Hybrid Dual Mode Sensor for Simultaneous Detection of Two Serum Metabolites

Hu, Chunxiao; Al-Rawhani, Mohammed A.; Cheah, Boon Chong; Velugotla, Srinivas; Cumming, David R. S.

doi:10.1109/jsen.2017.2774359

Cited by 7 publications

(6 citation statements)

References 39 publications

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“…SPR measurements have also been demonstrated on the same platform in related works [28,29]. Multimode multiplexing and simultaneous assays have also been achieved [32,35,36]. Altogether, the chip demonstrated to be suitable for four different sensing techniques to be used independently or simultaneously.…”

Section: Discussionmentioning

confidence: 86%

“…Simultaneous Assay Since the sensors can be independently addressed, different modalities can be used at the same time. In [35], we demonstrated that the Multicorder platform can operate both colorimetric and pH sensing to simultaneously quantify glucose and cholesterol. In [32], we also demonstrate that physical separations fabricated on top of the sensing area enable the use of the Multicorder for simultaneous enzymebased assays of multiple metabolites.…”

Section: Dmentioning

confidence: 99%

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The Multicorder: A Handheld Multimodal Metabolomics-on-CMOS Sensing Platform

Annese

Accarino

et al. 2019

2019 IEEE 8th International Workshop on Advances in Sensors and Interfaces (IWASI)

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The use of CMOS platforms in medical point-of-care applications, by integrating all steps from sample to data output, has the potential to reduce the diagnostic cost and the time from days to seconds. Here we present the 'Multicorder' technology, a handheld versatile multimodal platform for rapid metabolites quantification. The current platform is composed of a cartridge, a reader and a graphic user interface. The sensing core of the cartridge is the CMOS chip which integrates a 16x16 array of multi-sensor elements. Each element is composed of two optical and one chemical sensor. The platform is therefore capable of performing multi-mode measurements: namely colorimetric, chemiluminescence, pH sensing and surface plasmon resonance. In addition to the reader that is employed for addressing, data digitization and transmission, a tablet computer performs data collection, visualization, analysis and storage. In this paper, we demonstrate colorimetric, chemiluminescence and pH sensing on the same platform by on-chip quantification of different metabolites in their physiological range. The platform we have developed has the potential to lead the way to a new generation of commercial devices in the footsteps of the current commercial glucometers for quick multi-metabolite quantification for both acute and chronic medicines.

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Section: Discussionmentioning

confidence: 86%

Section: Dmentioning

confidence: 99%

The Multicorder: A Handheld Multimodal Metabolomics-on-CMOS Sensing Platform

Annese

Accarino

et al. 2019

2019 IEEE 8th International Workshop on Advances in Sensors and Interfaces (IWASI)

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“…The entire sensor platform is a handheld device with cable connection to a computing platform ( Figure 3 ) ( Hu et al, 2018 ; Al-Rawhani et al, 2020 ; Annese et al, 2021 ). It is comprised of several components.…”

Section: Methodsmentioning

confidence: 99%

Factor VIII companion diagnostic for haemophilia

Annese

Giagkoulovits

et al. 2022

Front. Bioeng. Biotechnol.

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Haemophilia is predominantly an inherited disorder that impairs the body’s ability to make blood clots, a process needed to stop bleeding. The condition of this disease is complex to manage, but many patients do so through home therapy and often only see their core multidisciplinary healthcare team annually. There is an increasing need for patients to be able to monitor their condition efficiently at home while staying connected with their healthcare team. As a consequence, a low-cost handheld self-monitoring solution for clotting factor is required. Here we have demonstrated a suitable one-step Factor VIII companion diagnostic sensing approach based on a chromogenic assay for haemophilia A. The results show comparable performance to the gold standard method. Our approach is able to deliver accurate cost-effective results in under 5 min from undiluted human plasma. It has the potential to be able to reduce the human and monetary costs of over- or under-medication for haemophiliacs.

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“…Urate, cholesterol and urea-urease metabolites were used for chemiluminescence, colorimetric and H + measurement modes. Instead of showing reaction rates [49], [50] real time measurement signals were plotted to demonstrate the performance of each sensor. The SPR mode was demonstrated with glycerol.…”

Section: Biological Experimentsmentioning

confidence: 99%

Multimodal Integrated Sensor Platform for Rapid Biomarker Detection

Al-Rawhani

Mitra

Barrett

et al. 2020

IEEE Trans. Biomed. Eng.

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Precision metabolomics and quantification for costeffective, rapid diagnosis of disease are key goals in personalized medicine and point-of-care testing. Presently, patients are subjected to multiple test procedures requiring large laboratory equipment. Microelectronics has already made modern computing and communications possible by integration of complex functions within a single chip. As More than Moore technology increases in importance, integrated circuits for densely patterned sensor chips have grown in significance. Here, we present a versatile single CMOS chip forming a platform to address personalized needs through on-chip multimodal optical and electrochemical detection that will reduce the number of tests that patients must take. The chip integrates interleaved sensing subsystems for quadruplemode colorimetric, chemiluminescent, surface plasmon resonance and hydrogen ion measurements. These subsystems include a photodiode array and a single photon avalanche diode array, with some elements functionalized to introduce a surface plasmon resonance mode. The chip also includes an array of ion sensitive field effect transistors. The sensor arrays are distributed uniformly over an active area on the chip surface in a scalable and modular design. Bio-functionalization of the physical sensors yields a highly selective simultaneous multiple-assay platform in a disposable format. We demonstrate its versatile capabilities through quantified bioassays performed on-chip for glucose, cholesterol, urea and urate, each within their naturally occurring physiological range.

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Hybrid Dual Mode Sensor for Simultaneous Detection of Two Serum Metabolites

Cited by 7 publications

References 39 publications

The Multicorder: A Handheld Multimodal Metabolomics-on-CMOS Sensing Platform

The Multicorder: A Handheld Multimodal Metabolomics-on-CMOS Sensing Platform

Factor VIII companion diagnostic for haemophilia

Multimodal Integrated Sensor Platform for Rapid Biomarker Detection

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