Hybrid fullerene conjugates as vectors for DNA cell-delivery

Uritu, Cristina M.; Varganici, Cristian–Dragos; Ursu, Laura; Coroabă, Adina; Nicolescu, Alina; Dascalu, Andrei; Peptanariu, Dragos; Stan, Daniela; Constantinescu, Cristina Ana; Simion, Viorel; Calin, Manuela; Maier, Stelian Sergiu; Pinteala, Mariana; Barboiu, Mihail

doi:10.1039/c4tb02040e

Cited by 41 publications

(34 citation statements)

References 40 publications

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“…Other areas where carbon nanotubes can be used include various electronic applications [9,45]. Fullerenes and their derivatives can be used in medicine [46], including drug and gene delivery [47] or in cosmetics [48][49][50]. Graphene has numerous applications as well: it can be used in electronics, various biochemical sensors, in solar cells and others summarized in a recently published review by Choi et al [51].…”

Section: Potential Applications Of Carbon-based Nanomaterialsmentioning

confidence: 99%

Carbon nanomaterials: production, impact on plant development, agricultural and environmental applications

Zaytseva

Neumann

2016

Chem. Biol. Technol. Agric.

352

152

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During the relatively short time since the discovery of fullerenes in 1985, carbon nanotubes in 1991, and graphene in 2004, the unique properties of carbon-based nanomaterials have attracted great interest, which has promoted the development of methods for large-scale industrial production. The continuously increasing commercial use of engineered carbon-based nanomaterials includes technical, medical, environmental and agricultural applications. Regardless of the application field, this is also associated with an increasing trend of intentional or unintended release of carbon nanomaterials into the environment, where the effect on living organisms is still difficult to predict. This review describes the different types of carbon-based nanomaterials, major production techniques and important trends for agricultural and environmental applications. The current status of research regarding the impact of carbon nanomaterials on plant growth and development is summarized, also addressing the currently most relevant knowledge gaps.

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Section: Potential Applications Of Carbon-based Nanomaterialsmentioning

confidence: 99%

Carbon nanomaterials: production, impact on plant development, agricultural and environmental applications

Zaytseva

Neumann

2016

Chem. Biol. Technol. Agric.

352

152

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“…This compensated the effect that 57 was less efficient vehicle than C60-PEI. Because the efficiency of 57 transporting pEYFP-C1 plasmid at the N/P ratio above 60 was comparable with that of C60-PEI/pEYFP (N/P ratio = 20) [129]. Other examples showed that C60-PEGs improved effective dosage of 5-FU and PTX.…”

Section: Drug Deliverymentioning

confidence: 88%

Biological applications of hydrophilic C60 derivatives (hC60s)− a structural perspective

Zhu

Sollogoub

Zhang

2016

European Journal of Medicinal Chemistry

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Abstract:Reactive oxygen species (ROS) generation and radical scavenging are dual properties of hydrophilic C60 derivatives (hC60s). hC60s eliminate radicals in dark, while they produce reactive oxygen species (ROS) in the presence of irradiation and oxygen. Compared to the pristine C60 suspension, the aqueous solution of hC60s is easier to handle in vivo. hC60s are diverse and could be placed into two general categories: covalently modified C60 derivatives and pristine C60 solubilized non-covalently by macromolecules. In order to present in detail, the above categories are broken down into 8 parts: C60(OH)n, C60 with carboxylic acid, C60 with quaternary ammonium salts, C60 with peptide, C60 containing sugar, C60 modified covalently or non-covalently solubilized by cyclodextrins (CDs), pristine C60 delivered by liposomes, functionalized C60-polymer and pristine C60 solubilized by polymer. Each hC60 shows the propensity to be ROS producer or radical scavenger. This preference is dependent on hC60s structures. For example, major application of C60(OH)n is radical scavenger, while pristine C60/γ-CD complex usually serves as ROS producer. In addition, the electron acceptability and innate hydrophobic surface confer hC60s with O2 uptake inhibition, HIV inhibition and membrane permeability. In this review, we summarize the preparation methods and biological applications of hC60s according to the structures.

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“…Using conjugates with high water solubility based on fullerene (as a core) and polyethyleneimine (as a shell) [106], transfection efficiencies equivalent to the results reported in literature were obtained [107].…”

Section: Gene Deliverymentioning

confidence: 88%

Polymer engineering for drug/gene delivery: from simple towards complex architectures and hybrid materials

David

Fundueanu²,

Pinteala³

et al. 2014

Pure and Applied Chemistry

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Hybrid fullerene conjugates as vectors for DNA cell-delivery

Abstract: C60-PEI and C60-PEG-PEI as efficient binders of dsDNA, with good transfection up to 25%, high cytocompatibility and cell proliferation up to 200%.

Cited by 41 publications

References 40 publications

Carbon nanomaterials: production, impact on plant development, agricultural and environmental applications

Carbon nanomaterials: production, impact on plant development, agricultural and environmental applications

Biological applications of hydrophilic C60 derivatives (hC60s)− a structural perspective

Polymer engineering for drug/gene delivery: from simple towards complex architectures and hybrid materials

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