Hybrid Helical Magnetic Microrobots Obtained by 3D Template‐Assisted Electrodeposition

Zeeshan, Muhammad; Grisch, Roman; Pellicer, Eva; Sivaraman, Kartik M.; Peyer, Kathrin E.; Sort, Jordi; Özkale, Berna; Sakar, Mahmut Selman; Nelson, Bradley J.; Pané, Salvador

doi:10.1002/smll.201302856

Cited by 135 publications

(118 citation statements)

References 15 publications

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“…In the multi-robot perspective, each individual robot could be either identical (i.e., homogeneous) with the same functions or different (i.e., heterogeneous) with varying functionality [48]. The team could move deterministically or stochastically using on-board or off-board (remote) actuation methods [48], [136], [138]–[140]. As locomotion, they could swim, crawl, roll, spin, or hop [30], [33], [50], [61], [136], [138], [141].…”

Section: Challenges and Emerging Concepts In Miniaturized Biomedmentioning

confidence: 99%

Biomedical Applications of Untethered Mobile Milli/Microrobots

et al. 2015

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Untethered robots miniaturized to the length scale of millimeter and below attract growing attention for the prospect of transforming many aspects of health care and bioengineering. As the robot size goes down to the order of a single cell, previously inaccessible body sites would become available for high-resolution in situ and in vivo manipulations. This unprecedented direct access would enable an extensive range of minimally invasive medical operations. Here, we provide a comprehensive review of the current advances in biome dical untethered mobile milli/microrobots. We put a special emphasis on the potential impacts of biomedical microrobots in the near future. Finally, we discuss the existing challenges and emerging concepts associated with designing such a miniaturized robot for operation inside a biological environment for biomedical applications.

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Section: Challenges and Emerging Concepts In Miniaturized Biomedmentioning

confidence: 99%

Biomedical Applications of Untethered Mobile Milli/Microrobots

et al. 2015

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“…Electro-optical polymer based devices are another area of study which has been taking advantage of the MPM as a powerful characterization method [9]. Moreover, recent studies showed the ability of utilizing MPM in three dimensional micro-fabricated devices including sensors, waveguides, photonic structures, and biomedical devices, using various types of light sensitive polymers [10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

All-reflective multiphoton microscope

et al. 2017

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Abstract:We present the design, construction, and characterization of a multiphoton microscope that uses reflective elements for beam shaping and steering. This compact all reflective design removes the adverse effects of dispersion on laser pulse broadening as well as chromatic aberration in the focusing of broadband and multicolored laser sources. The design of this system is discussed in detail, including aberrations analysis via ray-tracing simulation and opto-mechanical design. The resolution of this mirror based all-reflective microscope is characterized using fluorescent microbeads. The performance of the system at multiple wavelengths is investigated along with some potential multiphoton imaging and writing applications. Nelson, and S. Pané, "Hybrid Helical Magnetic Microrobots Obtained by 3D Template-Assisted Electrodeposition," Small 10(7), 1284-1288 (2014). 15. T. Gissibl, S. Thiele, A. Herkommer, and H. Giessen, "Two-photon direct laser writing of ultracompact multilens objectives," Nat. Photonics 10(8), 554-560 (2016). 73-76 (1990). 17. E. E. Hoover and J. A. Squier, "Advances in multiphoton microscopy technology," Nat. Photonics 7(2), 93-101 (2013). 18. K. Kieu, S. Mehravar, R. Gowda, R. A. Norwood, and N. Peyghambarian, "Label-free multi-photon imaging using a compact femtosecond fiber laser mode-locked by carbon nanotube saturable absorber," Biomed. Opt. Express 4(10), 2187-2195 (2013). 19. N. G. Horton and C. Xu, "Dispersion compensation in three-photon fluorescence microscopy at 1,700 nm,"Biomed. Opt. Express 6(4), 1392-1397 (2015). 20. I. D. Tullis, S. M. Ameer-Beg, P. R. Barber, V. Rankov, and B. Vojnovic, "Mapping femtosecond pulse front distortion and group velocity dispersion in multiphoton microscopy," Proc. SPIE 6089, 60890Y (2006). 21. W. Wang, Y. Liu, P. Xi, and Q. Ren, "Origin and effect of high-order dispersion in ultrashort pulse multiphoton microscopy in the 10 fs regime," Appl. Opt. 49(35), 6703-6709 (2010). 22. M. D. Young, J. J. Field, K. E. Sheetz, R. A. Bartels, and J. Squier, "A pragmatic guide to multiphoton microscope design," Adv. Opt. Photonics 7(2), 276-378 (2015). 23. J. Y. Yu, C. S. Liao, Z. Y. Zhuo, C. H. Huang, H. C. Chui, and S. W. Chu, "A diffraction-limited scanning system providing broad spectral range for laser scanning microscopy," Rev.

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“…In this field, some research has been directed to the fabrication method of the microbot prototypes [15,16], to their control and propulsion [17][18][19][20][21][22], and to the study of their communication mechanisms [23][24][25]. It is well known that at a low-Reynolds number regime, non-reciprocal motion is required for a self-propelling device.…”

Section: Introductionmentioning

confidence: 99%

Assessing the Dynamic Performance of Microbots in Complex Fluid Flows

Campo-Deaño

2016

Applied Sciences

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Abstract:The use of microbots in biomedicine is a powerful tool that has been an object of study in the last few years. In the special case of using these microdevices in the human circulatory system to remove clots or to deliver drugs, the complex nature of blood flow must be taken into account for their proper design. The dynamic performance, defined in this context as the quantification of the disturbance of the flow around an object (which is essentially dependent on the microbot morphology and the rheological characteristics of the fluid) should be improved in order to diminish the damage inside the patient body and to increase the efficiency when they swim through the main veins or arteries. In this article, different experimental techniques (micro-Particle Image Velocimetry, flow visualization, pressure drop measurements, etc.) are analyzed to assess their dynamic performance when they swim through the human body immersed in complex fluid flows. This article provides a useful guide for the characterization of the dynamic performance of microbots and also highlights the necessity to consider the viscoelastic character of blood in their design.

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Hybrid Helical Magnetic Microrobots Obtained by 3D Template‐Assisted Electrodeposition

Abstract: Hybrid helical magnetic microrobots are achieved by sequential electrodeposition of a CoNi alloy and PPy inside a photoresist template patterned by 3D laser lithography. A controlled actuation of the microrobots by a rotating magnetic field is demonstrated in a fluidic environment.

Cited by 135 publications

References 15 publications

Biomedical Applications of Untethered Mobile Milli/Microrobots

Biomedical Applications of Untethered Mobile Milli/Microrobots

All-reflective multiphoton microscope

Assessing the Dynamic Performance of Microbots in Complex Fluid Flows

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