Hybrid carcinoma of the salivary gland: salivary duct adenocarcinoma adenoid cystic carcinoma

Snyder, Matthew L.; Paulino, Augusto F. G.

doi:10.1046/j.1365-2559.1999.00761.x

Cited by 32 publications

(24 citation statements)

References 13 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…While the possibility of developing multiple tumors that coalesce and invade each other and the production of collision tumors that simulate a single entity does exist in major salivary glands, the probability of this phenomenon to occur in the minor salivary glands is remote, and therefore the diagnosis of a hybrid tumor and tumors with biphasic differentiation should be strongly considered when the tumor contains two different tumor entities which are not separated and are located in the same topographical area. Since its original description, less than 30 cases of hybrid tumors of salivary gland origin have been reported to date (1)(2)(3)(4)(5). Most cases have developed within parotid and palatine glands (3), but this entity has been found also in submandibular glands (2,5), maxillary sinus (4) and lacrimal glands (2).…”

Section: Discussionmentioning

confidence: 99%

“…Since its original description, less than 30 cases of hybrid tumors of salivary gland origin have been reported to date (1)(2)(3)(4)(5). Most cases have developed within parotid and palatine glands (3), but this entity has been found also in submandibular glands (2,5), maxillary sinus (4) and lacrimal glands (2). Although there are hybrid tumors with benign components, most of the reported cases are malignant neoplasms (hybrid carcinomas) in which the most frequently identified neoplasm has been ACC (14 out of 25 reported cases).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hybrid salivary gland tumor of the upper lip or just an adenoid cystic carcinoma? Case report

Mosqueda‐Taylor¹,

Cano-Valdez²,

Ruiz-González³

et al. 2009

Med Oral

View full text Add to dashboard Cite

A 65 year-old male patient with a one year-duration tumoral growth located in the upper lip was diagnosed on incisional biopsy as epithelial-myoepithelial carcinoma. After wide surgical excision the histopathological analysis revealed the lesion was composed predominantly (>90%) of adenoid cystic carcinoma. In new sections it was found a very small and isolated area of adenoid cystic carcinoma at the bottom of the incisional biopsy. As surgical margins were free of lesion, no adjuvant treatment was given. The occurrence of a transitory ischaemic attack at 36 months of follow-up led to a neurological and MRI evaluation, which disclosed a well-defined 3.5x3 cm lesion suggestive of metastasis, located on the right temporal area. The lesion was surgically removed and a histopathological diagnosis of neurocysticercosis was rendered. After 40 months of follow-up there is no evidence of recurrence. Conclusion: True hybrid tumors of salivary glands are rare and treatment in each case should be done according to the component with the higher aggressiveness. However, the occurrence of epithelial-myoepithelial carcinoma areas within an adenoid cystic carcinoma seems to be a frequent finding, and because both lesions share a common origin, some authors consider that this may not be a true hybrid neoplasm but a variant of the latter.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hybrid salivary gland tumor of the upper lip or just an adenoid cystic carcinoma? Case report

Mosqueda‐Taylor¹,

Cano-Valdez²,

Ruiz-González³

et al. 2009

Med Oral

View full text Add to dashboard Cite

show abstract

“…nomas (5,(7)(8)(9)(10). It has been postulated that the two tumor components have an identical origin because of the consistent presence of a transitional feature between the two (1,5).…”

mentioning

confidence: 99%

Hybrid Carcinomas of the Salivary Glands: Report of Nine Cases with a Clinicopathologic, Immunohistochemical, and p53 Gene Alteration Analysis

