Hybrid Gold/Silica/Quantum-Dots supramolecular-nanostructures encapsulated in polymeric micelles as potential theranostic tool for targeted cancer therapy

Volsi, Anna Li; Fiorica, Calogero; D’Amico, Michele; Scialabba, Cinzia; Palumbo, Fabio Salvatore; Giammona, Gaetano; Licciardi, Mariano

doi:10.1016/j.eurpolymj.2018.05.013

Cited by 31 publications

(22 citation statements)

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“…The drug-carrying ability of the copolymer micelles was studied along with the cytotoxicity of the obtained nanostructure, aiming at breast cancer cells employing DOX. The properties of the Au shell Qds incorporated in the micelles as cell imaging agents and a photothermal anticancer treatment tool were explored [79].…”

Section: Polymer Micellesmentioning

confidence: 99%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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Synthetic polymers, biopolymers, and their nanocomposites are being studied, and some of them are already used in different medical areas. Among the synthetic ones that can be mentioned are polyolefins, fluorinated polymers, polyesters, silicones, and others. Biopolymers such as polysaccharides (chitosan, hyaluronic acid, starch, cellulose, alginates) and proteins (silk, fibroin) have also become widely used and investigated for applications in medicine. Besides synthetic polymers and biopolymers, their nanocomposites, which are hybrids formed by a macromolecular matrix and a nanofiller (mineral or organic), have attracted great attention in the last decades in medicine and in other fields due to their outstanding properties. This review covers studies done recently using the polymers, biopolymers, nanocomposites, polymer micelles, nanomicelles, polymer hydrogels, nanogels, polymersomes, and liposomes used in medicine as drugs or drug carriers for cancer therapy and underlines their responses to internal and external stimuli able to make them more active and efficient. They are able to replace conventional cancer drug carriers, with better results. Appl. Sci. 2019, 9, 3899 2 of 24 nanocomposites offer numerous opportunities in diverse applications, including nanocarriers, tissue engineering, antimicrobials, sensors, etc. These new groups of materials have gained significant research interest due to their novel properties, which are gained through the addition of nanofillers. Polymer nanocomposites have significant potential in disease theranostics, and nanotechnology brings great promise in cancer drug carriers [4].Chemotherapy implies the use of drugs and, besides the drugs, carriers. Common products used as carriers include synthetic polymers, biopolymers, and polymer nanocomposites.Some of the most useful drugs for chemotherapy are toxic chemicals able to inhibit the proliferation of cancer cells. The use of chemotherapeutic drugs has been in part hindered by their poor solubility in water, their short biological half-life, their lack of targeting ability, and the development of multidrug resistance [5]. In the last decades, nanoparticles have shown significant promise as an oncology treatment modality. Responsive polymers represent a promising class of nanoparticles that can trigger delivery through the exploitation of a specific stimuli. Response to a stimulus is one of the most basic processes found in living systems. A tutorial review highlighted the recent developments in polymer-based approaches to internally responsive nanoparticles for oncology [6].One important goal of medicine is to develop carriers that can selectively deliver anticancer drugs to tumor cells with no or minimal side effects in healthy cells [7,8].Polymers and their nanocomposites in different forms, such as micelles, hydrogels, polymersomes, and liposomes, have important potential in cancer diagnosis and treatment.Nanocomposites are popular in many areas due to properties such as their unique design capacity, eco-friendly nature, ...

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Section: Polymer Micellesmentioning

confidence: 99%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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“…It was observed that the reported NPs indicated better dispersion in water, prolonged release behavior in vitro and enhanced tumor cellular uptake, showing superior antitumor efficacy and better apoptosis. Volsi et al [166] reported the synthesis of polymeric micelles encapsulating both doxorubicin and gold core-shell quantum dots nanoparticles (Au-SiO 2 /QDs). The formulation was found to have the cytotoxicity of the breast cancer cells.…”

Section: Polymeric Micellesmentioning

confidence: 99%

Progress in Polymeric Nano-Medicines for Theranostic Cancer Treatment

et al. 2020

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Cancer is a life-threatening disease killing millions of people globally. Among various medical treatments, nano-medicines are gaining importance continuously. Many nanocarriers have been developed for treatment, but polymerically-based ones are acquiring importance due to their targeting capabilities, biodegradability, biocompatibility, capacity for drug loading and long blood circulation time. The present article describes progress in polymeric nano-medicines for theranostic cancer treatment, which includes cancer diagnosis and treatment in a single dosage form. The article covers the applications of natural and synthetic polymers in cancer diagnosis and treatment. Efforts were also made to discuss the merits and demerits of such polymers; the status of approved nano-medicines; and future perspectives.

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“…One of the most important approaches for QD surface functionalization is their encapsulation into a layer of amphiphilic diblock or triblock copolymer. Volsi et al [13] functionalized α,β-poly(N-hydroxyethyl)-D,L-aspartamide (PHEA) with lipoic acid (LA), PEG and FA to form an amphiphilic copolymer (PHEA-LA-PEG-FA) that selfassembled into micelles in aqueous medium. Hybrid gold-silica/CdSe-CdS QDs (Au-SiO 2 /QDs) were prepared and co-encapsulated with doxorubicin into the hydrophobic core of PHEA-LA-PEG-FA micelles.…”

Section: Polymer-qd Hybrid Nano-theranosticsmentioning

confidence: 99%

“…Upon irradiation of MCF-7 cells with a laser beam at 810 nm, Au-SiO 2 /QDs micelles demonstrated more powerful cytotoxic effect to the cells compared with free doxorubicin, which could be correlated to the hyperthermic effect of Au-SiO 2 /QDs. A synergistic photothermal/chemotherapeutic killing effect was obtained when cells were irradiated in the presence of both QDs and doxorubicin co-loaded micelles [13].…”

Section: Polymer-qd Hybrid Nano-theranosticsmentioning

confidence: 99%