Gelator Using the Bottom-Up Assembly Approach

Bigels as Delivery Systems: Potential Uses and Applicability in Food

Binary Hydrogels: Induction Methods and Recent Application Progress as Food Matrices for Bioactive Compounds Delivery—A Bibliometric Review

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