et al. 2002

View full text Add to dashboard Cite

Hybrid carcinomas of the salivary gland are a recently defined and rare tumor entity, consisting of two histologically distinct types of carcinoma within the same topographic area. In this study, we examined nine such cases, which mainly arose in the parotid gland (seven cases), with an additional one each from submandibular and lacrimal glands, and analyzed their clinicopathologic profiles, including immunohistochemical features and p53 gene alterations. The prevalence of hybrid carcinomas was 0.4% among the 1863 cases of parotid gland tumors in our series. The nine patients comprised five men and four women, ranging in age from 40 to 81 years (mean, 62 y). Tumor size ranged from 2 to 10 cm (mean, 4.2 cm). Of the seven patients who were followed up, two were alive with disease and five were alive with no evidence of disease, although the follow-up period was short. Three cases had cervical lymph nodal metastases. The combinations of carcinoma components in our hybrid carcinomas were as follows: epithelial-myoepithelial carcinoma and basal cell adenocarcinoma in two cases, epithelial-myoepithelial carcinoma and squamous cell carcinoma in one case, salivary duct carcinoma and adenoid cystic carcinoma in two cases, myoepithelial carcinoma and salivary duct carcinoma in one, acinic cell carcinoma and salivary duct carcinoma in one, and squamous cell carcinoma and salivary duct carcinoma in two. Although the proportion of each carcinoma component in a tumor mass varied from case to case, the minor component always represented >10% of the area. Differences in cellular composition were studied by immunohistochemistry and electron microscopy. The Ki-67-labeling index apparently differed between the two carcinoma elements in five cases. Diffusely positive p53 immunoreactivity was observed in four cases, restricted to the more aggressive component in each pair. Furthermore, p53 gene alteration analysis of these p53-positive cases revealed that all and three cases demonstrated loss of heterozygosity at p53 microsatellite loci and p53 gene point mutations, respectively, which were detected only in the p53-immunoreactive carcinoma component. Therefore, there is the possibility that such molecular-genetic events take an integral part for inducing the transformation from histologically lower to higher grade tumor during the hybrid carcinoma genesis of the salivary glands.

show abstract

“…Para el correcto diagnóstico de los tipos histológicos se ha utilizado el análisis clinicopatológico y la inmunohistoquímica, existiendo algunos reportes controversiales en cuanto La importancia de diferenciar la histología y el grado de malignidad en el caso de los tumores híbridos radica en el pronóstico y comportamiento distinto que puede tener cada tipo histológico y, en consecuencia, nos permite determinar la mejor terapia. Dado que existe poca información disponible acerca del pronósti-co de dichos tumores, diversos autores concuerdan que el componente con mayor grado de malignidad determinaría el comportamiento bio-lógico de la neoplasia, su pronóstico y manejo 13,15,[18][19][20][21][22] .…”

Section: Discussionunclassified

Tumor híbrido parotídeo

et al. 2012

Rev. Otorrinolaringol. Cir. Cabeza Cuello

View full text Add to dashboard Cite

RESUMENLos tumores de glándulas salivales representan el 3%-10% de las neoplasias de cabeza y cuello. La localización más común es en la glándula parótida, representando el 50%-85% de los casos, siendo 20%-30% de ellos malignos. Los siguientes son indicadores de malignidad: Crecimiento acelerado, masa dolorosa, parálisis facial asociada y linfoadenopatía. La mayoría de las neoplasias de parótida derivan de un único tipo histológico, pero eventualmente puede ocurrir el desarrollo de más de un tipo en la misma glándula. Este trabajo presenta un caso de una neoplasia en parótida con dos tipos histológicos diferentes, con una presentación clínica atípica.El paciente se presentó inicialmente con otalgia y otorrea, al examen destacaba un tumor en el canal auditorio externo. El estudio complementario evidenció una neoplasia de parótida y se realizó resección total de la glándula. La biopsia informó un carcinoma adenoideo-quístico con áreas basaloideas diferenciadas. Se administró radioquimioterapia adyuvante, y el control imagenológico con PET-TC mostró la ausencia de recurrencias o diseminación del tumor.Palabras clave: Cáncer parótida híbrido, tumor híbrido glándula salival. ABSTRACTTumors of the salivary glands represent 33%-10% of head and neck neoplasms. The most common location is the parotid gland, accounting for 50%-85% of the cases, with 20%-30% of them being malignant. The following are known to be indicative of a malignant tumor: fast growing, painless mass, associated facial paralysis and lymphadenopathy. Most parotid neoplasm derive from a single histological type but eventually the development of more than one type on the same gland can occur. This paper presents a case of a parotid neoplasm with two different histological tumors, with uncharacteristic clinical presentation.The patient presented initially with ear pain and otorrhoea, in the clinical examination highlighted an external auditory canal tumor. The complementary study revealed a parotid neoplasm and a total resection of the gland was performed. The biopsy revealed an adenoid-cystic carcinoma with differentiated basaloid areas. Adjuvant radio-chemotherapy was administered, and the imaging control with PET-CT showed no evidence of recurrence or dissemination of the tumor.

show abstract

Hybrid carcinoma of the salivary gland: salivary duct adenocarcinoma adenoid cystic carcinoma

Cited by 32 publications

References 13 publications

Hybrid salivary gland tumor of the upper lip or just an adenoid cystic carcinoma? Case report

Hybrid salivary gland tumor of the upper lip or just an adenoid cystic carcinoma? Case report

Hybrid Carcinomas of the Salivary Glands: Report of Nine Cases with a Clinicopathologic, Immunohistochemical, and p53 Gene Alteration Analysis

Tumor híbrido parotídeo

Contact Info

Product

Resources

About