Hybrid Cybernetic Modeling of the Microbial Production of Polyhydroxyalkanoates Using Two Carbon Sources

Duvigneau, Stefanie; Dürr, Robert; Kranert, Lena; Wilisch‐Neumann, Annette; Carius, Lisa; Findeisen, Rolf; Kienle, Achim

doi:10.1016/b978-0-323-88506-5.50305-3

Cited by 3 publications

(1 citation statement)

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“…Some approaches appear promising due to their simplicity and are able to reproduce the concentration curves in a qualitative manner, while they contain only little metabolic information [19][20][21]. Other approaches take the metabolism into account, however, due to their complexity, they can only be used to a limited extent for model-based process control intensification and are difficult to transfer to other PHA producers [22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Advanced Kinetic Modeling of Bio-co-polymer Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Production Using Fructose and Propionate as Carbon Sources

et al. 2021

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Biopolymers are a promising alternative to petroleum-based plastic raw materials. They are bio-based, non-toxic and degradable under environmental conditions. In addition to the homopolymer poly(3-hydroxybutyrate) (PHB), there are a number of co-polymers that have a broad range of applications and are easier to process in comparison to PHB. The most prominent representative from this group of bio-copolymers is poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). In this article, we show a new kinetic model that describes the PHBV production from fructose and propionic acid in Cupriavidus necator (C. necator). The developed model is used to analyze the effects of process parameter variations such as the CO2 amount in the exhaust gas and the feed rate. The presented model is a valuable tool to improve the microbial PHBV production process. Due to the coupling of CO2 online measurements in the exhaust gas to the biomass production, the model has the potential to predict the composition and the current yield of PHBV in the ongoing process.

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