Mobile e-commerce is e-commerce implemented on mobile devices, such as mobile phones, and mobile Internet networks as we usually understand. With the rapid development of mobile electronic devices and mobile Internet networks, this new type of e-commerce field has gradually emerged. In the context of edge computing, this paper takes mobile e-commerce information system as the research object and aims to study the mobile e-commerce information system based on industry clusters under edge computing. First of all, this paper expounds the theory of industrial clusters and the manifestations of e-commerce industrial clusters, as well as the concept and technical framework of the Internet of Things, and proposes the order relationship analysis method and the fuzzy comprehensive evaluation method, and conducts experiments in the form of questionnaires. The experimental results show that, from the perspective of industrial integration, with a correlation coefficient of 0.687, there is a significant positive correlation between e-commerce information system and supply chain cooperation.