Hybrid Ceramic Polymers: New, Nonbiofouling, and Optically Transparent Materials for Microfluidics

Sikanen, Tiina; Aura, Susanna; Heikkilä, Liisa; Kotiaho, Tapio; Franssila, Sami; Kostiainen, Risto

doi:10.1021/ac1004053

Cited by 29 publications

(27 citation statements)

References 46 publications

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“…Fig. 1) and V=V ∘ ¼ 2.8 from simulations with the channel zeta potential ζ c ¼ −50 mV [64]. Such an agreement is acceptable, considering the assumptions made in the model.…”

supporting

confidence: 52%

Bimetallic Microswimmers Speed Up in Confining Channels

et al. 2016

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Synthetic microswimmers are envisioned to be useful in numerous applications, many of which occur in tightly confined spaces. It is therefore important to understand how confinement influences swimmer dynamics. Here we study the motility of bimetallic microswimmers in linear and curved channels. Our experiments show swimmer velocities increase, up to 5 times, with the degree of confinement, and the relative velocity increase depends weakly on the fuel concentration and ionic strength in solution. Experimental results are reproduced in a numerical model which attributes the swimmer velocity increase to electrostatic and electrohydrodynamic boundary effects. Our work not only helps to elucidate the confinement effect of phoretic swimmers, but also suggests that spatial confinement may be used as an effective control method for them.

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“…Fig. 1) and V=V ∘ ¼ 2.8 from simulations with the channel zeta potential ζ c ¼ −50 mV [64]. Such an agreement is acceptable, considering the assumptions made in the model.…”

supporting

confidence: 52%

Bimetallic Microswimmers Speed Up in Confining Channels

et al. 2016

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“…40 Applications of ORMOCERs include abrasion resistant transparent coatings, 40 barrier layers for food packaging, 40 elements for optical applications, 40 microchip capillary electrophoresis, 15,41 and surface assisted laser desorption ionization mass spectrometry. 42 We have recently studied the hydrophilization and pore formation process of ORMOCOMP by an oxygen plasma process using a different oxygen plasma process (reactive ion etching).…”

Section: H Ormocompmentioning

confidence: 99%

Oxygen and nitrogen plasma hydrophilization and hydrophobic recovery of polymers

Jokinen

Suvanto²,

Franssila³

2012

Biomicrofluidics

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162

118

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Plasma hydrophilization and subsequent hydrophobic recovery are studied for ten different polymers of microfabrication interest: polydimethylsiloxane (PDMS), polymethylmethacrylate, polycarbonate, polyethylene, polypropylene, polystyrene, epoxy polymer SU-8, hybrid polymer ORMOCOMP, polycaprolactone, and polycaprolactone/D,L-lactide (P(CL/DLLA)). All polymers are treated identically with oxygen and nitrogen plasmas, in order to make comparisons between polymers as easy as possible. The primary measured parameter is the contact angle, which was measured on all polymers for more than 100 days in order to determine the kinetics of the hydrophobic recovery for both dry stored and rewashed samples. Clear differences and trends are observed both between different polymers and between different plasma parameters.

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“…Ormocomp® is a hybrid polymer with well‐defined electrical and optical properties. Ormocomp® has been demonstrated to be an extremely biocompatible material and has found usage in analytical,15 drug delivery,16 and dental17 applications as well as in biological systems such as tissue engineering scaffolds18, 19; however, its biocompatibility for human MSC has not been studied before.…”

Section: Introductionmentioning

confidence: 99%

Cell adhesion and osteogenic differentiation on three‐dimensional pillar surfaces

Kaivosoja

Suvanto

Barreto

et al. 2012

J Biomedical Materials Res

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We hypothesized that when compared with conventional two-dimensional (2D) cultures, substrates containing 3D micropillars would allow cells to grow at levels, activating their cytoskeleton to promote osteogenesis. Fibroblasts, osteoblast-like cells, and mesenchymal stem cells (MSCs) were studied. Planar substrates were compared with 200-nm-, 5-μm-, and 20-μm-high pillars of Ormocomp®, Si, diamond-like carbon, or TiO(2). Scanning electron microscopy and staining of actin cytoskeleton showed 7.5-h adhesion to pillar edges and 5-day stretching between adhesion contacts > 100-μm distances of fibroblast and MSC in 3D networks, whereas SaOS-2 cells adhered flatly and individually on horizontal and vertical surfaces. ERK and ROCK immunostaining at 14 and 21 days confirmed activation of the cytoskeleton. In contrast to expectations, success to induce osteogenesis was dominated by the cytocompatibility of the substrate over the 3D structure. This was shown using early alkaline phosphatase, intermediate osteopontin, and late mineralization markers, together with bone nodule formation, which were seen in planar substrates and low-profile TiO(2) pillars, but were poor in the 20-μm landscape. The lack of intercellular contacts seems to halt the osteogenesis-promoting effects of cytoskeletal organization and tension described earlier.

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Hybrid Ceramic Polymers: New, Nonbiofouling, and Optically Transparent Materials for Microfluidics

Cited by 29 publications

References 46 publications

Bimetallic Microswimmers Speed Up in Confining Channels

Bimetallic Microswimmers Speed Up in Confining Channels

Oxygen and nitrogen plasma hydrophilization and hydrophobic recovery of polymers

Cell adhesion and osteogenic differentiation on three‐dimensional pillar surfaces

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